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Use of opc in preparing medicine for treating and preventing senile dementia

A technology of lotus proanthocyanidins and senile dementia is applied in the field of medicine to achieve the effects of improving SOD activity, reducing MAO-B activity and reducing MAO content

Inactive Publication Date: 2007-04-11
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report about the application of lotus proanthocyanidins in anti-senile dementia drugs at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Improvement effect of lotus proanthocyanidins on ethanol-induced learning and memory impairment mice

[0021] 1 Experimental materials:

[0022] 1.1 Experimental drugs:

[0023]Lotus proanthocyanidin: The raw material of lotus plant is collected from the Lantian planting area of ​​Honghu Lake, and the variety name is "Wuzhi No. 2". Clean the lotus pod (lotus leaf, lotus seed shell, lotus root skin and lotus root joint), add additives, the additives are metaphosphoric acid 0.025-2.5 and sulfite 0.25-2.5, seal and extract with boiling water, and use mesh sand for the extract filter, the filtrate flows through the macroporous resin adsorption column, after washing the unadsorbed impurities with water, rinse the resin adsorption column with 70% ethanol to obtain the ethanol eluate, and concentrate under reduced pressure to remove the ethanol in the eluent. The light brown proanthocyanidin extract powder is obtained by spray drying, and the above extraction proc...

Embodiment 2

[0047] Example 2: Improvement effect of lotus proanthocyanidin and its mixture with huperzine A on scopolamine-induced learning and memory impairment mice

[0048] 1 Experimental materials:

[0049] 1.1 Experimental drugs:

[0050] Lotus proanthocyanidin: The raw material of lotus plant is collected from the Lantian planting area of ​​Honghu Lake, and the variety name is "Wuzhi No. 2". Clean the lotus pod (lotus leaf, lotus seed shell, lotus root skin and lotus root joint), add additives, the additives are metaphosphoric acid 0.025-2.5 and sulfite 0.25-2.5, seal and extract with boiling water, and use mesh sand for the extract filter, the filtrate flows through the macroporous resin adsorption column, after washing the unadsorbed impurities with water, rinse the resin adsorption column with 70% ethanol to obtain the ethanol eluate, and concentrate under reduced pressure to remove the ethanol in the eluent. The light brown proanthocyanidin extract powder is obtained by spray ...

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PUM

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Abstract

The invention discloses a uses of procyanidins from lotus seedpod in preparation medicine for prevention of senile dementia and health care food. Specifically, relating to effects of procyanidins from lotus seedpod for the improvement of young mouse on learning and memory disorder caused by scopolamine and alcohol, also discussing its mechanism of action. Kunming mouse is taken as animal test in said invention, Y maze method adopted, testing the effect of procyanidins from lotus seedpod on learning and memory of the mouse, also testing brain tissue or content or activity of MDA, NO, NOS, SOD, AchE and MAO-B.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of lotus proanthocyanidins in the preparation of medicaments for preventing and treating senile dementia. Background technique [0002] Senile dementia is a neurodegenerative disease of the cerebral cortex in old age, also known as Alzheimer's disease (AD), first described by Alzheimer (1907), clinically manifested as an age-dependent decline in overall cognitive ability and progressive neurological degeneration. Histological examination revealed amyloid Aβ spots, clusters of nerve fibers, and degeneration of axons and dendrites. Biochemically, the main manifestations were the reduction and insufficient synthesis of choline acetyltransferase (ChAT) and acetylcholine (Ach). According to epidemiological surveys, about 15% of the elderly over 65 suffer from dementia in varying degrees, and senile dementia has risen to the fourth or fifth ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/08A61K9/10A61K9/127A61K9/16A61K9/20A61K9/48A61K9/50A61P25/28
Inventor 谢笔钧杨尔宁孙智达龚玉石肖俊松刘亮郭珊珊
Owner HUAZHONG AGRI UNIV
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