Aerosol of brain peptide and preparation method
An aerosol and solvent technology, applied in the field of brain peptide aerosol and its preparation, can solve the problem of few reports, and achieve the effects of consistent bioavailability, high bioavailability, and fast absorption and utilization
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Embodiment 1
[0060] (1) Weigh 1 g of the bacteriostatic agent ethyl p-hydroxybenzoate, add 3000 ml of sterile distilled water, and heat to dissolve;
[0061] (2) Take 0.15 mg of the memory enhancing peptide, add 1000 ml of sterile distilled water, and stir to dissolve;
[0062] (3) Take 140 ml of the solubilizing agent, add the solution obtained in (2), and stir evenly;
[0063] (4) Mix the solution obtained in (1) with the solution obtained in (3), and add sterile distilled water until the solution is 5000ml, and then stir evenly;
[0064] (5) Adjust the pH of the solution obtained in (4) to 4.5-6.5 with 1mol / L HCl and 1mol / L naOH solution;
[0065] (6) Divide the solution obtained in (5) into a sprayer, each with 5ml, and get 1000 bottles.
[0066] Specification: 0.150mg (calculated as anhydrous and acetate) / 5ml / bottle.
Embodiment 2
[0068] (1) Weigh 2 g of the bacteriostatic agent ethyl p-hydroxybenzoate, add 3000 ml of sterile distilled water, and heat to dissolve;
[0069] (2) Take 0.300g of the memory enhancing peptide, add 1000ml of sterile distilled water, stir to dissolve;
[0070](3) Take 250ml of the solubilizing agent glycerin, add to the solution obtained in (2), and stir evenly;
[0071] (4) Mix the solution obtained in (1) with the solution obtained in (3), add sterile distilled water to 5000ml, and then stir evenly;
[0072] (5) Adjust the pH of the solution obtained in (4) to 4.5-6.5 with 1mol / L HCl and 1mol / L naOH solution;
[0073] (6) Divide the solution obtained in (5) into a sprayer, each bottle of 5ml, that is, 1000 bottles.
[0074] Specification: 0.300mg (calculated as anhydrous and acetate) / 5ml / bottle.
Embodiment 3
[0076] (1) Weigh 4.5 g of the bacteriostatic agent ethyl p-hydroxybenzoate, add 3000 ml of sterile distilled water, and heat to dissolve;
[0077] (2) Take 0.15 mg of the memory enhancing peptide, add 1000 ml of sterile distilled water, and stir to dissolve;
[0078] (3) Take 360ml of the solubilizer, add the solution obtained in (2), and stir evenly;
[0079] (4) Mix the solution obtained in (1) with the solution obtained in (3), and add sterile distilled water until the solution is 5000ml, and then stir evenly;
[0080] (5) Adjust the pH of the solution obtained in (4) to 4.5-6.5 with 1mol / L HCl and 1mol / L naOH solution;
[0081] (6) Divide the solution obtained in (5) into a sprayer, each with 5ml, and get 1000 bottles.
[0082] Specification: 0.450mg (calculated as anhydrous and acetate) / 5ml / bottle
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