Preparation method and application of hydrogen-powered micromotor

A technology of power and preparation, applied in the field of preparation of hydrogen-powered micromotors, can solve the problems of slowness and difficulty in obtaining curative effect of hydrogen therapy, and achieve the effect of enhancing exercise ability

Pending Publication Date: 2021-05-07
SOUTHERN MEDICAL UNIVERSITY
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Artificial micro / nanomotors (micro-and nanomotors, MNMs) are a technology capable of converting chemical or external energy into mechanical motion to accomplish complex tasks, but so far, manufacturing micro- and nanomotors with fully biocompatible and biodegradable It is still challenging to precisely deliver nanomotor systems to target tissues, especially for hydrogen therapy, because it is difficult to effectively accumulate hydrogen gas at the lesion site, making it difficult to achieve a good curative effect for hydrogen therapy
Moreover, how to realize the slow release of hydrogen while storing a large amount of hydrogen for the implementation of hydrogen therapy is still a big challenge.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of hydrogen-powered micromotor
  • Preparation method and application of hydrogen-powered micromotor
  • Preparation method and application of hydrogen-powered micromotor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0068] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.

[0069] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.

[0070] Preparation of Hydrogen-Powered Microrobots (HPMs)

[0071] Proceed as follows:

[0072] (1) Pass the Mg balls through a 800-1000-mesh sieve to obtain Mg ball particles with a size of about 10 μm.

[0073] (2) Coat a layer of 2% polyvinylpyrrolidone solution (PVP, molecular weight 40000, dosage is about 120μL), appropriate amount of Mg spherical particles and 1% polylactic acid-glycolic acid copolymer (PLGA, dos...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method and application of a hydrogen-powered micromotor. The hydrogen-powered micromotor comprises a magnesium element core and a polylactic acid-glycollic acid copolymer shell wrapping the magnesium element core, wherein the polylactic acid-glycollic acid copolymer shell is provided with at least one notch, so that the magnesium element core can be communicated with the external environment. The hydrogen-powered micromotor has a Janus structure, can stably release H2 in an aqueous medium, and has a motion characteristic; and by injecting the material in vivo, the infarction area can be effectively reduced, and the hydrogen-powered micromotor has an excellent effect of relieving inflammation caused by acute ischemic stroke.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a method for preparing a hydrogen-powered micromotor and its application. Background technique [0002] Stroke is an acute cerebrovascular disease characterized by high mortality and disability. The incidence of ischemic stroke is rising more rapidly than that of hemorrhagic stroke. In related technologies, thrombolytic therapy combined with neuroprotective measures is mainly used clinically for ischemic stroke. Thrombolytic therapy includes intravenous thrombolysis, arterial thrombolysis, arterial thrombectomy and other endovascular treatment techniques to restore the blood in the ischemic part of the brain. flow. However, after vascular blood reflow, the improvement of cerebral ischemia-hypoxic state will further aggravate tissue damage and inflammatory response. This phenomenon is called cerebral ischemia-reperfusion injury (Cerebral Ischaemia-Reperfusion Injury, CIRI). ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/34A61K33/00A61K33/06A61K9/00A61P29/00A61P39/06A61P9/10
CPCA61K47/34A61K33/00A61K33/06A61K9/0019A61P29/00A61P39/06A61P9/10
Inventor 涂盈锋王双虎刘坤刘叔文
Owner SOUTHERN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap