Applications of morinda officinalis how fructo oligosaccharide extract in preparation of drugs, health products or food for prevention and treatment of Alzheimer's disease

A technology of fructooligosaccharides and extracts, which is applied in the field of application of Morinda officinalis fructooligosaccharides extracts in the preparation of anti-Alzheimer's drugs, health care products or food, and can solve the problem of fructooligosaccharides extracts from Morinda officinalis Wait for the question

Inactive Publication Date: 2017-09-15
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the research on Morinda officinalis fructooligosaccharides at home and abroad mainly focuses on antipsychotic agents and immune adjuvants, but t

Method used

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  • Applications of morinda officinalis how fructo oligosaccharide extract in preparation of drugs, health products or food for prevention and treatment of Alzheimer's disease
  • Applications of morinda officinalis how fructo oligosaccharide extract in preparation of drugs, health products or food for prevention and treatment of Alzheimer's disease
  • Applications of morinda officinalis how fructo oligosaccharide extract in preparation of drugs, health products or food for prevention and treatment of Alzheimer's disease

Examples

Experimental program
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Embodiment 1

[0028] Embodiment 1: Preparation of Morinda officinalis fructooligosaccharide extract

[0029] Specifically include the following steps:

[0030] Remove the impurities of Morinda officinalis fresh medicinal material, crush it properly; add 8 times the amount of distilled water, boil for 2 hours, filter,

[0031] Add 8 times the amount of distilled water to the filter residue, boil for 2 hours, filter, combine the filtrates, concentrate under reduced pressure to obtain a concentrated solution; add ethanol to the concentrated solution, adjust the concentration of ethanol to 90%, refrigerate, stand for 24 hours, and redissolve the precipitate in hot water water, cooled to room temperature, then added ethanol, adjusted the ethanol concentration to 90%, refrigerated, left standing for 24 hours, and precipitated, which was the crude product of Morinda officinalis fructooligosaccharide; redissolve the crude product of Morinda officinalis fructooligosaccharide in hot water, Cool to 5...

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Abstract

The present invention discloses applications of a morinda officinalis how fructo oligosaccharide extract in preparation of drugs, health products or food for prevention and treatment of Alzheimer's disease. According to the present invention, the in vivo animal experiment study results show that the morinda officinalis how fructo oligosaccharide extract can significantly improve the learning memory ability of the A[beta]1-42 and D-galactose-induced senile dementia simulating model rats, and the animal acute toxicity experiment results show that the safe dose range of the morinda officinalis how fructo oligosaccharide extract is wide, such that the morinda officinalis how fructo oligosaccharide extract can be used in the fields of drugs, health products or food for prevention and treatment of Alzheimer's disease.

Description

technical field [0001] The invention relates to a new application of the fructooligosaccharide extract from Morinda officinalis, in particular to the application of the fructooligosaccharide extract from Morinda officinalis in the preparation of anti-Alzheimer's medicine, health products or food. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. The etiology and pathogenesis of senile dementia are still unclear so far, and there may be multiple factors involved, such as aging, genetics, metabolism, history of head trauma, estrogen deficiency, etc. [0003] Studies have found that the human gut has a very large number of neurons, which is comparable to the...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61P25/28A23L33/105A23L33/125
CPCA23V2002/00A61K31/702A61K36/746A23L33/105A23L33/125A23V2200/30A23V2200/322A23V2250/21A23V2250/50
Inventor 陈地灵杨俭帅欧唐晓萃谢意珍吴清平
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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