Nutritional composition suitable for infants fed by elderly lying-in women

A nutritional composition, technology for infants and young children, applied in the field of nutritional composition

Active Publication Date: 2021-05-28
BIOSTIME GUANGZHOU HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, very few products have been developed for infants and young children fed by older mothers

Method used

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  • Nutritional composition suitable for infants fed by elderly lying-in women
  • Nutritional composition suitable for infants fed by elderly lying-in women
  • Nutritional composition suitable for infants fed by elderly lying-in women

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Investigating the types and contents of oligosaccharides in the breast milk of elderly mothers, and the distribution of intestinal flora of infants fed by elderly mothers

[0046] 1. Research objects: 60 infant volunteers were collected from the Maternal and Children's Hospital.

[0047] The mothers of the infants participating in the experiment will sign an informed agreement and guarantee exclusive breastfeeding during the experiment.

[0048] 2. Inclusion criteria:

[0049] 1) Healthy, full-term infants (gestational age ≥ 37 weeks), vaginal delivery;

[0050] 2) Medically certified healthy infants: asymptomatic and disease-free;

[0051] 3) The age is 0-30 days.

[0052] 3. Experimental method and experimental results:

[0053] By collecting mother's breast milk samples and infant feces at the first month T1 (30d±2d), the second month T2 (60d±2d), and the third month T3 (90d±2d) of the baby's age.

[0054] The content of 24 kinds of oligosaccharides i...

Embodiment 2

[0069] Example 2: Investigating the effect of the nutritional composition of the present invention on the intestinal microecology of infants and young children fed by advanced puerpera through in vitro fermentation test

[0070] In vitro fermentation experiment: The operating unit of the system consists of a batch fermenter and a fecal gas detector. The fermentor contains a carbon-free basal medium (YCFA). The fermentation basal medium without carbon source was added to the medium separately. Basal medium without carbohydrates (YCFA) was used as a control. Lactose, YCFA, oligosaccharide nutritional composition or oligosaccharide+osteopontin nutritional composition were used as the sole carbon source to ferment feces of infants and young children fed by elderly mothers. Those fermented with YCFA were used as the blank group, and those fermented with lactose were used as the lactose control group. Sugar, lactoyl-N-fucopentaose III, lactoyl-N-difucohexaose II, and 2-fucosyllac...

Embodiment 3

[0075] Embodiment 3: Investigating the influence of the nutritional composition of the present invention on the learning and memory ability of the offspring of advanced female rats

[0076]Clean grade Wistar rats were used. The senior female mice (12 months old) and the young female mice (3 months old) were caged separately with randomly selected 3-month-old male mice. After the female mice became pregnant, the male mice were separated from the female mice. After the female rats gave birth, the pups born to the old females were recorded as the senior group, and the pups born to the young females were recorded as the young group. After the pups were breastfed by the mother for one week, 90 pups were randomly selected from the old female mice and divided into the old group, the old + oligosaccharide group, the old + oligosaccharide + osteopontin group, 30 in each group, randomly selected 30 young female rats gave birth to offspring as the young reproductive group. On days 7-2...

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Abstract

The invention provides a nutritional composition for improving intestinal micro-ecology and learning and memory ability of infants fed by elderly lying-in women and application of the nutritional composition in preparation of infant formula milk powder or probiotic products. The utritional composition comprises, in weight percent, from 20% to 35% of sialylated oligosaccharides, from 50% to 60% of fucosylated neutral oligosaccharides, from 5% to 30% of non-fucosylated neutral oligosaccharides, and / or from 0.5% to 5% of osteopontin (OPN); the sialylated oligosaccharide comprises one or two of sialylated-lactose-N-tetrasaccharide c (LSTc) or sialylated-lactose-N-tetrasaccharide b (LSTb), the fucosylated neutral oligosaccharide comprises one or more of 2-fucosyllactose (2-FL), lactyl-N-fucopentasaccharide III (LNFP III), or lactyl-N-difucohexaose II (LNDFH II); and the non-fucosylated neutral oligosaccharide comprises a lactyl-N-neotetraose (LNnT).

Description

technical field [0001] The present invention relates to a nutritional composition. Specifically, it relates to a nutritional composition for improving intestinal microecology and learning and memory ability of infants fed by advanced maternal age. Background technique [0002] With the development of society, people's concept of marriage and childbearing has also changed, and the age of women's childbearing is showing a trend of being pushed back. In addition, due to the liberalization of the domestic two-child policy, the number of elderly pregnant women continues to increase. As women age, their ovarian function declines and the quality of their follicles decreases, leading to reduced fertility and the risk of birth defects. Epidemiological studies have found that pregnancy complications of older women are higher, and the incidence of fetal chromosomal abnormalities is higher. In addition, studies have shown that advanced pregnancy age is closely related to the early ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/20A23L33/21
CPCA23C9/203A23L33/21A23V2002/00A23V2200/3202A23V2200/322A23V2250/284
Inventor 郑雨星刘斐童张斌陈桔淳李红叶王园园乔纳森·莱恩
Owner BIOSTIME GUANGZHOU HEALTH PROD
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