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Combination of medication of containing general saponin of notoginseng and icariin as well as usage

A technology of Panax notoginseng saponins and icariin, which is applied to the composition of Panax notoginseng saponins and icariin to prepare drugs for the treatment of senile dementia, which can solve the problems of lack of adverse reactions and achieve significant anti-aging Oxidative effect, significant estrogen-like effect, effect of expanding drug use

Inactive Publication Date: 2005-06-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the change of my country's social structure, the aging rate of the total population is becoming more and more prominent, and the incidence of senile dementia is gradually increasing. However, there is a clear lack of drugs that can achieve affirmative curative effect, mild adverse reactions, convenient medication, and moderate course of treatment.

Method used

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  • Combination of medication of containing general saponin of notoginseng and icariin as well as usage
  • Combination of medication of containing general saponin of notoginseng and icariin as well as usage
  • Combination of medication of containing general saponin of notoginseng and icariin as well as usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 The preparation method of Panax notoginseng saponins and icariin of the present invention

[0021] (1) Weigh Panax notoginseng powder (20-40 mesh), add 10 times the amount of 70% ethanol to reflux and extract 3 times, each time for 2 hours, filter, combine the filtrates, and concentrate under reduced pressure to a certain volume (0.33g crude drug / ml) , that is, the column solution. Pipette the solution onto the macroporous resin, elute with 7 times the amount of 75% ethanol, and collect the eluate in sections. The eluent was evaporated to dryness in a water bath, concentrated under reduced pressure, dried in vacuo, weighed the total solids and determined the content of total saponins of Panax notoginseng. The total saponin content of this batch of Panax notoginseng > 80%.

[0022] (2) Weighing the dry raw material of Epimedium (ground part crushed material, including stems and leaves) and extracting with ethanol for 3 times (1 hour / time), concentrating and d...

Embodiment 2

[0024] Embodiment 2 The maximum tolerated dose experiment of the composition of the present invention

[0025] (1) Materials and methods:

[0026] The extracts of Panax notoginseng saponins and icariin were obtained by referring to the method in Example 1, and prepared into a suspension with 0.5% sodium carboxymethylcellulose. The drug concentration is equivalent to the content / ml in 10g of crude drug, and before use, it is mixed according to the weight ratio of Panax notoginseng saponins: icariin 0.01:0.99 to form composition A and Panax notoginseng saponins: icariin weight ratio 0.5 : 0.5 and mixed to form composition B.

[0027] Use the maximum concentration (equivalent to 10g of crude drug / ml) and the maximum administration volume of 0.4ml / 10g / time gavage administration, give the mouse composition and the single extract of the two medicinal materials twice a day, with an interval of 5 to 6 hours , observe the body weight and various symptoms of the mice on the day of adm...

Embodiment 3

[0032] Embodiment 3 The maximum tolerated dose experiment 2 of the composition of the present invention

[0033] (1) Materials and methods Refer to Example 2. The test drugs are compositions A to D of Panax notoginseng saponins and icariin in weight ratios of 0.1:0.9, 0.15:0.85, 0.2:0.8, and 0.4:0.6.

[0034] (2) Results:

[0035] The mice had loose stools on the day and the next day of intragastric administration, and dilated auricular vessels on the day of administration, but there was no significant difference among the compositions A to D. No death occurred in all the administration groups, and no apparent adverse symptoms were observed in the subsequent two weeks.

[0036] (3) Conclusion:

[0037] Compositions A to D mice were intragastrically administered with 800 g of the corresponding content / kg of the crude drug, except for loose stools and auricular vasodilation on the day of administration, no death or other obvious toxic reactions occurred.

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Abstract

A liquid or solid medicine for treating sanile dementia is prepared from arasaponin, icaniiin and precipient proportionally. Its advantage is higher curative effect.

Description

technical field [0001] The invention belongs to a natural medicine composition, in particular to a composition of Panax notoginseng saponins and icariin and its application in preparing medicines for treating senile dementia. Background technique [0002] With the change of my country's social structure, the aging rate of the total population is becoming more and more prominent, and the incidence of senile dementia is gradually increasing. However, there is a clear lack of drugs that can achieve affirmative curative effect, mild adverse reactions, convenient medication, and moderate course of treatment. After China's accession to the WTO, there are fewer such new drugs with my country's independent intellectual property rights, and it is urgent to develop new high-tech drugs for the treatment of senile dementia with my country's independent intellectual property rights, positive curative effect, and mild adverse reactions. [0003] Traditional Chinese medicine for senile dem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/7048A61P25/28
Inventor 楼宜嘉王志强肖幸丰吴洪海刘健
Owner ZHEJIANG UNIV
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