Application of Hericium erinaceus extract in preparation of medicines, health products or foods for preventing and treating Alzheimer's disease

A technology of Hericium erinaceus extract and disease medicine, which is applied to the functions, applications, and food ingredients of food ingredients. damage effect

Inactive Publication Date: 2018-05-11
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on Hericium erinaceus at home and abroad mainly focuses on the extraction of Hericium erinaceus polysaccharides and the determination of chemical components, but there are still few studies on the application of Hericium erinaceus extracts in the prevention and treatment of Alzheimer's disease.

Method used

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  • Application of Hericium erinaceus extract in preparation of medicines, health products or foods for preventing and treating Alzheimer's disease
  • Application of Hericium erinaceus extract in preparation of medicines, health products or foods for preventing and treating Alzheimer's disease
  • Application of Hericium erinaceus extract in preparation of medicines, health products or foods for preventing and treating Alzheimer's disease

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of Hericium erinaceus extract

[0030] Specifically include the following steps:

[0031] (1) Dry the fruiting bodies of Hericium erinaceus at 65°C and crush them to 50 mesh;

[0032] (2) At room temperature, take Hericium erinaceus sporocarp powder and add it to a container filled with pre-treated macroporous resin.

[0033] In the glass chromatography column, make the aspect ratio between 1:5;

[0034] (3) Add 5 times the amount of ethanol with a mass concentration of 80%, soak for 2 h, and then connect at a flow rate of 1.0 BV / h

[0035] Continue the elution, collect the ethanol eluate, concentrate under reduced pressure at 60°C to a thick paste with a relative density of 1.2, transfer it to a vacuum drying oven, and dry under reduced pressure at 70°C to obtain Hericium erinaceus extract.

[0036] The combined chemical identification, HPLC, LC-MS and other technical detection results show that it mainly contains Erinacine A, B, C, D, ...

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Abstract

The invention discloses an application of Hericium erinaceus extract in the preparation of medicines, health products or foods for preventing and treating the Alzheimer's disease. In vitro cell experiment researches in the invention find that the Hericium erinaceus extract can significantly enhance the proliferation of PC12 cells and inhibit injuries of Abeta25-35 to the PC12 cells; in vivo animalexperiment researches find that the Hericium erinaceus extract can significantly improve the learning and memory abilities of Abeta25-35 and D-galactose induced senile dementia model rats; and acutetoxicity experiments of cells and animals confirm that the Hericium erinaceus extract has a broad safe dose range, and can be used in the fields of the medicines, health products or foods for preventing and treating the Alzheimer's disease.

Description

technical field [0001] The invention relates to a new application of the Hericium erinaceus extract, in particular to the application of the Hericium erinaceus extract in preparing medicines, health products or food for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. The etiology and pathogenesis of senile dementia are still unclear so far, and there may be multiple factors involved, such as aging, genetics, metabolism, history of head trauma, estrogen deficiency, etc. [0003] Neuron damage is one of the pathogenesis factors of Alzheimer's disease. Modern studies have found that the mechanisms of neuronal ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P25/28A23L33/10A23L31/00
CPCA23V2002/00A61K36/07A61K2236/333A61K2236/51A23V2200/322A23V2250/208
Inventor 陈地灵杨俭帅欧谢意珍吴清平
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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