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Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof

A traditional Chinese medicine preparation, a technology for senile dementia, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc.

Inactive Publication Date: 2008-09-24
GUIYANG MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, among the anti-senile dementia drugs widely used in clinical practice at home and abroad, there are indeed a group of chemical drugs with definite efficacy and relatively safe use. However, like most chemical drugs, nervous system chemical drugs used in clinical practice are also increasingly showing side effect

Method used

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  • Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof
  • Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof
  • Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0363] Example 1: 60g of ginseng, 120g of Radix Astragali Radix, 90g of Epimedium, 90g of Corydalis Corydalis, 120g of Gastrodia elata, 90g of Angelica sinensis, 120g of Polygonum multiflorum, 120g of sealwort and 120g of Shichangpu

[0364] Preparation method: (1) Alcohol extraction: take ginseng, Gastrodia elata, Sun-roasted Astragalus root, Epimedium, and Corydalis Corydalis and extract them twice with 85% ethanol under reflux, each time for 2 hours, add 16 times the amount of ethanol for the first time, and add 14 times the amount of ethanol, filtered to obtain the ethanol extract, and the ethanol was recovered under reduced pressure, and the medicinal solution was set aside;

[0365] (2) Boil in water: take angelica, Radix Polygoni Multiflori, Rhizoma Polygonatum, and Shichangpu and boil them in water for 3 times, each time for 2 hours, add 14 times the amount of water for the first time, and add 12 times the amount for the second and third times water, filtered, and the ...

Embodiment 2

[0369] Example 2: 50g of ginseng, 100g of Radix Astragali, 100g of Epimedium, 100g of Corydalis Corydalis, 140g of Tianma, 80g of Angelica, 100g of Radix Polygoni Multiflori, 100g of Polygonatum and 140g of Shichangpu

[0370] (1) Alcohol extraction: take ginseng, Gastrodia elata, sun-burned astragalus, epimedium, and Corydalis five-flavored medicinal materials and use 20 times the amount of 85% ethanol to reflux extract once, extract for 3 hours, filter to obtain alcohol extract, and recover ethanol under reduced pressure. Liquid standby;

[0371] (2) Boil in water: Take the four medicinal materials of angelica, Radix Polygoni Multiflori, Polygonatum, and Shichangpu, decoct 3 times with 10 times the amount of water, 1 hour each time, filter, and concentrate the filtrate under reduced pressure for later use;

[0372] (3) Formulation of the preparation: combine the alcohol-extracted medicinal liquid and the boiled medicinal liquid, concentrate to a thick paste, and vacuum-dry a...

Embodiment 3

[0374] Example 3: 70g of ginseng, 140g of Radix Astragalus, 80g of Epimedium, 80g of Corydalis Corydalis, 100g of Tianma, 100g of Angelica, 140g of Polygonum multiflorum, 140g of Polygonatum and 1000g of Shichangpu

[0375] (1) Alcohol extraction: Take ginseng, Gastrodia elata, sun-roasted astragalus, epimedium, and Corydalis five-flavored medicinal materials and extract 3 times with 10 times the amount of 85% ethanol, 1 hour each time, filter to obtain alcohol extract, and recover ethanol under reduced pressure. reserve medicine;

[0376] (2) Boil in water: take the four medicinal materials of Angelica sinensis, Radix Polygoni Multiflori, Polygonatum, and Shichangpu, decoct once with 16 times the amount of water, decoct for 3 hours, filter, and concentrate the filtrate under reduced pressure for later use;

[0377] (3) Formulation of the preparation: combine the alcohol-extracted medicinal liquid and the boiled medicinal liquid, concentrate to a thick paste, and vacuum-dry at...

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Abstract

The invention discloses a traditional Chinese medicine formulation for curing senile dementia and a preparation method thereof. The traditional Chinese medicine formulation is made of ginseng, milk veteh, epimedium, fumitory, rhizoma gastrodiae, angelica, radid polygoni multflori preparata, sealwort and grassleaf sweelflag rhizome which are performed by an ethanol extracting technology and a poach technology. The traditional Chinese medicine formulation is ground by the theory of traditional Chinese medicine and adopts a scientific theory and an advanced technology to develop the traditional Chinese medicine formulation with good curative effect and fewer side effects and being used for curing the senile dementia. The experimental research shows that the traditional Chinese medicine formulation can improve the learning memory ability of an AD rat model. Meanwhile, the traditional Chinese medicine formulation can improve the antifatigue and anti-stress ability of an organism and has good curative effect on the kidney empty. In addition, the invention also provides an optimized preparation method suitable for the industrial production.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating senile dementia and a preparation method thereof. Background technique [0002] With the aging of the global population, the incidence of Alzheimer's disease (AD) is increasing year by year. Due to the lack of effective treatment, AD has become the fourth fatal disease that endangers human health after heart, cerebrovascular diseases and tumors. According to statistics, the total number of elderly population over 60 years old in my country accounts for about 10% of the total population, and about 5% are AD patients. Therefore, finding effective drugs to prevent and treat AD has become an urgent problem in life sciences. [0003] At present, among the anti-senile dementia drugs widely used in clinical practice at home and abroad, there are indeed a group of chemical drugs with definite efficacy and rela...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P25/28
Inventor 郝小燕官志忠肖海涛罗俊齐晓岚
Owner GUIYANG MEDICAL UNIVERSITY
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