Application of hederagenin in preparation of medicine for resisting senile dementia

An ivy saponin, senile technology, applied in the directions of drug combination, antidote, pharmaceutical formulation, etc., can solve the problems of lack of drugs and treatment methods, achieve the protective effect of cholinergic system damage, resist brain nerve damage, increase The effect of SOD vitality

Inactive Publication Date: 2012-10-03
杨中林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is still a lack of ideal drugs and treatments for diseases such as senile dementia and cranial nerve injury

Method used

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  • Application of hederagenin in preparation of medicine for resisting senile dementia
  • Application of hederagenin in preparation of medicine for resisting senile dementia
  • Application of hederagenin in preparation of medicine for resisting senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Effect of helexin on Aβ 25-35 Induced repair effect of PC-12 cell injury model

[0014] The purpose of this experiment is to explore the anti-AD activity of hedera sapogenin in vitro.

[0015] 1. Materials and methods:

[0016] Lotion: 10g K 2 Cr 2 o 7 , 16ml H 2 O, 200ml concentrated H 2 SO 4 mixed preparation;

[0017] D-Hank's balanced salt solution: NaCl 4.00g, KCl 0.20g, NaCl 2 HPO 4 12H 2 O 0.067g, KH 2 PO 4 0.03g, NaHCO 3 0.175g, phenol red 0.01g, triple distilled water 500mL, adjust the pH to 7.0-7.4;

[0018] PBS balanced salt solution: NaCl 8.00g, KCl 0.20g, NaCl 2 HPO 4 12H 2 O 3.49g, KH 2 PO 4 0.20g, triple distilled water 1000mL, adjust the pH to 7.2~7.4;

[0019] RPMI 1640 medium: RPMI Medium 1640 dry powder medium (GIBCO Invitrogen) 10.4g, NaHCO 3 2.0g, 0.06g of penicillin (commercially available in units of 4 million U), 0.1006g of streptomycin (commercially available in units of 1 million U), prepared in 900mL of three...

Embodiment 2

[0045] Example 2 In vivo pharmacodynamics of hedera saponin against AD in vivo model of acute AD induced by scopolamine hydrobromide in mice with dementia

[0046] 1. Reagents and kits:

[0047] Hedera saponin (purity is 94.85%, the preparation method is the same as in Example 1); Scopolamine hydrobromide (purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd.);

[0048] Galantamine hydrobromide (Shaanxi Kangsheng Biotechnology Co., Ltd.);

[0049] Ginkgo biloba extract (Xuzhou Hengkai Ginkgo Products Co., Ltd.);

[0050] Coomassie Brilliant Blue Protein Assay Kit (Nanjing Jiancheng Bioengineering Institute);

[0051] Acetylcholinesterase Assay Kit (Nanjing Jiancheng Bioengineering Institute);

[0052] Superoxide dismutase test kit (Nanjing Jiancheng Bioengineering Institute);

[0053] Mouse β-amyloid 1-40 enzyme-linked immunoassay kit (Shanghai Jianglai).

[0054] 2. Animals

[0055] ICR mice, half male and half female, weighing 18-22g (provided by Qinglong M...

Embodiment 3

[0143] Example 3 Take the hedera saponin prepared according to the method of Example 1, add common excipients for capsules, and prepare capsules according to a conventional preparation process.

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Abstract

The invention discloses the application of hederagenin or the medical salt thereof in the preparation of medicine for resisting senile dementia, cranial nerve damage and aging. According to the invention, the hederagenin or the medical salt thereof is used for treating the diseases, the curative effect is excellent, the side effect is small, the security is high, and a novel selection is provided for treating senile cerebral diseases.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of helexin or a pharmaceutically acceptable salt thereof as an active ingredient in the preparation of anti-senile dementia, anti-cranial nerve damage and anti-aging medicines. Background technique [0002] Senile dementia, also known as Alzheimer's disease, is a primary degenerative brain degenerative disease of unknown etiology. Most of the onsets are in old age, the onset is insidious, the course of the disease is slow and irreversible, and the main clinical manifestation is intellectual impairment. The main pathological changes were diffuse atrophy of the cortex, widening of the sulci, enlarged ventricles, a large number of neurons, senile plaques, neurofibrillary knots and other lesions, and the content of choline acetylase and acetylcholine was significantly reduced. The onset before the age of 65 is formerly known as presenile dementia, or Al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P25/28A61P25/00A61P39/06
Inventor 杨中林
Owner 杨中林
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