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Medicament for preventing and treating senile dementia and preparation method thereof

A kind of senile and drug-based technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problem of lack of effective drugs, and achieve the effect of scientific formula, simple preparation process and low preparation cost

Inactive Publication Date: 2013-06-12
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the clinical use of "deferoxamine" can excrete aluminum, relieve the symptoms of Alzheimer's disease and slow down the progress of Alzheimer's disease, "deferoxamine" cannot pass through the blood-brain barrier, which limits its clinical application
In addition, "deferoxamine" is a natural biological auxin, which is difficult to synthesize chemically, expensive, and is not absorbed through the digestive tract, so it is invalid when taken orally
[0004] At present, there is still a lack of effective drugs for the treatment of Alzheimer's disease, especially in the middle and late stages

Method used

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  • Medicament for preventing and treating senile dementia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Preparation of granules: Take 122 grams of seabuckthorn, 98 grams of Yizhi kernel, 93 grams of lotus seeds, 73 grams of Smilax tuckahoe, 70 grams of malt, and 52 grams of calcined oysters, add water to decoct 3 times, each time for 1 hour, and add 8 times each time Measure the water, combine the water decoction, centrifuge at 1500rpm, concentrate the centrifuge under reduced pressure into an extract with a relative density of 1.30-1.37 (50°C), and microwave dry; the dry extract is crushed into a 100-mesh fine powder, according to extract powder: malt Dextrin: Micropowder silica gel: Aspartame=10:5:1:0.04 Mix evenly, use ethanol with a concentration of 50-100% to make a soft material, granulate, dry, and granulate to obtain granules. Take after mixing, 5-30 grams each time, 2-5 times a day.

Embodiment 2

[0072] Preparation of capsules: Take 52 grams of seabuckthorn, 49 grams of Yizhi kernel, 45 grams of lotus seeds, 41 grams of Smilax smilax, 37 grams of malt, and 32 grams of calcined oysters, add 5 times the amount of water to decoct 5 times, each time for 5 hours, combine Decoction in water, dried under reduced pressure, crushed dry extract into 100-mesh fine powder, mixed evenly according to extract powder: microcrystalline cellulose: micropowder silica gel = 12:5:2, dry granulation, granulation, filling, to obtain capsules. Take orally, 2 to 9 capsules at a time, 2 to 5 times a day.

Embodiment 3

[0074] Preparation of tablets: Take 9 grams of seabuckthorn, 8 grams of Yizhi kernels, 7 grams of lotus seeds, 6 grams of Smilax smilax, 5 grams of malt, and 4 grams of calcined oysters, add 10 times the amount of water to decoct for 1 hour, centrifuge at 1500 rpm, and the centrifugate will reduce Press and concentrate into extract, dry under reduced pressure, crush dry extract into 100 mesh fine powder, mix evenly according to extract powder:starch:magnesium stearate=15:7:1, granulate by dry pressing method, granulate, tablet , Coat the plain tablet with film coating auxiliary materials to obtain the tablet. Take orally, 2-9 tablets at a time, 2-5 times a day.

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Abstract

The invention discloses a medicament for preventing and treating senile dementia. The medicament comprises the following components by weight: 5.2-122 g of sea-buckthorn, 4.6-98 g of fructusalpiniaeoxyphyllae, 3.9-93 g of lotus seed, 3.3-73 g of glabrous greenbrier rhizome, 2.8-70 g of malt and 2.2-52 g of calcined oyster shell, wherein the components are extracted, dried and crushed to prepare extract powder; and the extract powder is prepared into different preparations through different methods. The medicament has the advantages of scientific formula and simple process; and a prepared product has a function of eliminating aluminum poison in the body and is suitable for preventing and treating the senile dementia caused by the aluminum poison.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for preventing and treating senile dementia and a preparation method thereof. Background technique [0002] At present, there are many theories about the etiological mechanism of senile dementia. Among them, the accumulation of aluminum in the brain tissue can cause the aging of neurons and cause senile dementia, which is one of them. Aluminum is the most abundant metal in nature, but it is not an essential trace element for the human body. The content of aluminum in normal human brain tissue is very low. The upper limit of aluminum content in normal human brain is only 4 μg / g, while the aluminum content in brain tissue of Alzheimer’s patients is significantly higher than that of normal people, up to 107 μg / g. People have extensive contact with aluminum products, and aluminum can enter the human body through the food chain and medicine. In gener...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P25/28A61K35/56A61K35/618
Inventor 景明
Owner GANSU UNIV OF CHINESE MEDICINE
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