Lactobacillus rhamnosus capable of maintaining bone health and improving local inflammation of joints as well as metagen and application of lactobacillus rhamnosus

The metabiotic product of Lactobacillus rhamnosus NKU ML1-2 enhances the antioxidant capacity of cartilage and osteoblasts, solving the side effects and stability problems of existing osteoarthritis treatments, and achieving safe and effective relief of joint inflammation and maintenance of bone health.

CN121406540AActive Publication Date: 2026-01-27TIANTIANNENG HEALTH IND GRP CO LTD +1
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Patent Information

Application Number
CN202511982720.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-26
Publication Date
2026-01-27
Estimated Expiration
2045-12-26

AI Technical Summary

Technical Problem

While existing treatments for osteoarthritis can relieve symptoms, they do not address the root cause and have side effects. Furthermore, the storage stability and gastrointestinal sensitivity issues of probiotics make it difficult to safely and effectively improve local joint inflammation and maintain bone health.

Method used

The metabiotic product of Lactobacillus rhamnosus NKU ML1-2 is prepared into powder, granules, capsules or oral liquid through fermentation culture. It enhances the antioxidant capacity of cartilage and osteoblasts, promotes the synthesis of anti-inflammatory factors and cartilage matrix, and reduces local oxidative stress and inflammatory response in joints.

Benefits of technology

It enhances the antioxidant capacity of cartilage and osteoblasts, promotes the synthesis of cartilage matrix, safely and effectively inhibits joint inflammation, delays cartilage destruction, and provides a safe and stable probiotic postbiotic product for the prevention and treatment of osteoarthritis.

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Abstract

The invention belongs to the technical field of microbial fermentation, and particularly relates to lactobacillus rhamnosus capable of maintaining bone health and improving local joint inflammation and a metagen and application of the lactobacillus rhamnosus. According to the invention, the probiotic NKU ML1-2 is subjected to fermentation culture, such that a post-generation product is prepared. Results of embodiments prove that the metagen product can enhance the oxidation resistance of cartilage and osteoblasts and promote the synthesis of anti-inflammatory factors and cartilage matrixes (type II collagen and proteoglycan), and has the potential of relieving oxidative stress and inflammatory response of local joints, relieving joint inflammation and delaying cartilage destruction. The prepared metagen product is high in safety and good in stability, and can be applied to preparation of medicines for preventing and / or treating osteoarthritis; the metagen product can also be used for promoting bone health, enhancing the antioxidant capacity of osteoblasts and / or chondrocytes, promoting osteoblast activity and / or promoting calcium absorption and fixation, and a new solution is provided for joint health management.
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