Application of isodan leaf emodin in preparation of Icam1 inhibitor

By preparing isopanthene, an Icam1 inhibitor, the problem of sepsis-induced liver injury was solved. By inhibiting the expression of the transmembrane protein intercellular adhesion molecule-1, pro-inflammatory factors were reduced and anti-inflammatory factors were increased, significantly improving the liver injury condition.

CN121534024APending Publication Date: 2026-02-17HENAN ACADEMY OF MEDICAL SCIENCES
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Patent Information

Application Number
CN202511907565.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-17
Publication Date
2026-02-17

AI Technical Summary

Technical Problem

Current technologies have not been able to effectively address liver damage caused by sepsis, especially the high incidence of liver damage in patients with severe sepsis, and the risk is even higher for patients with chronic liver disease.

Method used

Using isopanol as the active ingredient, an Icam1 inhibitor was prepared to reduce the secretion of pro-inflammatory factors in the liver and increase the secretion of anti-inflammatory factors, thereby treating liver damage caused by sepsis.

Benefits of technology

Emodin significantly reduced the levels of pro-inflammatory factors TNF-α, IL-1β and IL-6 in liver tissue, increased the level of anti-inflammatory factor IL-10, reduced inflammatory cell infiltration in liver tissue, protected the structural integrity of liver tissue, reduced liver function indicators, and effectively alleviated sepsis-related liver damage.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of isodan leaf emodin in preparation of an Icam1 inhibitor, related experiments of establishment of a sepsis liver injury model induced by cecum ligation puncture (CLP) show that by applying the isodan leaf emodin, the Icam1 inhibitor can be used for preparing Icam1. According to the present invention, the level of liver tissue proinflammatory factors TNF-alpha, IL-1beta and IL-6 in the liver injury caused by sepsis is reduced, the level of the anti-inflammatory factor IL-10 is increased, and the HE dyeing of the liver tissue proves that the emodin can alleviate the CLP induced inflammatory cell infiltration in the liver tissue, can protect the structural integrity of the liver tissue, and can provide the anti-inflammatory effect on the liver tissue, such that the liver injury caused by sepsis can be inhibited, and the liver injury caused by sepsis can be inhibited. The data shows that the isodan leaf emodin can relieve sepsis liver injury and reduce liver function indexes. In research, it is found for the first time that the action mechanism of the isodan-leaf emodin in relieving the sepsis liver injury is that liver function indexes and inflammatory response are relieved by inhibiting expression of a transmembrane protein intercellular adhesion molecule-1 (Icam1), and it is indicated that the isodan-leaf emodin has a good application prospect in treating sepsis-related tissue injury.
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