Application of triptolide in preparation of medicine for treating diabetic vascular obstruction complications

By using triptolide to prepare a drug composition, the problems of complexity and insufficient efficacy of existing treatments for diabetic vascular obstruction have been solved. This approach has achieved significant improvements in vascular patency, blood sugar reduction, and anti-inflammation, while also protecting pancreatic cells, providing a new monotherapy option.

CN121695148APending Publication Date: 2026-03-20FIRST AFFILIATED HOSPITAL OF GANNAN MEDICAL UNIV
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Patent Information

Application Number
CN202610111327.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-27
Publication Date
2026-03-20

AI Technical Summary

Technical Problem

Existing drug regimens for treating diabetic vascular obstruction are complex and insufficiently effective against abnormal angiogenesis and inflammatory responses driven by high glucose levels, and there is a lack of effective monotherapy options.

Method used

Tripterygium wilfordii extract was used as the active ingredient to prepare a pharmaceutical composition for the treatment of diabetic vascular obstruction. It has multiple effects such as hypoglycemic, anti-inflammatory and pancreatic cell protection. The effects of improving vascular patency and regulating the expression of inflammatory factors were verified using a zebrafish model.

Benefits of technology

Tripterygium wilfordii significantly improves vascular occlusion, lowers blood sugar levels, reduces abnormal new capillary formation, inhibits the expression of inflammatory factors, protects pancreatic cells, and provides a comprehensive regulatory advantage for the systemic treatment of diabetic vascular obstruction.

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Abstract

The invention belongs to the field of new application of medicines, and particularly relates to application of triptolide in preparation of medicines for treating diabetic vascular obstruction complications. Diabetes vascular obstruction is a common serious complication of diabetes and can cause various tissue injuries such as cardiovascular diseases, nephropathy and retinopathy. Experiments prove that the triptolide can remarkably improve the problems of blood vessel blockage, blood flow slowing, abnormal neovascularization and the like caused in a high-glucose environment, and meanwhile, the expression of blood glucose related indexes (such as Glucose and HbA1c) and inflammatory factors (such as TNF-alpha and IL-1beta) is reduced. In addition, triptolide can also protect pancreas from high glucose damage and improve functions of pancreatic beta cells. According to the invention, the clinical application range of the triptolide is expanded, and a new candidate substance is provided for drug treatment of diabetic vascular complications.
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