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Preparation method of ointment for treating infantile hemangioma

A technology for infant hemangioma and ointment, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., to improve drug efficacy, prevent blood vessel bleeding, and achieve good therapeutic effects

Inactive Publication Date: 2017-05-31
刘腾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, preclinical studies suggest that this product may produce antiviral activity by inducing cytokines including INF-α in vivo

Method used

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  • Preparation method of ointment for treating infantile hemangioma
  • Preparation method of ointment for treating infantile hemangioma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of product A: adding timolol maleate, propranolol hydrochloride, tacomus, pingyangmycin, sodium ascorbate, vitamin E and vitamin B12 into water according to a certain mass ratio, timolol maleate The mass ratio of Lol, propranolol hydrochloride, tacomus, pingyangmycin, vitamin C, vitamin E, vitamin B12 and water is 1:0.4:0.5:0.6:0.8:1:0.5:100, heated to 65°C, stirring and dissolving to obtain product A;

[0028] Preparation of ointment for treating infantile hemangioma: adding thickener, imiquimod and wetting and penetrating agent to product A according to a certain mass ratio, thickening agent, imiquimod, wetting and penetrating agent and product A The mass ratio is 0.3:0.2:1.5:100, stirred evenly, and cooled to prepare an ointment for treating infantile hemangioma.

Embodiment 2

[0030] Preparation of product A: adding timolol maleate, propranolol hydrochloride, tacomus, pingyangmycin, sodium ascorbate, vitamin E and vitamin B12 into water according to a certain mass ratio, timolol maleate The mass ratio of Lol, propranolol hydrochloride, tacomus, pingyangmycin, vitamin C, vitamin E, vitamin B12 and water is 1:0.4:0.5:0.6:0.8:1:0.5:100, heated to 65°C, stirring and dissolving to obtain product A;

[0031] Preparation of ointment for treating infantile hemangioma: adding thickener, imiquimod and wetting and penetrating agent to product A according to a certain mass ratio, thickening agent, imiquimod, wetting and penetrating agent and product A The mass ratio is 0.3:0.2:0.5:100, stirred evenly, and cooled to prepare an ointment for treating infantile hemangioma.

Embodiment 3

[0033] Preparation of product A: adding timolol maleate, propranolol hydrochloride, tacomus, pingyangmycin, sodium ascorbate, vitamin E and vitamin B12 into water according to a certain mass ratio, timolol maleate The mass ratio of Lol, propranolol hydrochloride, tacomus, pingyangmycin, vitamin C, vitamin E, vitamin B12 and water is 1:0.4:0.5:0.6:0.8:1:0.5:100, heated to 65°C, stirring and dissolving to obtain product A;

[0034] Preparation of ointment for treating infantile hemangioma: adding thickener, imiquimod and wetting and penetrating agent to product A according to a certain mass ratio, thickening agent, imiquimod, wetting and penetrating agent and product A The mass ratio is 0.3:0.2:1:100, stirred evenly, and cooled to prepare an ointment for treating infantile hemangioma.

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Abstract

The invention relates to a preparation method of an ointment for treating infantile hemangioma. The preparation method comprises the following steps: adding timolol hydrogenmaleate, propranolole hydrochloride, tacrolimus, pingyangmycin, vitamin C, vitamin E and vitamin B12 to water according to certain mass ratio, heating to 30-85 DEG C of the temperature, adding a thickener, imiquimod and a wetting agent according to certain mass ratio after stirring and dissolving, and uniformly stirring, and preparing the ointment for treating the infantile hemangioma after cooling. The ointment for treating the infantile hemangioma is an external used medicine, particularly suitable for the infants inconvenient for taking medicines and injection.

Description

technical field [0001] The invention relates to a preparation method of an ointment for treating infantile hemangioma. Background technique [0002] Hemangioma is the most common congenital benign vascular tumor in infants and young children. It occurs more frequently in women, and the male to female incidence ratio is about 1:3 to 1:4. The incidence of hemangioma in newborns is 2% to 3%, the incidence of children under 1 year old is about 10%, and the incidence of premature infants or low birth weight neonates can be as high as 22% to 30%. Hemangiomas can occur anywhere in the body, such as: skin, muscle, bone, brain, liver, heart and other organs, among which the most occur in the head and neck (60%), followed by the trunk (25%) and extremities (15%) ). Most hemangiomas can regress on their own, and the course of the disease can be divided into a proliferative phase, a regressing phase, and a regressing completion phase. Generally, the proliferative period is within 1 y...

Claims

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Application Information

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IPC IPC(8): A61K38/14A61K9/06A61P35/00A61K31/5377A61K31/138A61K31/436A61K31/375A61K31/355A61K31/714
CPCA61K9/0014A61K9/06A61K31/138A61K31/355A61K31/375A61K31/436A61K31/5377A61K31/714A61K38/14A61K47/10A61K47/26A61K47/44A61K2300/00
Inventor 刘腾
Owner 刘腾
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