A kind of traditional Chinese medicine composition for external use for treating dry eye and preparation method thereof

Abstract

The invention provides an external traditional Chinese medicinal composition for treating xerophthalmia and a preparation method thereof. The external traditional Chinese medicinal composition for treating the xerophthalmia is prepared from the following raw materials: wolfberry, chrysanthemum, salviae miltiorrhizae, cortex phellodendri, pearl powder, borneol and menthol. The external traditional Chinese medicinal composition for treating the xerophthalmia has the advantages that pathological changes of lacrimal gland tissues of an experimental xerophthalmia mouse, lacrimal glands of which are damaged by injected pingyangmycin, in morphology can be obviously alleviated, quantity of tear fluid can be obviously increased, breakup time of a tear film is prolonged, and quantity of the tear fluid secreted by a normal domestic rabbit can be obviously increased.

Description

Technical field

[0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for external use to treat dry eye syndrome. Background technique

[0002] Dry eye syndrome, also known as Xerophthalmia, is a tear and ocular surface disease caused by a variety of factors, including symptoms of ocular surface discomfort, vision changes and tear film instability and potential Ocular surface damage is accompanied by increased tear osmotic pressure and inflammation of the ocular surface. The common symptoms are: dryness, foreign body sensation, burning sensation, itching sensation, photophobia, jealousy, blurred vision, vision fluctuations, etc. Severe dry eyes can cause a significant decrease in vision, which affects their normal work and life, and even leads to blindness. At present, the conventional method of treating dry eye is to drop eye drops with lubricating function or artificial tears to relieve the symp...

Examples

Embodiment 1

[0131] 500g wolfberry, 500g chrysanthemum, 333g salvia, 500g cork, 16.7g pearl powder, 0.5g borneol, 1.0g menthol;

[0132] Preparation method: the above seven herbs, take medlar, chrysanthemum, salvia and phellodendron decocted twice with 12 times water for 1.5 hours each time, filter, and concentrate the filtrate to a relative density of 1.05-1.10 (40°C) and cool to room temperature. Add appropriate amount of ethanol to make the alcohol content reach 50%, keep it at 4°C for 12 hours, filter, and recover the ethanol to obtain the extract extract for use; take pearl powder, add 25% lactic acid, stir well, and stir every half an hour Incubate and hydrolyze at 65℃ for 2 times, 3 hours each time, filter, and the filtrate is pearl hydrolyzate for use; Beta cyclodextrin for borneol and menthol (borneol, menthol: β-CD=1: 8, β-CD (g): water (ml) = 1:10, use a colloid mill to grind for 15 minutes) for inclusion, make beta cyclodextrin inclusion compound, dry for later use; combine the ab...

Embodiment 2

[0134] 600g wolfberry, 500g chrysanthemum, 400g salvia, 520g cork, 20g pearl powder, 0.2g borneol, 6g menthol;

[0135] For the above seven medicines, take medlar, chrysanthemum, salvia, phellodendron chinense, and reflux with 50% ethanol for 3 times, each time for 1.5 hours, filter, combine the extracts, recover the ethanol to obtain the extract extract, for use; pearl powder hydrolysate and package The preparation of the compound is the same as in Example 1; the above extract extract is mixed with the pearl hydrolyzate and beta cyclodextrin inclusion compound, and then coated on a non-woven fabric to make an eye patch.

Embodiment 3

[0137] Lycium barbarum 540g, chrysanthemum 600g, Danshen 310g, cork 580g, pearl powder 16g, borneol 4g, menthol 0.6g;

[0138] For the above seven medicines, take medlar, chrysanthemum, salvia, phellodendron chinense and ultrasonically extract 3 times with 70% ethanol, each time for 40 minutes, combine the extracts, filter, concentrate the filtrate, centrifuge at 3000r / min for 15 minutes, take the supernatant, and concentrate into The extract is ready for use; the preparation of the pearl powder hydrolyzate and the inclusion compound is the same as that of Example 1; the above extract is mixed with the pearl hydrolyzate and beta cyclodextrin inclusion compound and coated on the non-woven fabric to make the eye paste.

Technical field

[0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for external use to treat dry eye syndrome. Background technique

[0002] Dry eye syndrome, also known as Xerophthalmia, is a tear and ocular surface disease caused by a variety of factors, including symptoms of ocular surface discomfort, vision changes and tear film instability and potential Ocular surface damage is accompanied by increased tear osmotic pressure and inflammation of the ocular surface. The common symptoms are: dryness, foreign body sensation, burning sensation, itching sensation, photophobia, jealousy, blurred vision, vision fluctuations, etc. Severe dry eyes can cause a significant decrease in vision, which affects their normal work and life, and even leads to blindness. At present, the conventional method of treating dry eye is to drop eye drops with lubricating function or artificial tears to relieve the symp...

Examples

Embodiment 1

[0131] 500g wolfberry, 500g chrysanthemum, 333g salvia, 500g cork, 16.7g pearl powder, 0.5g borneol, 1.0g menthol;

[0132] Preparation method: the above seven herbs, take medlar, chrysanthemum, salvia and phellodendron decocted twice with 12 times water for 1.5 hours each time, filter, and concentrate the filtrate to a relative density of 1.05-1.10 (40°C) and cool to room temperature. Add appropriate amount of ethanol to make the alcohol content reach 50%, keep it at 4°C for 12 hours, filter, and recover the ethanol to obtain the extract extract for use; take pearl powder, add 25% lactic acid, stir well, and stir every half an hour Incubate and hydrolyze at 65℃ for 2 times, 3 hours each time, filter, and the filtrate is pearl hydrolyzate for use; Beta cyclodextrin for borneol and menthol (borneol, menthol: β-CD=1: 8, β-CD (g): water (ml) = 1:10, use a colloid mill to grind for 15 minutes) for inclusion, make beta cyclodextrin inclusion compound, dry for later use; combine the ab...

Embodiment 2

[0134] 600g wolfberry, 500g chrysanthemum, 400g salvia, 520g cork, 20g pearl powder, 0.2g borneol, 6g menthol;

[0135] For the above seven medicines, take medlar, chrysanthemum, salvia, phellodendron chinense, and reflux with 50% ethanol for 3 times, each time for 1.5 hours, filter, combine the extracts, recover the ethanol to obtain the extract extract, for use; pearl powder hydrolysate and package The preparation of the compound is the same as in Example 1; the above extract extract is mixed with the pearl hydrolyzate and beta cyclodextrin inclusion compound, and then coated on a non-woven fabric to make an eye patch.

Embodiment 3

[0137] Lycium barbarum 540g, chrysanthemum 600g, Danshen 310g, cork 580g, pearl powder 16g, borneol 4g, menthol 0.6g;

[0138] For the above seven medicines, take medlar, chrysanthemum, salvia, phellodendron chinense and ultrasonically extract 3 times with 70% ethanol, each time for 40 minutes, combine the extracts, filter, concentrate the filtrate, centrifuge at 3000r / min for 15 minutes, take the supernatant, and concentrate into The extract is ready for use; the preparation of the pearl powder hydrolyzate and the inclusion compound is the same as that of Example 1; the above extract is mixed with the pearl hydrolyzate and beta cyclodextrin inclusion compound and coated on the non-woven fabric to make the eye paste.

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