Fermentation medium for producing pingyangmycin and fermentation methods

Abstract

The invention discloses a fermentation medium for producing pingyangmycin and fermentation methods. The medium comprises the following components of a nitrogen source, a carbon source, inorganic salt,trace elements and water; the nitrogen source accounts for 3.55%-9.25% of the mass of the fermentation medium; the nitrogen source comprises cold-pressed soybean cake powder and a botanical drug; thebotanical drug is one or more of ningxia chinese wolfberry, ningxia chinese wolfberry tender leaves and coix seeds; and the botanical drug accounts for 0.1%-1.5% of the mass of the fermentation medium. The carbon and nitrogen sources in the fermentation medium are agricultural and sideline products, the price is low, the chemical property is stable, the sources are wide, the transportation and storage are convenient, no toxic and harmful substance residues exist in the fermentation process, the yield of the pingyangmycin is increased, the fermentation period is shortened, and the industrial production is facilitated.

Description

technical field [0001] The invention belongs to the technical field of industrial microorganisms, in particular to a fermentation medium and a fermentation method for producing Pingyangmycin. Background technique [0002] Pingyangmycin refers to an anti-tumor antibiotic isolated from the culture solution of actinomycetes in the soil of Pingyang County, Zhejiang Province, my country. It can be used for the treatment of head and neck squamous cell carcinoma, malignant lymphoma, breast cancer, esophageal cancer and nasopharyngeal cancer, etc. It can also be used for squamous cell carcinoma of the lung, cervix and skin in other places. [0003] Relevant studies have shown that herbal medicines are rich in cellulose, starch, protein, lipids and other substances. Using herbal medicine extracts for submerged fermentation production of medicinal strains, medicinal strains have the ability to decompose cellulose, starch, protein, lipids, etc. A powerful enzyme system that can decomp...

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Problems solved by technology

[0005] The technical problem to be solved in the present invention is to overcome the low yield of Pingyangmycin produced by the fermentation process used to produce Pingyangmycin in the prior art. The preparation method of the fermentation medium with the extract as an additive is complicated, etc., and a fermentation medium and a fermentation method for the production of Pingyangmycin are provided. The carbon and nitrogen sources in the fermentation medium are agricultural by-products, the price is low, and the chemical properties Stable, wide range of sources, convenient transportation and storage, no toxic residues in the fermentation process, increase the yield of Pingyangmycin, shorten the fermentation cycle, and are suitable for industrial production

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