External traditional Chinese medicinal composition for treating xerophthalmia and preparation method thereof

A composition and traditional Chinese medicine technology, applied in the directions of drug combination, pharmaceutical formula, hydroxyl compound active ingredient, etc., can solve the problems of unfavorable active ingredient absorption, poor skin compliance of wet compress preparations, etc., to improve skin compliance and promote absorption. Effect

Active Publication Date: 2015-01-14
陕西新视明医药生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition can be made into a wet compress, but the wet compress has poor skin compliance and is not conducive to the absorption of active ingredients

Method used

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  • External traditional Chinese medicinal composition for treating xerophthalmia and preparation method thereof
  • External traditional Chinese medicinal composition for treating xerophthalmia and preparation method thereof
  • External traditional Chinese medicinal composition for treating xerophthalmia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] 500g medlar, 500g chrysanthemum, 333g salvia, 500g cork, 16.7g pearl powder, 0.5g borneol, 1.0g menthol;

[0132] Preparation method: take the above seven herbs, take medlar, chrysanthemum, salvia miltiorrhiza, and Phellodendron phellodendri, add 12 times of water to decoct twice, each time for 1.5 hours, filter, concentrate the filtrate to a relative density of 1.05-1.10 (40°C), cool to room temperature, Add an appropriate amount of ethanol to make the alcohol content reach 50%, refrigerate and stand at 4°C for 12 hours, filter, recover the ethanol to get the extract extract, and set aside; take pearl powder, add 25% lactic acid, stir well, and stir once every half an hour , hydrolyzed twice at 65°C for 3 hours each time, filtered, and the filtrate was pearl hydrolyzate for later use; beta cyclodextrin was used for borneol and menthol (borneol, menthol: β-CD=1:8, β-CD (g): water (ml)=1:10, use colloid mill to grind for 15min) to carry out inclusion complex, make beta-c...

Embodiment 2

[0134] 600g medlar, 500g chrysanthemum, 400g salvia, 520g cork, 20g pearl powder, 0.2g borneol, 6g menthol;

[0135]For the above seven herbs, take medlar, chrysanthemum, salvia miltiorrhiza, Phellodendron phellodendron and add 50% ethanol to reflux extract 3 times, each time for 1.5h, filter, combine the extracts, reclaim the ethanol to obtain the extract extract, and set aside; pearl powder hydrolyzate and package The preparation of the compound is the same as in Example 1; the above extract extract is mixed with pearl hydrolyzate and beta-cyclodextrin inclusion compound, and coated on a non-woven fabric to make an eye patch.

Embodiment 3

[0137] 540g medlar, 600g chrysanthemum, 310g salvia, 580g cork, 16g pearl powder, 4g borneol, 0.6g menthol;

[0138] For the above seven herbs, take medlar, chrysanthemum, salvia miltiorrhiza, Phellodendron phellodendri and 70% ethanol and ultrasonically extract 3 times, each time for 40 minutes, combine the extracts, filter, concentrate the filtrate, centrifuge at 3000r / min for 15 minutes, take the supernatant, and concentrate it into Extraction, for subsequent use; the preparation of pearl powder hydrolyzate and inclusion compound is the same as in Example 1; the above extract is mixed with pearl hydrolyzate and beta-cyclodextrin inclusion compound, and coated on non-woven fabric to make eye paste.

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Abstract

The invention provides an external traditional Chinese medicinal composition for treating xerophthalmia and a preparation method thereof. The external traditional Chinese medicinal composition for treating the xerophthalmia is prepared from the following raw materials: wolfberry, chrysanthemum, salviae miltiorrhizae, cortex phellodendri, pearl powder, borneol and menthol. The external traditional Chinese medicinal composition for treating the xerophthalmia has the advantages that pathological changes of lacrimal gland tissues of an experimental xerophthalmia mouse, lacrimal glands of which are damaged by injected pingyangmycin, in morphology can be obviously alleviated, quantity of tear fluid can be obviously increased, breakup time of a tear film is prolonged, and quantity of the tear fluid secreted by a normal domestic rabbit can be obviously increased.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to an external traditional Chinese medicine composition for treating dry eye. Background technique [0002] Dry eye syndrome, also known as Xerophthalmia, is a multifactorial disease of the tear fluid and ocular surface, including symptoms of ocular surface discomfort, vision changes, and tear film instability with potential Ocular surface damage, accompanied by increased tear osmolarity and ocular surface inflammation. Common symptoms are: dryness, foreign body sensation, burning sensation, itching, photophobia, red eyes, blurred vision, vision fluctuations, etc. Severe dry eye can cause significant loss of vision, which affects their normal work and life, and even leads to blindness. The current conventional method for treating dry eye is to drop eye drops with lubricating function or artificial tears to relieve symptoms. Newer treatments target the underlying cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P27/02A61K35/56A61K31/045
CPCA61K9/7023A61K31/045A61K35/618A61K36/287A61K36/537A61K36/756A61K36/815A61K2236/331A61K2236/53A61K2300/00
Inventor 张晓娟
Owner 陕西新视明医药生物科技有限公司
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