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A kind of pingyangmycin peg-pcl-peg temperature-sensitive slow-release gel and its preparation method and application

A technology of Pingyangmycin and slow-release gel, applied in the application of Pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, preparation of Pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel ,Pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel field, can solve the problems of difficult surgical resection, short residence time of Pingyangmycin, high flow rate in the tube, to prolong the half-life and action time, reduce systemic toxic and side effects, Effect of reducing drug concentration

Active Publication Date: 2014-10-01
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vascular diseases with high flow rate, such as arteriovenous malformation, usually involve arteries, and surgical resection is difficult, and the flow rate in the tube is high. Pingyangmycin stays in the diseased blood vessel for a short time, and it is difficult to achieve and maintain effective drug concentration. Therefore, clinical Treatment of superior arteriovenous malformations still needs to be improved

Method used

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  • A kind of pingyangmycin peg-pcl-peg temperature-sensitive slow-release gel and its preparation method and application
  • A kind of pingyangmycin peg-pcl-peg temperature-sensitive slow-release gel and its preparation method and application
  • A kind of pingyangmycin peg-pcl-peg temperature-sensitive slow-release gel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] A kind of Pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, which is made of the following raw materials in parts by weight:

[0058]

[0059] A kind of pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, its preparation steps are as follows:

[0060] 11g (0.01mol) ε-caprolactone (U.S. Sigma Company, analytically pure), 5.5g (0.01mol) polyethylene glycol monomethyl ether (U.S. Sigma Company, analytically pure, average molecular weight 550) and 0.08g iso Stannous octoate (Shanghai Sinopharm Chemical Reagent Co., Ltd., analytically pure, accounting for 0.5% of the total reaction system quality) was added to the reaction tube and mixed, placed in a dry nitrogen environment, and reacted at 130 ° C for 12 hours, then added 1.68 g (0.01 mol) hexamethylene diisocyanate (Sigma, USA, analytically pure), and kept stirring at 80° C. for 6 h. After the above reaction was completed, gas was pumped for 1 h under a vacuum environment, and the obtained...

Embodiment 2

[0064] A kind of Pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, which is made of the following raw materials in parts by weight:

[0065]

[0066]

[0067] A kind of pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, its preparation steps are as follows:

[0068] 11g (0.01mol) ε-caprolactone (U.S. Sigma Company, analytically pure), 5.5g (0.01mol) polyethylene glycol monomethyl ether (U.S. Sigma Company, analytically pure, average molecular weight 550) and 0.08g iso Stannous octoate (Shanghai Sinopharm Chemical Reagent Co., Ltd., analytically pure, accounting for 0.5% of the total reaction system quality) was added to the reaction tube and mixed, placed in a dry nitrogen environment, and reacted at 130 ° C for 12 hours, then added 1.68 g (0.01 mol) hexamethylene diisocyanate (Sigma, USA, analytically pure), and kept stirring at 80° C. for 6 h. After the above reaction was completed, gas was pumped for 1 h under a vacuum environment, and ...

Embodiment 3

[0071] A kind of Pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, which is made of the following raw materials in parts by weight:

[0072]

[0073] A kind of pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, its preparation steps are as follows:

[0074]11g (0.01mol) ε-caprolactone (U.S. Sigma Company, analytically pure), 5.5g (0.01mol) polyethylene glycol monomethyl ether (U.S. Sigma Company, analytically pure, average molecular weight 550) and 0.08g iso Stannous octoate (Shanghai Sinopharm Chemical Reagent Co., Ltd., analytically pure, accounting for 0.5% of the total reaction system quality) was added to the reaction tube and mixed, placed in a dry nitrogen environment, and reacted at 130 ° C for 12 hours, then added 1.68 g (0.01 mol) hexamethylene diisocyanate (Sigma, USA, analytically pure), and kept stirring at 80° C. for 6 h. After the above reaction was completed, gas was pumped for 1 h under a vacuum environment, and the obtained ...

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Abstract

The invention discloses a pingyangmycin polyethylene glycol (PEG)-polycaprolactone (PCL)-polyethylene glycol (PEG) temperature-sensitive slow-release gel, as well as a preparation method and the application of the gel. The Pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel mainly consists of two parts comprising PEG (polyethylene glycol)-PCL (polycaprolactone)-PEG (polyethylene glycol) co-polymer and Pingyangmycin, is liquid at room temperature, and is solid gel under the in vivo 37 DEG C condition; the gel system has significant slow-release effect, thereby having functions in prolonging the half-life period and the acting time of the Pingyangmycin, reducing drug concentration in plasma, and reducing systemic toxic and side effects. The gel can be formed in situ after the medicine is injected in a high-flow-speed vessel, and then location embolism is realized, and so as to realize the, and muscularization and closing of muscle is caused, so that the sclerotherapy and the interventional therapy are combined effectively, the gel has excellent biocompatibility and degradability, is beneficial for treating hemangiomas, vascular malformations and cancers, particularly, a new selection is provided to the treatment of the vein malformation and partial malformation of cancers.

Description

technical field [0001] The present invention relates to the technical field of new dosage forms and preparations of biology and medicine, more specifically to a pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel, and also to a pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel. The preparation method of the release gel is simple and easy to implement. It also relates to the application of a pingyangmycin PEG-PCL-PEG temperature-sensitive slow-release gel. The new dosage form of pingyangmycin prepared by the invention provides a new choice for the preparation of local chemotherapy drugs for treating arteriovenous malformations and malignant tumors. Background technique [0002] Vascular disease is the most common benign tumor or congenital malformation in human soft tissue, especially in infants and young children. It often invades the facial skin, causing facial deformity and dysfunction, and can cause secondary infection and bleeding, which is h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/14
Inventor 陈刚冯俊任建岗王华芬张伟贾俊孙志军
Owner WUHAN UNIV
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