Method for purifying protopine from corydalis amabilis
A purification method and proto-opioid technology, applied in ultrafiltration, organic chemistry and other directions, can solve the problems of many toxic reagents and low resin specificity, and achieve the effects of increasing speed, reducing loss and increasing adsorption capacity.
CN101805345AInactive Publication Date: 2010-08-18NANJING ZELANG MEDICAL TECH
Patent Information
- Authority / Receiving Office
- CN Β· China
- Current Assignee / Owner
- NANJING ZELANG MEDICAL TECH
- Publication Date
- 2010-08-18
- Estimated Expiration
- Not applicable Β· inactive patent
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Figure 1
Abstract
The invention relates to a protopine extraction purification method with simple operation and low cost. The technology includes that corydalis amabilis medicinal material with high content of protopine is taken as raw material, smashing is carried out, ethanol reflux extraction is carried out for 2-3 times, reduced pressure concentration is carried out to low alcohol and acetic acid is added for fluxing, compound ultrafiltration membrane is used for holding back macromolecule impurity, then mixed resin is used for enrichment, gradient elution is carried out for removing impurities, protopine eluent is collected, ammonia water is used for regulating pH value, crystallization is carried out, crude crystal is separated, ethanol and ethanol chloroform are used for carrying out step recrystallization. By adopting the method to produce product, period is short, and yield is high. The technology is easy to be amplified and industrialized.
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Claims
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