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Refined rhizoma corydalis decumbentis total alkaloid product, preparation method thereof, pharmaceutical composition and application of refined rhizoma corydalis decumbentis total alkaloid product and pharmaceutical composition

A technology for total alkaloids and medicines, which is applied in the field of refined products without total alkaloids in summer, can solve problems such as unsuitability for medicinal use, high impurity content, and complicated steps, and achieve safe and effective pharmacological efficacy, high purity, and scientific and efficient purity. Effect

Inactive Publication Date: 2016-02-10
SHANGHAI INST OF PHARMA IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to overcome the defects of the existing summer-free total alkaloid extraction method, such as cumbersome steps, low extraction rate, low purity of the extracted extract, high impurity content, unsuitable for medicinal use, and unsuitable for industrial production. , and provide a summer free total alkaloid refined product, preparation method, pharmaceutical composition and application

Method used

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  • Refined rhizoma corydalis decumbentis total alkaloid product, preparation method thereof, pharmaceutical composition and application of refined rhizoma corydalis decumbentis total alkaloid product and pharmaceutical composition

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Experimental program
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Effect test

Embodiment 1

[0035] Embodiment 1: Preparation of total alkaloid-free refined product in summer

[0036] Get the dry tuber that does not have in summer, pulverize, and obtain particle size and be 10 order ~ 40 order medicinal material powder; Get medicinal material powder 300g, add volume ratio and be 6% ammoniacal liquor as alkalizing agent (described volume ratio refers to that the volume of ammoniacal liquor reagent occupies ammonia The percentage of the total volume of the aqueous solution, the mass concentration of the ammonia reagent is 25% to 28%, the mass concentration refers to the percentage of the quality of ammonia gas in the total mass of the ammonia reagent), and the dosage is 50% of the weight of the summer non-medicinal material, soaked for 2h ;Put medicinal materials into supercritical CO 2 In an extractor coupled with extraction and membrane (ultrafiltration membrane with a pore size of 0.8 μm), methanol is used as an entrainer, and after 30 minutes of extraction, the extr...

Embodiment 2

[0037] Embodiment 2: Preparation of total alkaloid-free refined product in summer

[0038] Get the dry tuber that does not have in summer, pulverize, and obtain the medicinal material powder that particle size is 20 order~40 order; Get medicinal material powder 300g, add volume ratio and be 10% ammoniacal liquor as alkalizing agent (described volume ratio refers to that the volume of ammoniacal liquor reagent occupies ammonia The percentage of the total volume of the aqueous solution, the mass concentration of the ammonia water reagent is 25% to 28%, and the mass concentration refers to the percentage of the quality of ammonia gas in the total mass of the ammonia water reagent), and the dosage is 60% of the weight of the summer non-medicinal material, soaked for 1h ;Put medicinal materials into supercritical CO 2 In the extractor of extraction and membrane coupling (using a nanofiltration membrane with a pore size of 2 nanometers), 95% ethanol is used as an entrainer in a mass...

Embodiment 3

[0039] Embodiment 3: the preparation method of total alkaloid-free refined product in summer

[0040] Get the dry tuber that does not have in summer, make powder, and obtain particle size and be 10 order ~ 20 order medicinal material powder; Get medicinal material powder 200g, add volume ratio and be 7% ammoniacal solution as alkalizing agent (the volume ratio refers to the volume of ammonia water reagent accounts for The percentage of total volume of ammonia solution, the mass concentration of ammonia reagent is 25%~28%, described mass concentration refers to the percentage of the quality of ammonia gas accounting for the total mass of ammonia reagent), and the consumption is 50% of the summer non-medicinal weight, infiltrating 3h; put medicinal materials into supercritical CO 2 In the extractor of extraction and membrane coupling (using a hollow fiber membrane with a pore size of 0.1 micron), 95% ethanol is used as an entrainer in a mass percentage (the mass percentage refer...

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Abstract

The invention discloses a refined rhizoma corydalis decumbentis total alkaloid product, a preparation method thereof, a pharmaceutical composition and application of the refined rhizoma corydalis decumbentis total alkaloid product and the pharmaceutical composition. The refined rhizoma corydalis decumbentis total alkaloid product comprises, by weight, 15%-40% of protopine, 10%-40% of tetrahydropalmatine, 0-10% of bicuculline, 0.01%-2% of palmatine hydrochloride, 2%-10% of kikemanine, 15%-30% of egenine and 1%-5% of other alkaloids and extracts. The more scientific and efficient, simple, convenient and feasible method for extracting high-purity rhizoma corydalis decumbentis total alkaloids is established, and HPLC (high performance liquid chromatography) purity of the prepared refined rhizoma corydalis decumbentis total alkaloid product is above 98%, so that pharmacology and efficacy of the rhizoma corydalis decumbentis total alkaloids can be given to play more safely and effectively.

Description

technical field [0001] The present invention relates to summer free total alkaloid refined product, preparation method, pharmaceutical composition and application. Background technique [0002] Summer Wu is the dried tuber or whole plant of Corydalis decumbens (Thunb.) Pers., a plant of the genus Corydalis of the family Papaveraceae. It is mainly used for the treatment of stroke and hemiplegia caused by high blood pressure and cerebrovascular disease, and has a good effect on rheumatoid arthritis, sciatica, and sequelae of polio. Its main active ingredients are total alkaloids of isoquinolines. Literature data show that more than 30 isoquinoline alkaloids have been isolated from Xia Wu, mainly containing protopine, tetrahydropalmatine, bicuculline, and palmatine , jatrorrhizine and other alkaloids. [0003] At present, the commonly used extraction and refining methods of summer non-alkali include water extraction and alcohol precipitation, percolation, alcohol extraction,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P9/10A61P25/00
Inventor 杨义芳黄春跃
Owner SHANGHAI INST OF PHARMA IND
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