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Use of protopine total alkaloids in animal drugs for economic animals

A technology of total alkaloids and categories, which is applied in the field of total alkaloids of tropes, can solve the problems of high recurrence rate, affecting the quality and hygiene of meat and egg food, and drug residues, and achieves improved feed conversion rate and good anti-parasitic effect. , the effect of good market prospects

Active Publication Date: 2009-09-02
MICOLTA BIORESOURCE INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the disease can be controlled and improved by using a lot of drugs, treating the symptoms alone, not the root cause, can only control the disease, the recurrence rate is high and drug residues are caused, which seriously affects the quality and hygiene of meat and egg food

Method used

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  • Use of protopine total alkaloids in animal drugs for economic animals
  • Use of protopine total alkaloids in animal drugs for economic animals
  • Use of protopine total alkaloids in animal drugs for economic animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take boluo back to the fruit pods, extract with 20 times the amount of 1% sulfuric acid aqueous solution, then adjust the pH to 8-10 with sodium hydroxide, after separating the precipitate, absorb the filtrate on the macroporous resin, and then wash it with 10% ethanol Take off, then elute with 80% ethanol, collect 80% ethanol eluate, concentrate and dry to obtain the total alkaloid plant extract of general class class, measure the total biological content of general class class through HPLC and be about 71.9% (with original opioid and The total content of allocryptine, the same below), among which the original opium is about 46.3%, and the other cryptopine is about 25.6%.

Embodiment 2

[0019] 32 breeds were selected as Bailaihang backup hens, and the age was 148 days. Divide into 4 groups with 8 chickens in each group, and use the MacMaster method to confirm that all chickens are infected with chicken Ascaris and Heterocarpus chicken before deworming. The total alkaloids of Putuo class obtained in Example 1 were mixed into the feed with dosages of 1ppm, 2.5ppm and 5ppm respectively to control the blank group, and fed once. After deworming, wash and settle with water every day to find out the expelled insects. On the 4th day after deworming, all the chickens were slaughtered, and the residual insects in the digestive tract were collected, and the rough deworming rate and fine deworming rate were calculated. The experimental results show that the total alkaloids of Putuo can effectively remove roundworms and Heterocarpi nematodes in chickens. During the whole test period, the chickens had a normal appetite and no side effects were observed.

[0020] Table 1 D...

Embodiment 3

[0024] 14 naturally infected piglets were selected by the MacMaster method from the breed Du × Chang × Big pigs raised in the pig farm, with an average body weight of 16 kg, and free drinking water during the test period. The test animals were not limited in sex, and were randomly divided into two groups, 7 in each group. The first group was treated with abamectin, and the second group was treated with the total alkaloids of the protopol class obtained in Example 1. Before the test and on the 5th day after the treatment, the eggs were counted head by head with the McMaster method, and the average value of EPG (the number of eggs per gram of feces) was calculated. On the 10th day after the administration, eggs were found by sedimentation and floating egg collection methods.

[0025] Table 2 Inspection results of test insect eggs

[0026]

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PUM

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Abstract

The invention discloses the use of protopine total alkaloids in animal drugs for economic animals. The protopine total alkaloids are used as active ingredients in the preparation of animal drugs for expelling the eelworms in the alimentary canals of economic animals. The protopine total alkaloids are extracted from plants of macleaya cordata, macleaya microcarpa, eomecon chionantha hance, greater celandine herb. Researches on the biological activities of the protopine total alkaloids show that the protopine total alkaloids have effects of widely expelling eelworms in alimentary canals, promoting the growth of the economic animals and improving feed conversion rate.

Description

Technical field: [0001] The present invention relates to a general class of Puto products with anti-nematode effect extracted from plants containing benzylisoquinoline Alkaloid - Boluohui, Xiaoguoboluohui, Xueshuicao and Celandine. Alkaloids, which have a good application in repelling nematode diseases of economic animals pigs and chickens. Protopine alkaloids are mainly represented by Protopine and Allocryptopine. Background technique: [0002] At present, the global animal epidemic is in an active period, and pathogens circulate and spread between humans and animals, making the public health problem of animal epidemics increasingly prominent. Breeding patterns, changes in the ecological environment, and the transmission of pathogens between multiple hosts all affect the prevalence of animal diseases, and present new epidemic characteristics. With the development of my country's animal husbandry and breeding industry, intestinal parasitic diseases of livestock and poultry...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K31/395A61P33/10
Inventor 曾建国
Owner MICOLTA BIORESOURCE INC LTD
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