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Total alkaloid of xiatianwu (a Chinese medicinal material), its preparation method and application

A technology of total alkaloids and plants, which is applied in the direction of drug combinations, pharmaceutical formulas, active ingredients of heterocyclic compounds, etc., and can solve problems such as unclear content, difficult control of internal quality, rough process, etc.

Inactive Publication Date: 2008-10-08
湖南医药工业研究所有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process of these preparations is quite rough, and the content is not very clear, and the internal quality is difficult to control

Method used

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  • Total alkaloid of xiatianwu (a Chinese medicinal material), its preparation method and application
  • Total alkaloid of xiatianwu (a Chinese medicinal material), its preparation method and application
  • Total alkaloid of xiatianwu (a Chinese medicinal material), its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Embodiment 1: A kind of summer without total alkaloid, its weight ratio component comprises protopine 45%, tetrahydropalmatine 15%, palmatine 20%, bikukuling 5%, other alkaloids and extract 15%.

example 2

[0094] Example 2 (preparation method):

[0095] Take 1 kg of summer crude drug coarse powder, add 3 kg of 2% phosphoric acid (hydrochloric acid or sulfuric acid or acetic acid) solution to soak overnight, put it into a diafiltration cartridge, use 2% of the above solution for diafiltration, collect the leachate until the alkaloid reaction is until a negative reaction. The leachate is adjusted to a pH value of about 6 with 10% sodium hydroxide, and then concentrated to 0.4 g crude drug / ml.

[0096] for separation.

[0097] Get the concentrated solution, and the upper column bed volume is the macroporous adsorption resin AB-8 (or D 201 、D 3520 、D 4020 、D 101 、H 103 ) was eluted with 1N NaOH solution until the color was light, and then washed with distilled water until neutral. Then eluted with 50-95% ethanol, and the eluate was collected until the alkaloid reaction was negative, and the ethanol was recovered from the eluate to Alcohol-free, use 10% sodium hydroxide solution...

Embodiment 3

[0099] Embodiment 3 (preparation method):

[0100] Take 1 kg of crude drug powder in summer, mix well with concentrated ammonia water, dry it in air, add 3 kg of 90% ethanol to soak overnight, put it into a diafiltration cartridge, use 90% ethanol for diafiltration, collect the leachate until the alkaloid reaction becomes Until negative reaction, reclaim ethanol until there is no alcohol, adjust pH5 to 6 with 1% phosphoric acid (sulfuric acid or hydrochloric acid or acetic acid) solution of extract, volume is about 3000 milliliters, let stand overnight, get supernatant for subsequent use.

[0101] Get above-mentioned extraction solution, the macroporous adsorption resin AB-8 (D 101 or D 201 、D 3520 、D 4020 、H 103 ) was eluted with 1% NaOH solution until the color was light, and then washed with distilled water until neutral. Then, eluted with 50-95% alcohol, collected the eluate until the alkaloid reaction was negative, and recovered ethanol from the eluate To no alcohol,...

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Abstract

The present invention relates to total alkaloid of Chinese medicinal material corydalis amabilis, its preparation method and application in medicine. Said total alkaloid mainly includes protopine 25-65%, tetrahydropalmatine 10-25%, bikukuling 5-10% and palmatine 10-20% and other alkaloid and extract 5-20%. Its preparation method includes the following steps: using corydalis amabilis as raw material, adding proper quantity of polar solvent, making diacolation extraction, collecting diacolate until there is not alkaloid reaction, combining diacolates, concentrating to obtain concentrate, making said concentrate pass through macroporous adsorption resin to make adsorption chromatography, using soda lye to make elution and remove impurity or using resin to adsorb impurity, using polar eluent to total alkaloid of corydalis amabilis, collecting eluent, recovering solvent, concentrating and crystallizing so as to obtain the invented product. Said invention also provides its application for preparing medicine.

Description

technical field [0001] The invention relates to a total alkaloid prepared from the traditional Chinese medicine Xia Wu for promoting qi, activating blood circulation, dredging collaterals and relieving pain and a preparation method thereof, and the application of the total alkaloid in medicines. Background technique [0002] Chinese medicine Xia Wuwei is the dry tuber of Corydalis decumbens (Thunb) pers, a plant of the poppy family. It is a commonly used medicine for promoting qi and blood circulation, dredging collaterals and analgesics, and can be used for stroke hemiplegia, injury from falls, rheumatoid arthritis, sciatica, etc. Treatment of many blood circulation disorders. Clinically, there is no decoction or powder used as medicine in summer. [0003] At present, there are Xiawu Tablets and Xia Tian Wu Injection produced and marketed at home and abroad. Xia Tian Wu Tablets are made by mixing, granulating and tableting the original medicinal material Xia Wu powder and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/153A61K31/395A61K31/44A61P29/00A61P19/02A61P9/10A61P25/02
CPCY02A50/30
Inventor 林海康建南李梅连黎格勒肖艳萍郑正春魏云黄河清黄云周海波
Owner 湖南医药工业研究所有限公司
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