Hotseason grow corydaline, its preparation method and its medicinal composition
A technology of fusheng violet and a composition, which is applied in the application field of preparing medicines for treating and preventing acute cerebral ischemia, can solve the problems of inability to quantify, the content of toxic components is higher than that of kukuling, and the clinical application is limited, and the operation is achieved. Simple, low content of highly toxic ingredients, safe drug effect
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Embodiment 1
[0068] Example 1 Preparation of total alkaloids of Corydalis fuscens
[0069] (1) Take 1 kg of crude drug crude powder of Corydalis viridifera tuber, add 3 kg of 2% phosphoric acid solution to soak overnight, put it into a diafiltration cartridge, diafilter with 2% phosphoric acid solution, collect the leachate until the alkaloid reaction is negative response. The leachate is adjusted to a pH value of about 6 with 10% sodium hydroxide, and then concentrated to 1 gram of crude drug / ml. for separation purposes;
[0070] (2) Get the concentrated solution, and the upper column bed volume is 2000 milliliters of macroporous adsorption resin DM 301 , wash with 45°C 2N NaOH solution (2000-4000ml) until the color is light, and then wash with distilled water (5000-10000ml) until neutral. Then use 50% ethanol (1000-3000ml) to wash until extremely dry;
[0071] (3) Elution with 95% ethanol containing 0.3% phosphoric acid (2000-3000ml), collect the eluent and wash until the alkaloid re...
Embodiment 2
[0084] Example 2 Preparation of total alkaloids of Corydalis fuscens
[0085] The polar solvent used in step (1) in Example 1 is replaced with 2% hydrochloric acid solution, and other steps (2), (3), (4), and (5) are completely the same as in Example 1.
[0086] Measure and calculate by the content determination method in the embodiment 1 and get the total alkaloids of Corydalis fusumi to be 84.2%, the original opiate content is 35.6%, and the content of bikuling is 4.5%.
Embodiment 3
[0087] Example 3 Preparation of total alkaloids of Corydalis fuscens
[0088] The polar solvent used in step (1) in embodiment 1 is replaced with 2% sulfuric acid solution, and other steps (2), (3), (4), and (5) are completely the same as in embodiment 1.
[0089] Measure and calculate by the content determination method in the embodiment 1 and get the total alkaloids of Corydalis fusumi to be 82.5%, the original opioid content is 35.7%, and the content of bikuling is 4.8%.
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