Hotseason grow corydaline, its preparation method and its medicinal composition

A technology of fusheng violet and a composition, which is applied in the application field of preparing medicines for treating and preventing acute cerebral ischemia, can solve the problems of inability to quantify, the content of toxic components is higher than that of kukuling, and the clinical application is limited, and the operation is achieved. Simple, low content of highly toxic ingredients, safe drug effect

Active Publication Date: 2006-06-14
河北智源医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the different techniques, there are also great differences in the internal components. No matter which extraction method has the disadvantage that the content of toxic components is higher than that of Kukuling and cannot be quantified, so there is no total alkaloid in summer. It has potential safety hazards and its clinical application is limited

Method used

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  • Hotseason grow corydaline, its preparation method and its medicinal composition
  • Hotseason grow corydaline, its preparation method and its medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1 Preparation of total alkaloids of Corydalis fuscens

[0069] (1) Take 1 kg of crude drug crude powder of Corydalis viridifera tuber, add 3 kg of 2% phosphoric acid solution to soak overnight, put it into a diafiltration cartridge, diafilter with 2% phosphoric acid solution, collect the leachate until the alkaloid reaction is negative response. The leachate is adjusted to a pH value of about 6 with 10% sodium hydroxide, and then concentrated to 1 gram of crude drug / ml. for separation purposes;

[0070] (2) Get the concentrated solution, and the upper column bed volume is 2000 milliliters of macroporous adsorption resin DM 301 , wash with 45°C 2N NaOH solution (2000-4000ml) until the color is light, and then wash with distilled water (5000-10000ml) until neutral. Then use 50% ethanol (1000-3000ml) to wash until extremely dry;

[0071] (3) Elution with 95% ethanol containing 0.3% phosphoric acid (2000-3000ml), collect the eluent and wash until the alkaloid re...

Embodiment 2

[0084] Example 2 Preparation of total alkaloids of Corydalis fuscens

[0085] The polar solvent used in step (1) in Example 1 is replaced with 2% hydrochloric acid solution, and other steps (2), (3), (4), and (5) are completely the same as in Example 1.

[0086] Measure and calculate by the content determination method in the embodiment 1 and get the total alkaloids of Corydalis fusumi to be 84.2%, the original opiate content is 35.6%, and the content of bikuling is 4.5%.

Embodiment 3

[0087] Example 3 Preparation of total alkaloids of Corydalis fuscens

[0088] The polar solvent used in step (1) in embodiment 1 is replaced with 2% sulfuric acid solution, and other steps (2), (3), (4), and (5) are completely the same as in embodiment 1.

[0089] Measure and calculate by the content determination method in the embodiment 1 and get the total alkaloids of Corydalis fusumi to be 82.5%, the original opioid content is 35.7%, and the content of bikuling is 4.8%.

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Abstract

A corydaline for preparing medicines to prevent and treat acute cerebral sichemia is prepared from the drived tuber of corydalis, and contains protopine, bicuculline, tetraphdropalmatine, palmatine, etc. Its preparing process and its composite medicine are also disclosed.

Description

technical field [0001] The present invention relates to total alkaloids of Corydalis virgines, its preparation method, its pharmaceutical composition, and its application in the preparation of medicines for treating and preventing acute cerebral ischemia. Background technique [0002] The dry tuber of Corydalis decumbens (Thunb) pers, a plant of the family Poppyaceae, is a commonly used drug for promoting qi and blood circulation, dredging collaterals and analgesic, and its Chinese name is Xia Wu. It can be used for the treatment of many blood circulation disorder diseases such as stroke hemiplegia, bruises, rheumatoid arthritis, sciatica, etc. At present, there are Xiawu Tablets and Xia Tian Wu Injection produced and marketed at home and abroad. Xia Tian Wu Tablets are made by mixing, granulating and tableting the original medicinal material Xia Wu powder and its alcohol extract; the injection is made from the original medicinal material Xia Tian Wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P9/10C07D491/153C07G5/00
Inventor 夏彤魏兵黄国胜胡竹梅王海强
Owner 河北智源医药科技有限公司
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