Decumbent corydalis tuber eye drop and preparation method thereof
A technology for eye drops and solutions, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. problem, to solve the irritating problem, the product has good stability, and avoid excessive degradation.
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Embodiment 1
[0057] 【prescription】
[0058] No extract in summer, containing 0.375g of pro-opiate
[0059] Natural Borneol 0.25g
[0060] Sodium dihydrogen phosphate 1.0g
[0061] Anhydrous disodium hydrogen phosphate Adjust pH to 5.8
[0062] Glycerin Adjust osmolarity to 0.29 Osmol / kg
[0063] Polysorbate 80 5.0g
[0064] Edetate Disodium 0.5g
[0065] Ethylparaben 0.5g
[0066] Sodium Hyaluronate 1.0g
[0067] Medicinal ethanol 2ml
[0068] Add water for injection to make 1000ml
[0069] Preparation:
[0070] (1) Weigh Xiaxiawu extract according to the amount of 0.375g of the original opioid, add it to 400ml 0.01mol / L dilute phosphoric acid solution, stir at 90°C for 10 minutes, then add the polysorbate 80 5g to it , stirred, dissolved, and kept at 90°C for 30 minutes, set aside;
[0071] (2) Add 1g of sodium dihydrogen phosphate, 0.5g of edetate disodium, 0.5g of ethylparaben, and glycerin into 300ml of water for injection heated to 90°C, stir to dissolve, and cool to 50°C; ...
Embodiment 2
[0077] 【prescription】
[0078] No extracts in summer, containing 0.355g of pro-opiate
[0079] Sodium dihydrogen phosphate 3.0g
[0080] Anhydrous disodium hydrogen phosphate Adjust the pH to 4.6
[0081] Glycerin Adjust osmolality to 0.28 Osmol / kg
[0082] Polysorbate 80 3.0g
[0083] Edetate Disodium 0.3g
[0084] Ethylparaben 0.1g
[0085] Add water for injection to make 1000ml
[0086] Preparation:
[0087] (1) Weigh Xiaxiawu extract according to the amount of 0.355g of the original opioid, add it to 400ml 0.01mol / L phosphoric acid solution, stir at 90°C for 10 minutes, add 3.0g of polysorbate 80 in the prescription amount, stir Dissolve and keep warm at 90°C for 30 minutes, set aside;
[0088] (2) Add 3.0 g of sodium dihydrogen phosphate, 0.3 g of disodium edetate, 0.1 g of ethylparaben and glycerin into 300 ml of water for injection heated to 90°C, stir to dissolve, and let cool to about 50°C; The above two solutions were mixed and cooled to room temperature. R...
Embodiment 3
[0091] 【prescription】
[0092] No extracts in summer, containing 0.395g of pro-opiate
[0093] Natural borneol 0.5g
[0094] Sodium dihydrogen phosphate 2.0g
[0095] Anhydrous disodium hydrogen phosphate Adjust pH to 5.0
[0096] Glycerin Adjust osmolarity to 0.31 Osmol / kg
[0097] Polysorbate 80 5.0g
[0098] Edetate Disodium 0.8g
[0099]Ethylparaben 0.8g
[0100] Sodium Hyaluronate 2.0g
[0101] Medicinal ethanol 3ml
[0102] Add water for injection to make 1000ml
[0103] The preparation method is similar to Example 1.
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