The invention discloses a composition with sterilization and disinfection effects. The composition is prepared from herba euonymi, fiveleaf gynostemma herb, inula herb, bunge corydalis herb, herba hyperici perforati, rhizoma rodgersiae aesculifoliae, patrinia heterophylla bunge root, rhizoma et radix patriniae, herba lysimachiae capillipe, rosemary herb, flos caryophylli, sugarcane juice, EM (effective microorganisms) original liquid, and the like, wherein the herba euonymi, fiveleaf gynostemma herb have the functions of promoting Qi circulation and activating blood circulation, clearing heat, supplementing deficiency and detoxifying, adjusting immunity, and resisting oxidizing, are human body strengthening products with clearing and tonifying effects, and are used for strengthening physique to prevent the invasion of bacteria virus; the inula herb, the bunge corydalis herb, the rhizoma rodgersiae aesculifoliae, dark plum, and the patrinia heterophylla bunge root have the functions of clearing heat, detoxifying, cooling blood and stopping bleeding, eliminating swelling and relieving pain, treating cough, inhibiting multiple types of bacteria viruses, resisting inflammation, easing pain, protecting liver, and promoting immunity. The composition has the advantages that the compounding of Chinese herbal medicines is scientific and reasonable, the broad-spectrum sterilization and disinfection effects are strong, the sterilizing capability is strong and quick, the pests and foreign odor are expelled, the air is refreshed, and the effects of killing insects, relieving itching, stopping bleeding, eliminating swelling, retracting muscles, and the like on skin of a human body are realized.