Timolol maleate cubic liquid crystal nanoparticle eye drops and preparation method thereof

A timolol maleate and nanoparticle technology, which is applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of timolol maleate eye drops To solve the problems of short eye retention time, irritation, and short retention time of drugs in the eyes, etc., it can improve drug compliance, maintain moisture, and increase corneal penetration.
CN106619573BActive Publication Date: 2019-09-20GUANGZHOU NEWORLD PHARMA CO LTD
8 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGZHOU NEWORLD PHARMA CO LTD
Publication Date
2019-09-20

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to timolol maleate cubic liquid crystal nanoparticle eye drops and a preparation method thereof. The imolol maleate cubic liquid crystal nanoparticle eye drops are mainly prepared from, by weight, 0.4-1.0 part of timolol maleate, 1.0-18.0 parts of liquid crystal material, 0.2-3.0 parts of surface active agent and 100 parts of water. The liquid crystal material is glycerol monoolein. The surface active agent is poloxamer. According to the timolol maleate cubic liquid crystal nanoparticle eye drops, the cornea infiltration capacity of timolol maleate can be remarkably improved, intra-ocular pressure can be remarkably and stably reduced, the retention time of a drug in the eyes can be prolonged, no preservative is added, and the problems that in the prior art, the retention time of timolol maleate eye drops in the eyes is short and irritation is caused by long-time use can be effectively solved.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a timolol maleate cubic liquid crystal nanoparticle eye drop and a preparation method thereof. Background technique

[0002] Glaucoma is an eye disease characterized by optic neuropathy and loss of visual function. Elevated intraocular pressure is the main blinding factor of glaucoma, and drug therapy is the main treatment. At present, the clinical medicine for glaucoma is mainly based on eye drops, including Ξ²-receptor antagonists, prostaglandin analogs, carbonic anhydrase inhibitors, adrenergic receptor agonists, choline receptor agonists and optic nerve protection drugs, etc. . Although prostaglandin analogues, such as latanoprost, bimatoprost and travoprost, are increasingly listed as clinical first-line drugs in Europe, America and other countries, the high price will increase the cost of long-term medication for patients. The economic burden limits its use as th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More