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Pharmaceutical composition for wound treatment and repair and preparation method of composition

A composition and medicine technology, applied in the directions of medicine combination, medicine formula, active ingredient of iodine compound, etc., can solve the problem of general bacteriostatic effect, etc., and achieve the effects of long healing time, simple preparation method and remarkable effect.

Inactive Publication Date: 2020-06-02
苏州沃立医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when chitosan oligosaccharide is applied to the wound alone, its antibacterial effect is general

Method used

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  • Pharmaceutical composition for wound treatment and repair and preparation method of composition
  • Pharmaceutical composition for wound treatment and repair and preparation method of composition
  • Pharmaceutical composition for wound treatment and repair and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 iodo-oligochitosan

[0019] Dissolve chitosan 10g (derived from Alaska white crab, deacetylation degree 90%, moisture 4.9%, ash content 0.5%, viscosity average molecular weight 100,000) with acetic acid 333ml, chitosan concentration is 0.03g / ml, add apple Hydrolyze 5ml of mixed enzyme composed of protease and endo-chitosaccharidase, adjust the pH value to 6.0 after hydrolysis for 30mim, continue to degrade at 65°C for 4h, inactivate the enzyme at 110°C for 15min, centrifuge to obtain the supernatant, freeze-dry (-50°C, 10Pa ), to obtain solid powder 9.17g. Through HPLC test, it is confirmed that it is oligomeric chitosan, the average molecular weight is 1350, and the purity is more than or equal to 99%. Another 6 g of iodosuccinimide (NIS) and 6 g of chitosan oligosaccharides were dissolved in 500 ml of absolute ethanol, and slowly stirred at 65° C. for 24 h. After the reaction, distill under reduced pressure (50°C, 10kPa) to form syrup...

Embodiment 2

[0020] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0021] The average molecular weight of iodo-oligochitosan is 1480, and the purity is more than or equal to 99%. It is prepared in Example 1.

[0022] Carbomer, triethanolamine, Tween 80, glycerin, and menthol are all commercially available, and distilled water is self-made (stainless steel electric water distiller, model: YN-ZD-20).

[0023] After swelling with 3g of carbomer and 60g of distilled water for 6 hours, slowly add 2g of triethanolamine, 2g of Tween 80, and 8g of glycerin while stirring, and stir for 12 hours. Another 1.5g of menthol and 5g of iodo-oligochitosan were dissolved in 18.5g of distilled water, stirred to fully dissolve, then slowly added to the above-mentioned colloid, stirred evenly, to obtain the sol of the pharmaceutical composition.

Embodiment 3

[0024] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0025] The average molecular weight of iodo-oligochitosan is 1480, and the purity is more than or equal to 99%. It is prepared in Example 1.

[0026] Carbomer, triethanolamine, Tween 80, glycerin, and menthol are all commercially available, and distilled water is self-made.

[0027] After swelling with 2g of carbomer and 60g of distilled water for 6 hours, slowly add 3g of triethanolamine, 3g of Tween 80, and 5g of glycerin while stirring, and stir for 12 hours. Another 1g of menthol and 9g of iodo-oligochitosan were dissolved in 17g of distilled water, stirred to fully dissolve, then slowly added to the above-mentioned colloid, and stirred evenly to obtain the sol of the pharmaceutical composition.

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Abstract

The invention discloses a pharmaceutical composition for wound treatment and repair. The pharmaceutical composition is composed of the following components in percentages by weight: 1%-10% of iodo-oligochitosan, 1%-5% of carbomer, 1%-3% of triethanolamine, 1%-5% of Tween 80, 5%-10% of glycerol, 1%-2% of menthol, and 65%-90% of distilled water. Results of antibacterial experiments of the composition provided by the invention show that the composition has strong antibacterial ability against staphylococcus aureus, escherichia coli and candida albicans; and animal experiments and clinical experiments prove that the pharmaceutical composition provided by the invention has a remarkable effect on repairing wounds, so that the composition can be used for wound treatment and repair. The preparation method provided by the invention is simple, and suitable for industrial production, and has great clinical application value and social benefits.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for wound treatment and repair. Background technique [0002] Iodine is an essential trace element for human activities. In the field of medicine, iodine can be made into iodine and iodophor, which is generally used as a material for surgical disinfection, but there are common problems such as irritation or slow wound recovery. Chitosan oligosaccharide is a secondary product of chitosan. Compared with chitosan, it has a lower degree of polymerization, higher water solubility, and lower molecular weight. It has various physiological activities such as antibacterial, anti-inflammation, anti-infection, and immune enhancement. However, when chitosan oligosaccharide is applied to the wound alone, its antibacterial effect is average. [0003] The inventors found that chitosan oligosaccharides reacted with iodosuccinimide (NIS) under specific conditio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K31/722A61K47/32A61K47/26A61K47/10A61P31/04A61P17/02
CPCA61K31/722A61K33/18A61K47/10A61K47/26A61K47/32A61P17/02A61P31/04A61K2300/00Y02A50/30
Inventor 钱峰李明王卫华张雪华张建平陆昊
Owner 苏州沃立医疗科技有限公司
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