Capparis spinosa fruit gel ointment, production method thereof, and application thereof to antirheumatic medicaments

A technology of gel ointment and capers, which is applied in the field of medicine, can solve problems such as skin irritation, and achieve the effects of long-lasting effect, safe use, and shortened production cycle

Active Publication Date: 2012-11-14
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, if the safety issues such as skin irritation and allergies in the utilization of capers can be solved, and a safe and effective caper fruit preparation can be provided clinically, it will become a technology to be overcome urgently in pharmacy research. difficulty

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, the caper fruit gel ointment comprises a backing layer, a medicated ointment and a cover lining layer protective film, and the medicated ointment is produced by the following raw material weight percentages: 10% to 60% of caper fruit The medicinal part and the remaining pharmaceutical excipients; the backing material used in the backing layer is one of cotton cloth, non-woven fabric, and chemical fiber cloth; the cover lining material used in the protective film of the cover lining layer is anti-adhesive One of paper, plastic film, polyester, aluminum foil-polyethylene composite film, hard gauze.

Embodiment 2

[0029] Example 2, the difference from Example 1 is that the medicinal part of the caper fruit in Example 2 is to crush the caper fruit and pass through a 80-mesh sieve to a 200-mesh sieve to obtain the caper fruit medicinal part. parts.

Embodiment 3

[0030] Embodiment 3, the difference from Example 1 is that the medicinal part of caper fruit in embodiment 3 is to crush the caper fruit and pass through a 10-mesh sieve to a 30-mesh sieve, and add the sieved caper 6 times to 12 times the weight of citrus fruits in 90% to 95% ethanol aqueous solution, soaked to the heart, heated and refluxed for 1 to 3 times, each extraction for 0.5 hours to 2 hours, filtered, and the above filtrates were combined, Concentrate to a thick paste with a relative density of 1.05 to 1.20 at a relative density of 60°C under the conditions of a temperature of 50°C to 70°C and a vacuum of -0.06Mpa to -0.1Mpa to obtain the medicinal part of the caper fruit.

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PUM

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Abstract

The invention relates to capparis spinosa fruit gel ointment, a production method thereof, and application thereof to antirheumatic medicaments. The capparis spinosa fruit gel ointment comprises a backing layer, a medicament-containing ointment body and a covering layer protective film, wherein the medicament-containing ointment body is prepared from the following raw materials: a medicinal part of the capparis spinosa and a medicinal excipient; a covering material of the covering layer protective film is one of release paper, a plastic film, a polyester, an aluminum foil-polyethylene composite film and hard gauze; and a backing material of the backing layer is one of cotton cloth, non-woven fabric and chemical fiber cloth. The apparis spinosa fruit gel ointment provided by the invention substitutes the apparis spinosa fruit serving as a medicament for the traditional root bark, so the contradiction between the resource utilization of the apparis spinosa medicinal plants and ecological protection is solved. More importantly, the apparis spinosa fruit gel ointment provided by the invention solves the problems of irritability and hypersensitivity caused by the clinical application of the traditional formulation and administration way of the apparis spinosa, and has the characteristics of long action time, high moisture retention, high air permeability, avoidance of the first pass effect of livers, using comfortableness and high compliance of patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a caper fruit gel ointment, a production method thereof and an application of antirheumatic drugs. Background technique [0002] capers Capparis spinosa L. is also known as wild watermelon and mouse melon, and it is called "Polik fruit" in Uighur. It is a plant of the genus Capperiaceae. my country is mainly distributed in Xinjiang, produced in Bole, Wusu, Shawan, Manas, Urumqi, Yining, Hami, Turpan, Toksun, Heshuo, Korla, Aksu, and Shule. It grows in Gobi desert, sandy land, rocky slopes and foothills. The root system of capers is very strong, which has important ecological value in increasing the coverage of desert surface vegetation, conserving water, and preventing surface wind erosion. The national legal medicinal part of capers is the root bark, and the quality standard of the root bark of capers is recorded in "Drug Standards of the Ministry of Health of the People's Re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/185A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61P19/02A61P29/00A61P19/06A61K131/00
Inventor 杨伟俊地力努尔·吐尔逊江马建红刘冲
Owner XINJIANG INST OF MATERIA MEDICA
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