Capparis spinosa fruit gel ointment, production method thereof, and application thereof to antirheumatic medicaments

Abstract

The invention relates to capparis spinosa fruit gel ointment, a production method thereof, and application thereof to antirheumatic medicaments. The capparis spinosa fruit gel ointment comprises a backing layer, a medicament-containing ointment body and a covering layer protective film, wherein the medicament-containing ointment body is prepared from the following raw materials: a medicinal part of the capparis spinosa and a medicinal excipient; a covering material of the covering layer protective film is one of release paper, a plastic film, a polyester, an aluminum foil-polyethylene composite film and hard gauze; and a backing material of the backing layer is one of cotton cloth, non-woven fabric and chemical fiber cloth. The apparis spinosa fruit gel ointment provided by the invention substitutes the apparis spinosa fruit serving as a medicament for the traditional root bark, so the contradiction between the resource utilization of the apparis spinosa medicinal plants and ecological protection is solved. More importantly, the apparis spinosa fruit gel ointment provided by the invention solves the problems of irritability and hypersensitivity caused by the clinical application of the traditional formulation and administration way of the apparis spinosa, and has the characteristics of long action time, high moisture retention, high air permeability, avoidance of the first pass effect of livers, using comfortableness and high compliance of patients.

Description

Technical field

[0001] The invention belongs to the technical field of medicine, and is a caper fruit gel ointment, its production method and application of anti-rheumatic drugs. Background technique

[0002] Capers Capparis spinosa L. is also known as wild watermelon and mouse melon, and "Polyke fruit" in Uighur. It is a plant of the genus Capricinaceae. my country is mainly distributed in Xinjiang, produced in Bole, Wusu, Shawan, Manas, Urumqi, Yining, Hami, Turpan, Toksun, Heshuo, Korla, Aksu and Shule. It grows in the Gobi, sandy land, rocky slopes and foothills of desert areas. The root system of capers is very strong, which has important ecological value in increasing the coverage of desert surface vegetation, conserving water, and preventing surface wind erosion. The national legal medicinal part of capers is the root bark. The quality standards of capers root bark are included in the "Medicine Standards of the Ministry of Health of the People's Republic of China·Uyghur...

Examples

Embodiment 1

[0028] In Example 1, the capers fruit gel ointment includes a backing layer, a medicated ointment and a protective film of the cover layer. The medicated ointment is produced according to the following raw material weight percentages: 10% to 60% capers Medicinal parts and the remaining amount of medicinal excipients; the backing material used in the backing layer is one of cotton cloth, non-woven fabric, and chemical fiber cloth; the covering material used for the protective film of the cover lining layer is anti-sticking One of paper, plastic film, polyester, aluminum foil-polyethylene composite film, and hard gauze.

Embodiment 2

[0029] The difference between Example 2 and Example 1 is that the medicinal part of the capers fruit in Example 2 is that the capers fruit is crushed and passed through a 80-mesh sieve to a 200-mesh sieve to obtain the medicinal capers fruit. Location.

Embodiment 3

[0030] Example 3 is different from Example 1 in that: the medicinal part of the capers fruit in Example 3 is that the capers fruit is crushed and passed through a 10-mesh sieve to a 30-mesh sieve, and the sifted capers are added The citrus fruit is 6 times to 12 times by weight of a 90% to 95% ethanol aqueous solution, soaked until thoroughly, heated and refluxed for extraction 1 to 3 times, each extraction is 0.5 to 2 hours, filtered, and the above-mentioned filtrates are combined, Under the conditions of a temperature of 50°C to 70°C and a vacuum degree of -0.06 Mpa to -0.1Mpa, it is concentrated to a thick paste with a relative density of 1.05 to 1.20 at 60°C to obtain the medicinal part of the capers.

Technical field

[0001] The invention belongs to the technical field of medicine, and is a caper fruit gel ointment, its production method and application of anti-rheumatic drugs. Background technique

[0002] Capers Capparis spinosa L. is also known as wild watermelon and mouse melon, and "Polyke fruit" in Uighur. It is a plant of the genus Capricinaceae. my country is mainly distributed in Xinjiang, produced in Bole, Wusu, Shawan, Manas, Urumqi, Yining, Hami, Turpan, Toksun, Heshuo, Korla, Aksu and Shule. It grows in the Gobi, sandy land, rocky slopes and foothills of desert areas. The root system of capers is very strong, which has important ecological value in increasing the coverage of desert surface vegetation, conserving water, and preventing surface wind erosion. The national legal medicinal part of capers is the root bark. The quality standards of capers root bark are included in the "Medicine Standards of the Ministry of Health of the People's Republic of China·Uyghur...

Examples

Embodiment 1

[0028] In Example 1, the capers fruit gel ointment includes a backing layer, a medicated ointment and a protective film of the cover layer. The medicated ointment is produced according to the following raw material weight percentages: 10% to 60% capers Medicinal parts and the remaining amount of medicinal excipients; the backing material used in the backing layer is one of cotton cloth, non-woven fabric, and chemical fiber cloth; the covering material used for the protective film of the cover lining layer is anti-sticking One of paper, plastic film, polyester, aluminum foil-polyethylene composite film, and hard gauze.

Embodiment 2

[0029] The difference between Example 2 and Example 1 is that the medicinal part of the capers fruit in Example 2 is that the capers fruit is crushed and passed through a 80-mesh sieve to a 200-mesh sieve to obtain the medicinal capers fruit. Location.

Embodiment 3

[0030] Example 3 is different from Example 1 in that: the medicinal part of the capers fruit in Example 3 is that the capers fruit is crushed and passed through a 10-mesh sieve to a 30-mesh sieve, and the sifted capers are added The citrus fruit is 6 times to 12 times by weight of a 90% to 95% ethanol aqueous solution, soaked until thoroughly, heated and refluxed for extraction 1 to 3 times, each extraction is 0.5 to 2 hours, filtered, and the above-mentioned filtrates are combined, Under the conditions of a temperature of 50°C to 70°C and a vacuum degree of -0.06 Mpa to -0.1Mpa, it is concentrated to a thick paste with a relative density of 1.05 to 1.20 at 60°C to obtain the medicinal part of the capers.