3 results about "Isopalmitate" patented technology

The present application relates to the technical field of ophthalmic drugs, in particular to a vitamin C isopalmitate (VC-IP) eye drop for preventing and treating myopia and a preparation method thereof. In view of the problems of large side effects and poor compliance of the existing myopia prevention means, the present application provides an eye preparation taking tetraisopalmitate ascorbate as the main active ingredient, which improves the drug stability and corneal permeability through the liposolubility thereof. The eye drop can effectively inhibit the growth of the eye axis and improve the accommodation lag, and has no irritation, and is suitable for long-term use.

This invention discloses a highly efficient and green synthetic method for ascorbic acid tetraisopalmitate, belonging to the field of organic synthesis technology. The method employs a MOF-confined functionalized catalyst, wherein the catalyst uses acetic acid-etched mesoporous amino-functionalized UiO-66 as a support, and Zn... 2+ Lewis acid centers are modified by coordination with amino groups on the inner wall of the pores, and lipase is covalently immobilized in the mesoporous channels by glutaraldehyde, forming a co-localized synergistic catalytic system. Glycerol is added as a protective agent during catalyst preparation to improve the lipase activity retention rate. Using L-ascorbic acid and methyl 2-hexyldecanoate as raw materials, the target product was synthesized via transesterification in n-heptane solvent at 60-65℃ for 8-16 hours, with a yield of 92.3% and a purity of 99.5%. The catalyst retained 92.6% of its activity even after 10 reuses. This method features mild reaction conditions, avoids the use of highly corrosive reagents, and exhibits good catalyst stability.

This invention discloses a composition, cosmetic, and preparation method with dual whitening and skin-smoothing effects. The composition comprises acetyl glucosamine, ascorbic acid tetraisopalmitate, and adenosine compounds in a mass ratio of (0.1–5):(0.1–10):(0.01–7). It is applied in cosmetics. Compared with existing technologies, the components of this invention work synergistically, resulting in a mild and non-irritating composition with simple and clearly defined components, exhibiting excellent whitening and skin-smoothing functions.