12 results about "Isopalmitate" patented technology

The invention discloses a whitening and spot-fading composition and application thereof, and belongs to the technical field of cosmetics. The whitening and spot-fading composition is prepared from the following components in percentage by mass: 0.1 to 5.0 percent of nicotinamide, 0.0001 to 3.0 percent of tranexamic acid, 0.0001 to 1.0 percent of glycyrrhiza glabra root extract, 0.0001 to 0.4 percent of phenethyl resorcinol, 0.0001 to 2.0 percent of ascorbyl tetraisopalmitate, 0 to 1.0 percent (not including 0) of radix gentianae extract, 0.15 to 4.0 percent of emulsifier, 0.1 to 2.5 percent of antioxidant and the balance of water. By matching with various whitening active ingredients, the comprehensive whitening, brightening and skin improving effects are realized in the aspects of inhibiting melanin generation, blocking melanin transfer, accelerating melanin metabolism and the like; the combination of the specific emulsifier and the thickener can effectively improve the component stability of the composition. The composition is mild in performance, free of irritation to skin and good in market value.

The present application relates to the field of skin care products, and discloses a whitening and anti-aging composition for skin care products and application thereof, and an essence oil and a preparation method thereof. The whitening and anti-aging composition for skin care products contains an active substance combination and a compound essential oil and plant oil combination; the active substance combination contains glabridin, 4-butyl resorcinol, undecylenoyl phenylalanine, natural bisabalol, ascorbic acid tetraisopalmitate and teprenone; the compound essential oil and plant oil combination contains Damascus rose essential oil, magnolia essential oil, frankincense essential oil, Roman chamomile essential oil, carrot seed essential oil, passion fruit seed oil, red wolfberry seed oil, rose fruit oil and sea buckthorn fruit oil. The skin care product prepared from the whitening and anti-aging composition has a more moderate and efficient transdermal absorption rate, and has excellent anti-photoaging effect and whitening and freckle-removing effect.

The present invention relates to a composition comprising sustained release particles of hydroxy pinnacyl retinoate in which the ratio of hydroxy pinnacyl retinoate : methyl methacrylate / ethylene glycol dimethacrylate crosspolymer : ascorbyl tetraisopalmitate or tocopherol is from 0.05 to 3 : 0.1 to 10 : 0.05 to 1 and the use thereof in skin care.

The invention discloses a preparation method of ascorbyl tetraisopalmitate, which is characterized in that L-ascorbic acid and 2-hexylcapraldehyde are used as raw materials, SO4 < 2-> / Fe3O4 (at) TiO2-ZrO2 is used as a main catalyst, GO-Cu-PMA is used as a cocatalyst, and an oxidative esterification reaction is carried out in the presence of an oxidant to prepare the ascorbyl tetraisopalmitate, the mass ratio of the main catalyst to the cocatalyst is (4.5-5.5): 1, and the oxidant is persulfate. The preparation method of ascorbyl tetraisopalmitate provided by the invention has the advantages of mild reaction conditions, high reaction efficiency, simple preparation process, easy recovery of the catalyst, high product yield and purity, easy realization of large-scale production, and very strong industrial application value.

The invention discloses a PI3K-AKT signal channel inhibitor. The PI3K-AKT signal channel inhibitor is prepared from the following components in percentage by mass: 49.0 percent to 49.45 percent of grape seed oil, 49.0 percent to 49.45 percent of pomegranate seed oil, 0.6 percent to 1.0 percent of 4-butylresorcinol and 0.5 percent to 1.0 percent of ascorbyl tetraisopalmitate. The invention also discloses a method for preparing the PI3K-AKT signal channel inhibitor as described above. The invention also discloses an application of the PI3K-AKT signaling pathway inhibitor in preparation of cosmetics for whitening, resisting aging or improving the skin state and a method for evaluating the efficacy of the cosmetics. According to the PI3K-AKT signal channel inhibitor provided by the invention, mRNA expression of PIK3CA and AKT1 genes in a PI3K-AKT signal channel can be effectively inhibited, and regulation and control on the signal channel are realized on a molecular level.

The invention relates to the technical field of cosmetics, in particular to anti-aging and whitening essential oil dew and a preparation method thereof. The anti-aging and whitening essential oil lotion comprises a water phase, an oil phase and a wrapping system, the wrapping system comprises lipidosome and a cyclodextrin inclusion compound; a first active component is encapsulated in the liposome, and the first active component comprises at least one of rosa damascena flower oil, meadowfoam seed oil, raspberry seed oil, tocopherol and ascorbyl tetraisopalmitate; the cyclodextrin inclusion compound comprises a second active component, and the second active component comprises at least one of 4-butylresorcinol, glabridin and acetylchitosamine. According to the invention, the technical bottlenecks of the multi-active-ingredient functional cosmetics in the aspects of stability, transdermal property and efficacy synergy are systematically overcome in principle through an innovative double-synergistic wrapping system and a corresponding preparation method; the invention provides an essential oil lotion product with excellent comprehensive performance and anti-aging and whitening effects and an efficient and reliable preparation method thereof.

The invention belongs to the field of organic synthesis, and particularly discloses a synthesis process of vitamin C tetraisopalmitate, which specifically comprises the following steps: firstly, adding an organic solvent A and an acylation reagent into 2-hexyldecanoic acid, and carrying out acylation reaction to obtain 2-hexyldecanoyl chloride; the preparation method comprises the following steps: dissolving L-ascorbic acid in an organic solvent B, adding tetrabutylammonium bromide, benzyltriethylammonium chloride, an acid-binding agent and 2-hexyldecanoyl chloride, carrying out an esterification reaction in an oxygen-free atmosphere, and purifying after the reaction to obtain the vitamin C tetraisopalmitate. Compared with the traditional synthesis process of the vitamin C tetraisopalmitate, the time for catalyzing the reaction of the L-ascorbic acid and the 2-hexyldecanoyl chloride to generate the vitamin C tetraisopalmitate is less than half of that of the traditional method, the purity of the target product is up to 93% or above, the conversion rate is higher, and the method is more suitable for being popularized to actual production.

The present application relates to the technical field of ophthalmic drugs, in particular to a vitamin C isopalmitate (VC-IP) eye drop for preventing and treating myopia and a preparation method thereof. In view of the problems of large side effects and poor compliance of the existing myopia prevention means, the present application provides an eye preparation taking tetraisopalmitate ascorbate as the main active ingredient, which improves the drug stability and corneal permeability through the liposolubility thereof. The eye drop can effectively inhibit the growth of the eye axis and improve the accommodation lag, and has no irritation, and is suitable for long-term use.

The invention provides a polyquaternium-51 modified high-permeability multi-channel whitening composition, which is prepared from the following raw materials in percentage by mass: 0.001 to 2 percent of tetrahydrocurcumin, 1 to 5 percent of phospholipid, 0.001 to 1 percent of resveratrol, 0.1 to 5 percent of ascorbyl tetraisopalmitate, 0.25 to 5 percent of polysorbate-80, 0.001 to 1 percent of tocopherol, 2 to 10 percent of caprylic / capric triglyceride, 0.001 to 0.1 percent of polyquaternium-51 and the balance of water. The invention relates to an anti-rust agent, which is prepared from the following raw materials in percentage by mass: 30 to 45 percent of polyhydric alcohol, 2 to 10 percent of tranexamic acid, 0.001 to 3 percent of alpha-arbutin and the balance of deionized water, and the sum of the mass percent of all the raw materials is 100 percent. The invention also provides a preparation method of the high-permeability multi-channel whitening composition. The polyquaternium-51 modified high-permeability multi-channel whitening composition provided by the invention has a multi-channel whitening effect and relatively good stability and permeability.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of ascorbyl tetraisopalmitate. The preparation method of ascorbyl tetraisopalmitate provided by the invention comprises the following steps: adding L-ascorbic acid, isopalmitic acid and a catalyst DMAP into a polar aprotic solvent, and uniformly mixing; under the protection of nitrogen, cooling the mixed solution to-5-5 DEG C, adding a condensing agent EDCI in batches, and carrying out condensation reaction at 20-30 DEG C; and after the reaction is finished, adding water, and sequentially carrying out extraction, washing, water removal and concentration to obtain ascorbyl tetraisopalmitate. The preparation method provided by the invention does not need to prepare an acyl chloride compound in advance, is simple in post-treatment, has ideal yield and purity, and is easy to realize industrial production.

This invention discloses a highly efficient and green synthetic method for ascorbic acid tetraisopalmitate, belonging to the field of organic synthesis technology. The method employs a MOF-confined functionalized catalyst, wherein the catalyst uses acetic acid-etched mesoporous amino-functionalized UiO-66 as a support, and Zn... 2+ Lewis acid centers are modified by coordination with amino groups on the inner wall of the pores, and lipase is covalently immobilized in the mesoporous channels by glutaraldehyde, forming a co-localized synergistic catalytic system. Glycerol is added as a protective agent during catalyst preparation to improve the lipase activity retention rate. Using L-ascorbic acid and methyl 2-hexyldecanoate as raw materials, the target product was synthesized via transesterification in n-heptane solvent at 60-65℃ for 8-16 hours, with a yield of 92.3% and a purity of 99.5%. The catalyst retained 92.6% of its activity even after 10 reuses. This method features mild reaction conditions, avoids the use of highly corrosive reagents, and exhibits good catalyst stability.

This invention discloses a composition, cosmetic, and preparation method with dual whitening and skin-smoothing effects. The composition comprises acetyl glucosamine, ascorbic acid tetraisopalmitate, and adenosine compounds in a mass ratio of (0.1–5):(0.1–10):(0.01–7). It is applied in cosmetics. Compared with existing technologies, the components of this invention work synergistically, resulting in a mild and non-irritating composition with simple and clearly defined components, exhibiting excellent whitening and skin-smoothing functions.