Aspirin composition as well as preparation method and application thereof

A technology of aspirin and composition, which is applied in the field of aspirin composition and its preparation, can solve problems such as difficult to realize drugs, and achieve the effect of solving stomach irritation and difficulty swallowing

Inactive Publication Date: 2020-11-03
王天怡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the drug does not dissolve in water or in the mouth, it is difficult to achieve the dissolution of the drug in the intestinal tract, so ordinary enteric-coated preparations cannot achieve this purpose

Method used

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  • Aspirin composition as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] This embodiment provides a kind of aspirin composition, and its preparation method comprises the following steps:

[0051] S1. Aspirin is used as the raw material drug; wherein, 80% of the particle size of the raw material drug can be controlled between 80-100 mesh.

[0052] S2. Add 50g of hydroxypropyl cellulose (HPC-SL) to the mixed solvent of 50g of water and 400g of ethanol while stirring, and keep stirring until the solution is clear, then add 50g of talcum powder and stir to prepare a suspension solution to obtain the first isolation coating solution and set aside.

[0053] S3, placing 1000g of the above-mentioned bulk drug (crude drug in step S1) in a fluidized bed, coating the bulk drug with 550g of the first isolation coating solution, and then drying until the moisture content is lower than 2%, to obtain Material A; wherein, the coating treatment conditions in this step are as follows: material temperature is 32°C, air inlet temperature is 60°C, air outlet te...

Embodiment 2

[0061] This embodiment provides a kind of aspirin composition, and its preparation method comprises the following steps:

[0062] S1. Aspirin is used as the raw material drug; wherein, 80% of the particle size of the raw material drug can be controlled between 80-100 mesh.

[0063] S2, 50g of polyvinylpyrrolidone (K30) was added to 500g of ethanol while stirring, and continued to stir until the solution was clear, then added 50g of talcum powder to prepare a suspension to obtain the first isolation coating solution, spare.

[0064] S3. Put 1000g of the above-mentioned crude drug in a fluidized bed, coat the crude drug with 600g of the first isolation coating solution, and then dry it until the water content is lower than 2%, to obtain material A; wherein, this step The conditions of the coating treatment are as follows: the material temperature is 30°C, the inlet air temperature is 50°C, the outlet air temperature is 25°C, and the air inlet volume is 0.5m 3 / min / kg, the liqu...

Embodiment 3

[0072] This embodiment provides a kind of aspirin composition, and its preparation method comprises the following steps:

[0073] S1. Aspirin is used as the raw material drug; wherein, 80% of the particle size of the raw material drug can be controlled between 80-100 mesh.

[0074] S2. Add 20g of hydroxypropyl methylcellulose into the mixed solvent of 280g of water and 300g of ethanol while stirring, and continue to stir until the solution is clear, then add 50g of silicon dioxide and 50g of talc Powders were mixed to prepare a suspension to obtain the first isolation coating liquid, which was set aside.

[0075] S3. Put 1000g of the above-mentioned crude drug in a fluidized bed, coat the crude drug with 648g of the first isolation coating solution, and then dry it until the water content is lower than 2%, to obtain material A; wherein, this step The conditions of the coating treatment are as follows: the material temperature is 35°C, the air inlet temperature is 65°C, the ai...

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Abstract

The invention is suitable for the technical field of medicines, and provides an aspirin composition as well as a preparation method and application thereof. The aspirin composition comprises aspirin,an enteric coating layer, a first isolation coating layer, a gastric-soluble coating layer and a second isolation coating layer, wherein the enteric coating layer comprises an enteric material which dissolves in intestinal juice and does not dissolve in the stomach; the first isolation coating layer is arranged between the aspirin and the enteric coating layer; the gastric-soluble coating layer comprises a gastric-soluble material which dissolves in the stomach and cannot dissolve in water and intestinal juice; the second isolation coating layer is used for isolating the gastric-soluble coating layer from the enteric coating layer; and the second isolation coating layer comprises an adhesive. According to the aspirin composition provided by the invention, the aspirin is sequentially coatedwith the first isolation coating layer, the enteric coating layer, the second isolation coating layer and the gastric-soluble coating layer, so that medicines cannot dissolve under the conditions ofan oral cavity and gastric juice, and can quickly dissolve under the condition of intestinal tracts; and therefore, an oral formulation suitable for children is prepared, and the problem that the aspirin irritates the stomach is solved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an aspirin composition and a preparation method and application thereof. Background technique [0002] Congenital heart disease is the most common type of congenital malformation, accounting for about 28% of various congenital malformations, accounting for 0.4% to 1% of living babies, which means that there are 15-15% new congenital heart disease patients in my country every year. 200,000. Without timely treatment, about 1 / 3 of the children died of serious complications within 1 year after birth. Most children require surgery to correct the deformity. At present, most children with timely surgical treatment can return to normal like normal people. However, whether it is interventional treatment or surgical treatment, children have a potential risk of blood clots after surgery. Therefore, it is necessary to take aspirin after surgery to prevent the formation of blo...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K9/16A61K9/14A61K47/38A61K47/32A61K47/36A61K47/14A61K47/02A61K47/04A61K47/20A61K47/26A61P7/02
CPCA61K9/143A61K9/145A61K9/146A61K9/1611A61K9/1617A61K9/1623A61K9/1635A61K9/1652A61K31/616A61P7/02
Inventor 王天怡姜海涛
Owner 王天怡
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