Preparation of retinol nano-emulsion with low irritation and high stability

Abstract

The invention provides a retinol nano-emulsion with low irritation and high stability for cosmetics, which comprises the following components in percentage by mass: 5-15% of retinol, 4.1-7.1% of salt-sensitive surfactant composition, 13.4-30% of caprylic / capric triglyceride, 10-22% of glycerol, 2-4% of antioxidant composition and the balance of deionized water. The retinol nano-emulsion disclosed by the invention has the advantages of low skin irritation, good stability, convenience in use and the like.

Description

Technical field: [0001] The invention relates to the technical field of cosmetic functional ingredient carrier systems, and more particularly relates to the preparation of a low-irritation and high-stability retinol nanoemulsion for cosmetics. Background technique: [0002] Retinol has a wide range of biological activities, which can reduce skin wrinkles, promote skin regeneration, and make skin bright and elastic. Therefore, many foreign cosmetics contain retinol, which is used as an anti-wrinkle or skin rejuvenation active ingredient. [0003] However, there are many difficulties in the use of retinol in cosmetics, mainly because the structure of retinol contains more unsaturated double bonds, and its stability to light and heat is poor. Moreover, retinol is more irritating to the skin, so the European Union stipulates that the content of retinol in skin care products should not exceed 0.3%. Retinol is easily oxidized after being heated. After being oxidized, retinol wil...

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Problems solved by technology

[0004] In order to solve this problem, some existing literature discloses the formula technology that retinol is used for cosmetics, such as patent application CN103565676A (the name is a kind of amphiphilic polymer-coated retinoid coated micelles and cosmetic composition ), patent application CN110101611A (named as a vitamin A anhydrous emulsion and its preparation method), patent application CN105939704A (named as lipid microcapsules preferably containing retinoids and compositions containing them, methods of making them and methods thereof) application in dermatology) and patent application CN1185729 (skin care composition containing retinoids and liposomes), although both active substances are encapsulated, the content of active substances is relatively low, and the use process is relatively complicated , which is not conducive to its addition in cosmetic products; moreover, its raw materials and processes are relatively complicated, requiring the use of shell wrapping materials, and even complex processes such as vacuum powder drying, high requirements for production equipment and personnel, high energy consumption, and Not friendly enough to the environment

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