Water-in-oil nano-emulsion and preparation method thereof

A nanoemulsion, water-in-oil technology, applied in the field of biomedicine, can solve problems such as no obvious promotion

Pending Publication Date: 2022-04-12
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, conventional water-in-oil preparations can only improve the absorption of oil-soluble components in the external phase, and have no obvious promoting effect on the water-soluble active components in the internal water phase. The present invention adds sodium hyaluronate with a penetration-promoting effect in the internal phase Composition, the composition itself can be transdermal, and can carry water-soluble active ingredients into the skin to promote absorption

Method used

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  • Water-in-oil nano-emulsion and preparation method thereof
  • Water-in-oil nano-emulsion and preparation method thereof
  • Water-in-oil nano-emulsion and preparation method thereof

Examples

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preparation example Construction

[0048] The present invention also provides the preparation method of above-mentioned nanoemulsion, described preparation method comprises the following steps:

[0049] The emulsifier is dissolved in the liquid oil to form the oil phase,

[0050] dissolving the hyaluronic acid composition in water to form an aqueous phase,

[0051] The oil phase and the water phase are mixed and homogenized at the same temperature to obtain a nanoemulsion.

[0052] Wherein, the step of dissolving the hyaluronic acid composition in water to form an aqueous phase may also include:

[0053] The hyaluronic acid composition and the water-soluble active ingredient are dissolved in water to form an aqueous phase.

[0054] Wherein, the composition and content of the hyaluronic acid composition, water-soluble active ingredients, etc. are as above.

[0055] The present invention also provides cosmetics comprising the above nanoemulsion.

[0056] The present invention also provides the use of the hyal...

Embodiment 1

[0064] (1) 2g of polyglyceryl-3 diisostearate and 8g of PEG40 hydrogenated castor oil are added to 55g of squalane, heated to 80°C to obtain an oil phase, and 0.2g of hyaluronic acid composition (wherein, transparent In the uronic acid composition, the content of medium molecular weight sodium hyaluronate is 30%, the molecular weight is 200-400kDa, the content of acetylated sodium hyaluronate is 25%, the molecular weight is 20-30kDa, and the content of hydrolyzed sodium hyaluronate is 45%, the molecular weight is 3-10kDa) and 3g of γ-aminobutyric acid are dissolved in 31.8g of ultrapure water, heated to 80 ° C to dissolve to obtain the water phase;

[0065] (2) heating the two-phase material to 80°C, mixing and stirring evenly, and homogenizing with a homogenizer to obtain a coarse emulsion;

[0066] (3) Place the obtained coarse emulsion in a high-pressure homogenizer, and homogenize twice for 5 minutes each time to obtain a nanoemulsion.

Embodiment 2-5

[0068] The only difference between Examples 2-5 and Example 1 is the addition of hyaluronic acid composition and ultrapure water. Wherein, the addition amount of hyaluronic acid composition in embodiment 2 is 0.1g, the addition amount of hyaluronic acid composition in embodiment 3 is 0.5g, the addition amount of hyaluronic acid composition in embodiment 4 is 1g, implements The addition amount of the hyaluronic acid composition in Example 5 is 0.005 g, and the specific contents of each component are shown in Table 1.

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Abstract

The present invention provides a water-in-oil nanoemulsion comprising an oil phase, an aqueous phase, and an emulsifier wherein the aqueous phase comprises a hyaluronic acid composition. The hyaluronic acid composition is added into a water-in-oil nano-emulsion formula to serve as an inner phase of the nano-emulsion, a depot effect can be achieved on a corium layer, storage of active ingredients in skin is enhanced, the active ingredients can be conveyed to a deep skin layer with better hydrophilicity by combining the characteristics that the nano-emulsion is small in particle size and easy to permeate, and therefore the skin can be effectively protected. The transdermal absorption effect is synergistically enhanced; meanwhile, the water-in-oil nano-emulsion can wrap water-soluble active ingredients with poor stability, so that the stability is enhanced, and the problem of irritation is solved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a water-in-oil nanoemulsion and a preparation method thereof. Background technique [0002] Nanoemulsion is a transparent or translucent system composed of water phase, oil phase, surfactant and co-surfactant. Compared with traditional emulsions, most nanoemulsions can effectively prevent the occurrence of unstable processes such as stratification, sedimentation, and aggregation, which makes nanoemulsions widely used in petroleum, food, and cosmetics. [0003] In the practical application of skin care products, active ingredients must penetrate into specific skin sites to be effective. The transdermal ability of active substances is related to the molecular weight. Generally, ingredients with a molecular weight greater than 500 are not easy to penetrate into the skin. Nano-emulsions, microemulsions, liposomes and other nano-preparations can be used to promote the transderm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/92A61K8/06A61K8/31A61K8/37A61K8/44A61K8/46A61K8/49A61K8/60A61K8/64A61K8/65A61K8/67A61K8/58A61Q19/00A61Q19/02A61Q19/08
Inventor 任姝静王玉玲王志华吴越鲍玉刘文文郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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