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Acne-removing ointment and preparation method thereof

An ointment and acne-removing technology, applied in the directions of ointment delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of high propylene glycol content, adverse reactions, desquamation, etc., and achieve high compliance, high cure rate, The effect of restoring fineness

Active Publication Date: 2020-11-20
谢志辉生物医药研究院(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this azelaic acid gel is an oil-free formulation relative to the cream, it can dissolve azelaic acid well, but due to the high content of propylene glycol, there are certain adverse reactions, and the adverse reactions recorded in the examples are mainly For burning pain, itching, erythema, edema, dryness, scaling

Method used

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  • Acne-removing ointment and preparation method thereof
  • Acne-removing ointment and preparation method thereof
  • Acne-removing ointment and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1～5

[0043] Embodiments 1-5 A kind of acne-removing ointment and its preparation method

[0044] The weight percentage content of acne-removing ointment formula is shown in the following table 1 in the embodiment 1~5:

[0045] Acne-removing ointment formula in table 1 embodiment 1~5

[0046]

[0047] The preparation method of acne-removing ointment in embodiment 1~5 comprises the following steps:

[0048] S1. Uniformly disperse azelaic acid in polyol, stir and heat to 85°C to obtain solution A;

[0049] S2. Evenly disperse the emulsifier in solution A, stir and heat to 85°C to obtain solution B;

[0050] S3. Add fatty alcohol to solution B while stirring to obtain solution C;

[0051] S4. Add polydimethylsiloxane and menthol to solution C, stir evenly, and then cool to room temperature to obtain an acne-removing ointment.

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Abstract

The invention belongs to the technical field of skin medicines, and particularly relates to acne-removing ointment and a preparation method thereof. The acne-removing ointment is prepared from the following components in percentage by weight: 5 to 20 percent of azelaic acid, 0.1 to 1 percent of menthol, 15 to 25 percent of fatty alcohol, 50 to 70 percent of polyhydric alcohol, 2 to 10 percent of emulsifier and 0.1 to 2 percent of polydimethylsiloxane. According to the acne-removing ointment disclosed by the invention, azelaic acid can exist in a formula in a dissolved state, and effective components can permeate into skin more easily, so that the treatment effect of acne is improved; meanwhile, the emulsifier and the fatty alcohol are added, so that azelaic acid dissolved by the polyhydricalcohol is slowly released, greasy feeling and adverse reaction caused by high-content polyhydric alcohol are relieved, and the low-temperature stability of the ointment is improved.

Description

technical field [0001] The invention relates to the technical field of skin medicines, in particular to an acne-removing ointment and a preparation method thereof. Background technique [0002] Acne (acne) is a chronic inflammatory skin disease of the pilosebaceous unit. The clinical symptoms are mainly pleomorphic skin lesions such as facial acne, papules, pustules, and nodules. Acne itself or the scars left will affect the face. Severe cases can cause hyperpigmentation, persistent erythema, depressed or hypertrophic scars, etc. Acne mainly occurs in adolescents and has a great psychological and social impact on adolescents. [0003] Rosacea, also known as rosacea, is a chronic inflammatory skin disease that takes the middle of the face as the main site of disease and involves the pilosebaceous glands and blood vessels. In the early clinical stage, seborrhea and erythema may appear, and telangiectasias gradually appear, showing dendrites. In the middle stage, acne-like an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/191A61K47/34A61K47/10A61K9/06A61P17/10A61K31/045
CPCA61K31/191A61K31/045A61K47/34A61K47/10A61K9/06A61K9/0014A61P17/10A61K2300/00
Inventor 谢志辉吴超锐
Owner 谢志辉生物医药研究院(广州)有限公司
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