Hyaluronic acid multiple emulsion with stability improving effect, preparation method and application thereof

A technology of hyaluronic acid and multiple emulsions, which is applied in the direction of dressing preparations, skin care preparations, cosmetic preparations, etc., can solve problems such as delamination, emulsion rupture and coalescence, and application limitations, so as to improve stability and promote Absorption, irritating effect

Pending Publication Date: 2022-04-08
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, it is precisely because of the special "two-film three-phase" structure of multiple emulsions that the multiphase interface of multiple emulsions has a high interfacial energy, which makes the emulsions prone to rupture and coalescence, and separation will occur after several weeks of storage. Layer phenomenon, so its application is also limited to a certain extent

Method used

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  • Hyaluronic acid multiple emulsion with stability improving effect, preparation method and application thereof
  • Hyaluronic acid multiple emulsion with stability improving effect, preparation method and application thereof
  • Hyaluronic acid multiple emulsion with stability improving effect, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] (1) Start the constant temperature water bath, maintain the temperature at 40-50°C, take an appropriate amount of deionized water in beaker A, and preheat in the constant temperature water bath to obtain phase A.

[0108] (2) Weigh squalane, polyglycerol-2 oleate and retinol in beaker B, then stir evenly, place in a constant temperature water bath and preheat to obtain phase B.

[0109] (3) Add phase A to phase B to prepare W / O colostrum.

[0110] (4) Weigh deionized water, hyaluronic acid composition and polyglycerol-10 stearate in beaker C and mix to obtain C phase, then add W / O colostrum into C phase, stir to obtain W / O O / W multiple emulsion, wherein, the content of each component is shown in Table 1, in terms of mass percentage in hyaluronic acid, sodium hyaluronate with a molecular weight of 150kDa accounts for 25%, and acetyl acetate with a molecular weight of 10kDa accounts for 25%. Hydrolyzed sodium hyaluronate accounts for 40%, and hydrolyzed sodium hyaluronat...

Embodiment 2-13

[0112] Example 2-Example 13 Prepare multiple emulsions according to the method of Example 1, wherein, the content of each component is shown in Table 1, in terms of the mass percentage of hyaluronic acid, the molecular weight is 150kDa transparent Sodium hyaluronate accounted for 25%, acetylated sodium hyaluronate with a molecular weight of 10 kDa accounted for 40%, and hydrolyzed sodium hyaluronate with a molecular weight of 15 kDa accounted for 35%.

Embodiment 14

[0114] Example 14 According to the method of Example 1 to prepare multiple emulsions, each component is the same as Example 1, and the difference lies in the content of various sodium hyaluronates in the hyaluronic acid composition. In terms of mass percentage, the sodium hyaluronate with a molecular weight of 150kDa accounts for 25%, the acetylated sodium hyaluronate with a molecular weight of 10kDa accounts for 20%, and the hydrolyzed sodium hyaluronate with a molecular weight of 15kDa accounts for 55%.

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Abstract

The invention discloses a multiple emulsion containing hyaluronic acid as well as a preparation method and application thereof. The multiple emulsion comprises an oil phase, a W/O type emulsifier, an O/W type emulsifier and a hyaluronic acid composition. The hyaluronic acid composition is added into the multiple emulsion to serve as an outer water phase of the W/O/W type emulsion, the stability of the multiple emulsion can be improved by adding the hyaluronic acid composition, and absorption of active ingredients in the multiple emulsion is promoted; the irritant active ingredients can be wrapped in the inner phase of the multiple emulsions, and the problem of irritation of cosmetics can be effectively solved by adding the hyaluronic acid composition.

Description

technical field [0001] The invention relates to the technical field of hyaluronic acid, in particular to a hyaluronic acid multiple emulsion capable of improving stability, a preparation method and application thereof. Background technique [0002] There are only two types of traditional emulsions, O / W type and W / O type. W / O type emulsion has a bright appearance, good moisturizing and emollient effect, but it is easy to stick when applied, the skin feels poor, and it is not easy to clean; while O / W type emulsion has good spreadability and refreshing effect. Skin feel, but the moisturizing effect and emollient effect are not as good as W / O emulsion. [0003] Multiple emulsions are multi-layer emulsions formed by dispersing one emulsion in another continuous phase. Generally, they are highly dispersed and multi-phase systems with different particle sizes. There are many types, such as W / O / W and O / The two types of W / O are the most common. Structurally, multiple emulsions ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/67A61K8/06A61Q19/00
Inventor 王志华王玉玲任姝静刘文文
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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