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A pyrrole dicarboxylic acid compound in purslane and its extraction and separation method and use

A technology of pyrrole dicarboxylic acid and separation method, which is applied in the field of pyrrole dicarboxylic acid compounds and their extraction and separation, can solve the problems of low structural novelty and the like, and achieves the effects of environmental protection process method, simple and fast operation method

Active Publication Date: 2022-05-13
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • A pyrrole dicarboxylic acid compound in purslane and its extraction and separation method and use
  • A pyrrole dicarboxylic acid compound in purslane and its extraction and separation method and use
  • A pyrrole dicarboxylic acid compound in purslane and its extraction and separation method and use

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Embodiment 1

[0029] The invention provides a kind of pyrrole dicarboxylic acid compound, molecular formula is C 7 h 8 N 2 o 5 , named 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid, chemical structure formula is.

[0030]

[0031] The pyrrole dicarboxylic acid compound is named 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid according to the structure, and Table 1 shows the NMR data of the pyrrole dicarboxylic acid compound: 1 H-NMR with 13 C-NMR in DMSO.

[0032] Table 1 NMR data of pyrrole dicarboxylic acid compound 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid of the present invention

[0033] Numbering δC type δH,mult(J in Hz) 1 NH 2 124.81 C 3 147.74 C 4 113.95 CH 6.66(1H,d,3.30) 5 115.25 CH 6.78(1H,d,3.84) 6 161.60 C 7 N 8 160.35 C 9 O 10 51.36 CH 3

3.77(3H)

[0034] The invention discloses a structure identification and deduction of a pyrrole...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to pyrrole dicarboxylic acid compounds extracted, separated and identified from purslane and an extraction and separation method thereof. Described pyrrole dicarboxylic acid compound, molecular formula is C 7 h 8 N 2 o 5 , named 3‑(carboxy(methoxy)amino)‑1H‑pyrrole‑2‑carboxylic acid. Also provided is an extraction and separation method for the above-mentioned pyrrole dicarboxylic acid compound, which is prepared by decocting in water, ethyl acetate extraction, silica gel column chromatography, ODS medium pressure column, Sephadex LH‑20 purification, and liquid phase separation. Its structure adopts 1 H NMR, 13 C NMR and two-dimensional NMR spectral analysis method identified as a new pyrrole dicarboxylic acid compound. The compound has potential anti-inflammatory and anti-cholinesterase activities, and provides a preparation method to provide a lead and a theoretical basis for the development of new drugs and new components.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a pyrrole dicarboxylic acid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane likes fertile soil, is resistant to drought and waterlogging, has strong vitality, is widely distributed, and is rich in resources, and it is more common in Northeast my country. Purslane can be used as both medicine and food, and it is one of the wild plants with the same origin of medicine and food designated by the Ministry of Health of my country. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects of clearing away heat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D207/34A61P29/00A61P25/28A61P11/06A61P27/02
CPCC07D207/34A61P29/00A61P25/28A61P11/06A61P27/02
Inventor 英锡相崔馨予张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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