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Alkaloid oleraurea in purslane and its extraction and separation method

A separation method and alkaloid technology, which are applied in food extraction, chemical instruments and methods, and food ingredients containing natural extracts, etc., can solve the problems of low structural novelty, and achieve the effects of environmental protection process method, simple and fast operation method.

Active Publication Date: 2020-04-21
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Alkaloid oleraurea in purslane and its extraction and separation method
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  • Alkaloid oleraurea in purslane and its extraction and separation method

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Embodiment 1

[0031] The invention provides an alkaloid compound, the molecular formula is C 19 H 34 N 2 O 3 , Named oleraurea. The chemical structural formula is:

[0032]

[0033] The alkaloid compound is named oleraurea according to the structure. Table 1 shows the NMR data of the alkaloid compound: 1 H-NMR and 13 C-NMR in deuterated DMSO.

[0034] Table 1: NMR data of the alkaloid compound of the present invention

[0035]

[0036]

[0037] Refer to Figure 1-10 , The structure identification and derivation of the alkaloid compound of the present invention.

[0038] Oleraurea: white powder, easily soluble in methanol, insoluble and slightly soluble in water. After spotting the sample on the silica gel plate, the spots of the bromocresol blue test solution sprayed blue, indicating that the compound contains carboxyl groups. UV(MeOH)λ max :226, 290nm, IRν N-H 3442cm -1 , Ν CH 2932cm -1 , 2861cm -1 ν C=O 1650, 1606cm -1 ,δ CH 1355cm -1 . HRESI(+)TOFMS gives m / z: 339.2611[M+H] + The quasi-...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to an alkaloid compound extracted, separated and identified from purslane and an extraction and separation method thereof. The alkaloid compound has a molecular formula of C19H34N2O3 and is named oleraurea. The invention also provides an extraction and separation method of the novel compound, which sequentially adopts 50-percent ethanol reflux extraction, polyamide column chromatography, silica gel column chromatography, an ODS medium pressure column, and Sephadex LH-20 to successfully extract and separate a novel alkaloid compound. The novel compound has anti-cholinesterase and anti-inflammatory effects, and the novel compound and a salt or a derivative thereof can be used as asynthetic precursor for other compounds and a raw material for new drug development and pharmacological activity research, and can be used for preparing anti-cholinesterase and anti-inflammatory drugsor health products.

Description

Technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to alkaloid compounds extracted, separated and identified from Portulaca medicinal materials and methods for extraction and separation thereof. Background technique [0002] Portulaca oleracea (Portulaca oleracea L.), also known as longevity vegetable, horse amaranth, five elements grass, is an annual fleshy herb of the Portulaceae family. Purslane is tolerant of drought and flood, and is tolerant to light and shade. It is widely distributed and rich in resources. Most of them are wild and few are cultivated. They are one of 78 wild plants with the same medicine and food as stipulated by the Ministry of Health. They were included in the recipes of the 2008 Beijing Olympic Games. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" contains the dry above-ground part of Portulaca oleracea as medicine. It has the functions of cl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C277/08C07C279/14A61P29/00A23L33/105
CPCA23L33/105A23V2002/00C07C279/14A23V2200/30A23V2250/21A23V2300/14
Inventor 英锡相迪迪尔·史蒂恩修芬英哲铭张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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