Preparation method and application of purely natural product for preventing and treating insomnia

A pure natural, production method technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve problems such as limited resources of Cordyceps sinensis, failure to meet market demand, and harsh growth environment requirements for Cordyceps sinensis

Inactive Publication Date: 2020-06-09
贵州贵安精准医学股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the harsh requirements of Cordyceps sinensis on the growth environment, the resources of Cordyceps sinensis are extremely limited and cannot meet the increasing market demand

Method used

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  • Preparation method and application of purely natural product for preventing and treating insomnia
  • Preparation method and application of purely natural product for preventing and treating insomnia
  • Preparation method and application of purely natural product for preventing and treating insomnia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of Cordyceps Adenosine and Cordyceps Polysaccharide Extract

[0029] (a) Pretreatment: take the dried fruiting body of Cordyceps militaris as raw material, and carry out ultra-low temperature pulverization treatment to obtain superfine powder of Cordyceps militaris.

[0030] (b) Water extraction: add a certain amount of extraction solvent to the superfine powder, and perform the extraction operation under a certain temperature condition; combine the extracts and concentrate. The extraction solvent in step (b) is purified water;

[0031] (c) Ethanol extraction: the concentrate obtained in step (b) is dispersed with an appropriate amount of water, an extraction solvent is added, and the extraction operation is performed at an extraction temperature of 0-4°C, and the impregnated extract is centrifuged and collected The supernatant after centrifugation was processed, and the collected supernatant was concentrated and dried by rotary evaporation. The...

Embodiment 2

[0033] Embodiment 2: product making

[0034] This product is made of Cordyceps adenosine and Cordyceps polysaccharide as raw materials, the mass proportion of Cordyceps adenosine is 55%, and the mass proportion of Cordyceps polysaccharide is 45%. According to the requirements of different dosage forms in the later stage, Cordyceps adenosine and Cordyceps polysaccharide can be further processed into tablets, capsules, granules, granules and other series of products in any proportion together with other dosage form excipients.

Embodiment 3

[0035] Embodiment 3: The acute toxicity experiment of this product (pentadenosine) to mice

[0036] Examine the acute toxicity of five types of adenosine samples.

[0037] 【Drugs and Reagents】

[0038] Tested sample: five types of adenosine samples (batch number: 20131121, ingredients: 55% Cordyceps adenosine, 45% Cordyceps polysaccharide, storage method: 4°C refrigeration, preparation method: mix 55% Cordyceps adenosine and 45% Cordyceps polysaccharide after soluble in pure water)

[0039] 【Experimental animals】

[0040]KM mice (18-25g, half male and half female) (animal license number: SCXK (Beijing) 2012-0001, certificate number: 11400700020779), animal sources (Experimental Animal Center, Academy of Military Medical Sciences of the Chinese People's Liberation Army, SCXK (army) 2012-0004), feed source (Experimental Animal Center, Academy of Military Medical Sciences of the Chinese People's Liberation Army, SCXK (Army) 2007-001), feeding environment: normal grade, room te...

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PUM

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Abstract

The invention establishes a novel method for preparing a product by taking cordyceps militaris as a raw material and extracting and separating anti-insomnia medicinal components from the cordyceps militaris according to a certain formula process. Experimental results of toxicity, medicinal effect and the like show that the product is free of toxicity, and has effects of improving the sleep effectof a human body and improving sleep quality. As effective components and auxiliary materials are both extracted from cordyceps militaris, the product has no toxic or side effect on human bodies and does not casue tolerance. According to the characteristics of the cordyceps militaris, the product can improve functional quality of human bodies while preventing and treating sleep problems, and can besafely used for regulating sleep of a human body and treating insomnia.

Description

technical field [0001] The invention relates to the technical field of processing and extracting Cordyceps militaris products, in particular to a preparation method and application of a pure natural product for preventing and treating insomnia. Background technique [0002] Insomnia is a common disease, frequently-occurring disease, and has had a strong impact on people's life, work and physical and mental health. The incidence of serious accidents and traumas in long-term insomniacs is significantly higher than that in normal sleepers. However, traditional anti-insomnia drugs have large side effects and strong dependence, so developing healthy foods or medicines for the prevention and treatment of insomnia has become a new problem of scientific research. [0003] It has been reported in the literature that many natural medicines such as the extracts of zygomatic plants, jujube roots, raw jujube kernels, fried jujube kernels, albizia juniper, snake vine fruit, cordyceps sin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P25/20
CPCA61K36/068A61K2236/331A61K2236/333A61K2236/55A61P25/20
Inventor 曹军陈玉皎杜思邈聂开美耿书莉
Owner 贵州贵安精准医学股份有限公司
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