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Composition capable of calming mind and assisting sleep, preparation method therefor and application of composition

A technology for calming the heart and assisting sleep and composition, applied in the directions of drug combination, food science, pharmaceutical formula, etc., can solve the problem of secretion function affecting the balance of the body, etc., and achieve the effect of shortening sleep latency, using natural materials, and improving the incidence of sleep.

Inactive Publication Date: 2021-07-16
青岛海生洋润生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the homogenization of sleep-improving health foods on the market is serious, and most of them use melatonin as the main raw material. However, the effect of melatonin on improving sleep needs further verification. Melanin can inhibit the body's own secretion function and affect the balance of the body

Method used

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  • Composition capable of calming mind and assisting sleep, preparation method therefor and application of composition
  • Composition capable of calming mind and assisting sleep, preparation method therefor and application of composition
  • Composition capable of calming mind and assisting sleep, preparation method therefor and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of the composition for calming the mind and helping sleep comprises the following steps:

[0026] (1) Weigh 20g of oyster (raw), 15g of jujube seed, 5g of lily, 5g of poria, 5g of red date, 5g of rose, 5g of malt (fried), 5g of hawthorn, 5g of licorice, and 3g of tangerine peel, and crush various raw materials into 20 -80-mesh coarse powder, heated and refluxed with 10 times the weight of water to extract 3 times, filtered, combined the extracts obtained three times, concentrated under reduced pressure at 70°C, and spray-dried to obtain solid powder 1; wherein, the oyster (raw) was not Calcined raw oyster shells.

[0027] (2) Weigh 10g of fresh oyster meat and 10g of mussels, homogenate, add 1 times the weight of water, adjust the pH to 2.5, add 0.5% (v / v) pepsin, and adjust the pH to 10. Then add 0.5% (v / v) alkaline protease, hydrolyze for 1.5h, boil at 100°C for 10min, centrifuge after cooling, dry the supernatant under reduced pressure at 70°C, and s...

Embodiment 2

[0031] In order to observe the effect of the Ningxin Aiding Sleep Composition prepared in Example 1 on the sleep of mice, this experiment was carried out through direct sleep test, prolongation of pentobarbital sodium sleep time test, pentobarbital sodium subthreshold dose hypnosis test, barbital Sodium sleep latency test to observe its effect on improving sleep. If two of the three tests of prolonging pentobarbital sodium sleep time test, pentobarbital sodium subthreshold dose hypnosis test and barbital sodium sleep latency test are positive, and there is no obvious direct sleep effect, it can be judged that the combination of calming the mind and helping sleep It has the effect of improving sleep function.

[0032] 1. Experimental samples and experimental methods

[0033] Animal: Kunming mouse, male. Breeding in PVC boxes, 5 birds per box, room temperature 20-26°C, daily temperature difference ≤4°C, relative humidity 40-70%, day and night light and dark alternation time 12...

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Abstract

The invention discloses a composition capable of calming mind and assisting sleep, a preparation method therefor and application of the composition. The composition capable of calming the mind and assisting the sleep comprises raw oyster shells, wild jujube seeds, lily bulbs, poria cocos, dried red dates, roses, fried malt, fructus crataegi, radix glycyrrhizae, dried tangerine peels, fresh oyster meat, mussels and gamma-aminobutyric acid. The composition capable of calming the mind and assisting the sleep is natural in ingredient, scientific in proportioning ratio and free of toxic or side effects; and confirmed by animal in-vivo experiments, the composition can be used for obviously increasing sleep incidence rate of sodium pentobarbital in a sub-threshold dose and shortening the sleep latency period of sodium barbital, plays a role in improving the sleep, and then, can be applied to preparation of foods or healthcare products for improving the sleep.

Description

technical field [0001] The invention belongs to the field of food, and in particular relates to a composition for calming the mind and promoting sleep, a preparation method and application thereof. Background technique [0002] With the change of social environment, people's work and life pressure are increasing day by day, and the number of people with insomnia is gradually increasing. Insomnia, as a common and frequently-occurring disease in the current society, has had a serious impact on people's health and quality of life. The main manifestations of insomnia are: difficulty in falling asleep, easy to wake up from light sleep, difficulty falling asleep after waking up, dreaminess, often accompanied by daytime lassitude, weakness of limbs, unresponsiveness, low work efficiency, headache, memory loss and other symptoms. According to surveys and studies, 1 / 3 of adults in my country suffer from insomnia, and 1 / 3 of them have reached the level of severe insomnia. [0003] A...

Claims

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Application Information

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IPC IPC(8): A23L33/10A23L33/175A23L17/40A61K36/8998A61P25/20A61K35/618A61K31/197
CPCA23L33/10A23L33/175A23L17/40A61K35/618A61K36/725A61K36/8967A61K36/076A61K36/738A61K36/8998A61K36/734A61K36/484A61K36/752A61K31/197A61P25/20A23V2002/00
Inventor 杨文哲杨雪张鹏管谊黎华王国瑞马晓青
Owner 青岛海生洋润生物科技有限公司
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