16 results about "Circadian process" patented technology

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl)oxy)acetamidolbenzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMALl interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The application discloses a method and system for monitoring light and sleep and improving sleep and circadian rhythm, and aims at the problems of single application scene and function, lagging theory and lack of deep analysis in existing sleep intervention methods, adopts sleep monitoring and light improvement services based on the non-visual effect theory of light, forms the cyclic regulation and feedback of sleep and light monitoring, analysis and evaluation and sleep intervention guidance, guides users to select appropriate lighting lamps, light exposure time and total amount, utilizes light which is strong synchronization and non-contact to improve the circadian rhythm and sleep of personnel, and thus the system can be suitable for the sleep habits of each user and keep a stable circadian rhythm.

The present invention relates to a bracelet and system for regulating the circadian rhythm, the bracelet comprising an electronic control module integrated into an enclosing body, said module being connected to a core in direct contact with the user's skin. The control module comprises a communication module connected to a microcontroller including a digital timer, the communication module and the microcontroller being connected to an electrical power source. The core comprises an activation mechanism including an actuator, connected to the microcontroller of the control module that acts on a melatonin microsphere reservoir, which is in contact with distribution microchannels that are connected to biodegradable microneedles in contact with the user's skin and which apply the melatonin transdermally. Said bracelet is integrated into a system.

The present invention provides a kind of nucleoside analogue compounds, and a composition comprising the compound and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via the compound or the composition.

This invention relates to a method and system for optimizing meal replacement intake time based on circadian rhythms, belonging to the field of nutrition management technology. It includes: collecting basic user information, sleep time, and wake-up time; determining a sleep-wake cycle based on sleep and wake-up times; retrieving user age and gender based on the basic information and dividing the sleep-wake cycle into physiological time periods; retrieving health goals and physical fitness parameters based on the basic information to determine the types of meal replacement foods; determining the initial time for meal replacement intake based on physiological time periods and selecting recommended food types; determining a type-based intake adjustment value based on the recommended food types; adjusting the initial time for meal replacement intake based on the type-based intake adjustment value to obtain a recommended meal replacement intake time and outputting it. This invention improves the efficiency of users in achieving their health goals during nutrition management.

A method and apparatus for light intervention to enhance hypoxia resistance, as well as related equipment, are disclosed. The method includes: acquiring first user information characterizing a user's photosensitivity and second user information characterizing the user's circadian rhythm state at their original geographical location; acquiring light dose conditions for light intervention based on the first user information; acquiring time conditions for light intervention based on the second user information; and obtaining light intervention conditions for performing the light intervention based on the light dose conditions and time conditions. Since photosensitivity affects the influence of light dose on circadian rhythms, and circadian rhythm state can improve the fit between time conditions and circadian rhythm state, combining the first and second user information is beneficial to improving the accuracy of light intervention conditions. Furthermore, regulating the human body's circadian rhythm through light intervention enhances the body's resistance to hypoxia, thus improving the economy, safety, and simplicity of enhancing hypoxia resistance.

Certain aspects of the disclosure provide techniques for personalized chronotherapy. An example method includes obtaining sensor data associated with one or more sensors; determining a circadian rhythm based on the sensor data; determining a control schedule, for a device configured to deliver a therapeutic, based on the circadian rhythm and pharmacological data associated with the therapeutic; and controlling the device in accordance with the control schedule.

This invention relates to the fields of digital healthcare and sleep health management technology, and particularly to an insomnia screening and dynamic management system and method. The system includes modules for data acquisition, verification, feature calculation, and strategy generation. The data acquisition module simultaneously acquires subjective, objective, and environmental data streams; the data verification module calculates confidence levels using the coupling characteristics of temperature and heart rate, identifies non-physiological interferences to clean the data; the feature calculation module calculates a sleep perception deviation index to quantify subjective and objective differences, constructs a cumulative sleep pressure model, and integrates body temperature and heart rate characteristics to locate individual biological time; the strategy generation module distinguishes between contradictory and physiological insomnia based on the deviation index to select intervention paths, and remaps the treatment recommendation time to an execution time adapted to the individual's circadian rhythm. This invention utilizes signal coupling verification to ensure data quality, accurately classifies insomnia through the perception deviation index, and achieves dynamic intervention adapted to the individual's circadian rhythm based on biological time mapping.

Provided are an electronic device and a control method therefor. The electronic device comprises: a communication interface; a memory for storing instructions; and at least one processor. The instructions, when collectively or individually executed by the at least one processor, cause the electronic device to: acquire, by using a signal received by means of the communication interface, information about a time when the electronic device is located indoors and information about a time when the electronic device is located outdoors; acquire information about indoor light acquired by a user using the electronic device during the time when the electronic device is located indoors; acquire information about outdoor light acquired by the user during the time when the electronic device is located outdoors; and acquire information about a circadian rhythm of the user on the basis of the information about the indoor light and the information about the outdoor light.

The application relates to the cosmetic technical field, and particularly discloses a composition for micro-ecological balance and circadian rhythm repair and lightening and application. The composition for micro-ecological balance and circadian rhythm repair and lightening comprises the following components in mass percentage: glycyrrhiza glabra root extract 0.001%-1%, olea europaea leaf extract 0.1%-5%, hydraena elongata extract 0.1%-2%, gentiana rigescens 0.5%-3%, inulin 0.1%-5%, tripeptide-3 0.001%-0.01%, jasminum nudiflorum extract 0.5%-2%, and the balance is water. The composition has the advantages of systematically solving multiple problems such as skin redness, dullness and rhythm disorder.

The present invention provides agents and other devices that can advance the phase of the circadian rhythm. [Solution] The body clock regulator contains bergamot oil, geranium oil, and cedarwood. It contains at least one of Virginia oil, citral, and β-caryophyllene. It contains an active ingredient that advances the phase of the expression rhythm of clock genes.

This invention relates to the field of intelligent sleep aid technology, and more particularly to a circadian rhythm lamp and its control method, comprising: selecting a first time zone from a time zone database; acquiring light cycle data corresponding to the first time zone, wherein the light cycle data includes light intensity and sunrise and sunset times, and is divided into time periods according to Greenwich Mean Time (GMT) of sunrise and sunset, wherein one day constitutes one light cycle; determining a set light intensity and a set color temperature based on the light intensity and time period corresponding to the first time zone; and controlling the circadian rhythm lamp to adjust the light intensity based on the set light intensity and set color temperature. This invention can improve the user's sleep quality by selecting a specific time zone and combining it with the light environment data of that time zone for light adjustment.

The application provides a circadian rhythm lighting regulation method and system for the elderly, obtains a daytime blue light ERI cumulative value of a target object; outputs a corresponding first predicted night waking number through a preset CART decision tree, and then corrects the first predicted night waking number based on a night waking number of a second historical day to obtain a second predicted night waking number; obtains a blue light ERI quota at each night waking time of the day based on the daytime blue light ERI cumulative value and the second predicted night waking number; when receiving a night waking trigger information of the target object, obtains a corresponding real-time blue light ERI cumulative value based on a blue light power, then compares the real-time ERI cumulative value with the blue light ERI quota, and finally adjusts the blue light power of a lighting device based on the comparison result. The scheme can not only accurately match the circadian rhythm protection needs of the elderly, but also has strong universality and practical application value.

A method for detecting a circadian rhythm of a user, which includes acquiring measurement data indicating the user's sleep time and determining a user's sleep-wake rhythm of the user based on the measurement data; determining a first phase value based on the sleep-wake rhythm; acquiring skin temperature measurement data for at least one 24-hour measurement period, fitting the skin temperature measurement data to a cosine waveform, and performing evaluation of a quality of the fitting and, if the quality is above a threshold, determining a second phase value on the basis of the fitting; if the quality of the fitting is above the threshold, determining a circadian phase of the user on the basis of a combination of the first phase value and the second phase value; if the quality of the fitting is below the threshold, determining a circadian phase of the user based on the first phase value without the second phase value; and outputting the computed circadian phase or a parameter derivative of the computed circadian phase via an interface to the user.

The application discloses a circadian rhythm lighting controller based on a radio clock, an LED driving module and a lighting system with the same, and the lighting controller comprises a radio clock module receiving time coding information in the form of low-frequency radio waves, a storage device storing lighting parameters related to the time information, an MCU module and a dimming controller; the MCU module receives a timing signal sent by the radio clock module and decodes the current time information; the storage device is accessed to find the lighting parameters matched with the current time; then the lighting instructions are obtained or converted; the dimming controller generates corresponding control signals according to the lighting instructions and sends the control signals to the driving circuit of the lighting load. The radio clock module directly receives the standard time coding signal emitted by the national time service station, and the time error can be controlled within milliseconds, so that an absolute accurate and never-drifting time source is provided for the circadian rhythm lighting.

This invention discloses the application of *Enterobacter holmieae* in the synthesis of dihydroouabain, belonging to the field of microbial technology. The dihydroouabain synthesized by *Enterobacter holmieae* in this invention, due to its unique biological characteristics, has broad application prospects in cardiovascular disease treatment, neuroscience research, energy metabolism, and circadian rhythm regulation. The *Enterobacter holmieae* strain described in this invention is preserved under the name *Enterobacter holmieae*. Enterobacter hormaechei Deposited at Guangdong Provincial Center for Microbial Culture Collection, located at 5th Floor, Building 59, No. 100 Xianlie Middle Road, Guangzhou; Deposit date: April 16, 2026; Accession number: GDMCC No:68091.