173 results about "Circadian process" patented technology

A Circadian Rhythm Monitoring and Regulation (CMR) system and method that includes: a novel non-obtrusive wearable system for increasing the health and productivity of warfighters or other individuals that are disrupted by excessive, abnormal shifts in work or flights across multiple time zones. The CMR system is based on advanced sensor and software technology and models of human circadian system phototransduction and a circadian stimulator oscillator developed by applicants. It measures circadian misalignment and provides lighting suggestions for circadian rhythm maintenance and realignment.

In various examples, circadian rhythm-based data augmentation for drowsiness detection systems and applications are provided. Embodiments described herein may produce an estimated circadian rhythm for a test subject and / or vehicle driver or other machine operator or occupant, and use the pattern of that circadian rhythm to correct, confirm, calibrate, or otherwise augment drowsiness assessments derived from video image data. The position of a person in the context of their process C circadian cycle may be used as indication of their level of drowsiness. An estimated process C circadian cycle may be used to generate more accurate ground truth training data for training machine learning models, and may be used by real-time, in-vehicle drowsiness detection systems that infer driver drowsiness levels based on captured images. In various embodiments, a circadian rhythm drowsiness estimate may be used to correct, calibrate, augment, and / or replace a drowsiness score predicted by a machine learning model.

In various examples, circadian rhythm-based data augmentation for drowsiness detection systems and applications are provided. Embodiments described herein may produce an estimated circadian rhythm for a test subject and / or vehicle driver or other machine operator or occupant, and use the pattern of that circadian rhythm to correct, confirm, calibrate, or otherwise augment drowsiness assessments derived from video image data. The position of a person in the context of their process C circadian cycle may be used as indication of their level of drowsiness. An estimated process C circadian cycle may be used to generate more accurate ground truth training data for training machine learning models, and may be used by real-time, in-vehicle drowsiness detection systems that infer driver drowsiness levels based on captured images. In various embodiments, a circadian rhythm drowsiness estimate may be used to correct, calibrate, augment, and / or replace a drowsiness score predicted by a machine learning model.

The invention discloses a humanoid robot walking and running unified control method and system based on a biological rhythm, and belongs to the technical field of humanoid robots. Capturing human walking and running action data, and extracting rhythm features from frequency and phase time domains; constructing a rhythm generator based on the rhythm features extracted in the step 1; according to a strategy gradient method based on a constraint reinforcement learning algorithm, a walking and running unified control strategy is constructed, rhythm information generated based on a rhythm generator is adopted in the walking and running unified control strategy, then action-critic is used for training, a bionic motion control system Walk2Run under speed driving is jointly constructed, natural gait transition and frequency adjustment are achieved, and the walking and running unified control strategy is obtained. And meanwhile, the physical capacity limitation of the robot is met, and motion fluency and energy efficiency are improved. The problems that an existing humanoid robot does not achieve energy optimization of human walking during walking, and mobility of an existing data set has high requirements for the motion ability of the robot and is poor in generalization ability are solved.

The invention belongs to the technical field of sleep-aiding oral liquids, and discloses a sleep-aiding nerve-calming oral liquid and a preparation process thereof, the oral liquid is composed of the following components: a plant fermentation broth, fructo-oligosaccharide, gamma-aminobutyric acid, casein hydrolysis peptide, a saussurea involucrata culture, and pyrroloquinoline quinone disodium salt; wherein the plant fermentation liquor is prepared from spina date seeds, poria cocos, lilies, Chinese dates, lotus seeds, lophatherum gracile, seville orange flowers, red roses with double petals, roselle, wheat, licorice roots, peach kernels, sweet-scented osmanthus and plant lactobacillus BXM2. The core component spina date seed saponin A is combined with gamma-aminobutyric acid to directly regulate the GABAergic nervous system, shorten the sleep latency and effectively help sleep and tranquilize the nerves; casein hydrolysis peptide promotes secretion of melatonin, and cooperates with the saussurea involucrata culture to resist oxidative stress, improve the sleep structure and restore circadian rhythm; small molecular active peptides and flavonoid glycosides are generated through fermentation, and anxiety mood, fatigue state and qi and blood circulation are improved; nano embedding and targeted delivery technologies are adopted in the whole process, the bioavailability is high, and the risk of drug dependence is avoided.

The invention relates to the technical field of medical monitoring, in particular to a monitoring and early warning system for adverse reactions after vaccination, which comprises a circadian rhythm recognition module, an extreme value offset processing module, a stage reaction mapping module, an abnormal grade recognition module and a linkage path judgment module. According to the method, a cross matching relation between abnormal response and rhythm change is established through positioning of a day and night body temperature extreme value interval midpoint before and after inoculation and continuous tracking of a time axis coordinate change trend, and whether the abnormality has rhythm driving characteristics or not is judged through a time period alignment relation between abnormality occurrence time and a rhythm offset interval. According to the method, an early warning path identification chain is constructed, participation items are expanded to sequence trend change, rhythm structure axial displacement, abnormal signal coverage rate and other elements, the sensitive capture capability for potential risks of adverse reactions after vaccination is improved, and the linkage early warning output capability for time-structure dual abnormal performance is also enhanced.

The invention relates to the technical field of intelligent breeding, in particular to a dairy cow nutritional requirement dynamic evaluation method and system, and the method comprises the following steps: S1, calculating a circadian rhythm phase parameter; s2, establishing fiber-decomposing bacteria activity coefficients under different rhythm phases; s3, correcting the theoretical digestibility of the NDF in the roughage according to the activity coefficient of the cellulose-decomposing bacteria obtained in the S2; s4, calculating dynamic basic metabolism energy consumption for maintaining the body temperature and behavior activities in combination with data of an environment temperature and humidity sensor; s5, outputting the day and night distribution proportion of protein and energy substances; and S6, controlling a feed feeding time sequence according to the rumen pH fluctuation threshold value. By monitoring the day and night rhythm and rumen environment state of the dairy cow in real time and dynamically regulating and controlling the precise proportion and feeding time sequence of the fine and coarse feed, the feed utilization efficiency is effectively improved, high cooperation of nutrition supply and physiological needs of the dairy cow is guaranteed, and the production performance and breeding economic benefits of the dairy cow are improved.

A circadian rhythm-based time-sharing repair formula and use thereof. A day composition focuses on anti-oxidation, stress resistance and energy metabolism to resist oxidative damage and enhance day vitality and provide long-lasting antioxidation protection. A night composition focuses on DNA repair, anti-inflammation and nerve relaxation to promote cell regeneration and repair and continuously support night repair. The composition of the day composition and the night composition designed according to the circadian rhythm of human metabolism causes the corresponding activities to take effect at the best time, and components are designed to cooperate with each other according to different physiological needs during the day / night, which can greatly improve the anti-aging effect.

The invention relates to the technical field of air traffic management, and discloses an in-post controller fatigue prediction method based on a work type and a circadian rhythm, and the method comprises the steps: obtaining a face video frame in a controller post, and carrying out the calculation to obtain a PERCLOS time sequence representing an eyelid closing proportion; obtaining an exogenous factor related to the control task; the PERCLOS time sequence and the ectogenic factors are coded and input to a trained time sequence neural network model, and the time sequence neural network model is configured to apply different weights to the work types, the circadian rhythms and the work requirements so as to carry out differential modeling; and generating a fatigue level curve covering a preset prediction time window based on the output of the time sequence neural network model. The invention aims to solve the technical problems that a fatigue monitoring method in the prior art is lagged in response and insufficient in adaptability to dynamic working scenes, and provides a method capable of actively and accurately predicting the future fatigue development trend of the controller.

The invention discloses bifidobacterium longum capable of regulating circadian rhythm and remarkably improving cognitive memory ability and application of the bifidobacterium longum, and belongs to the technical field of microorganisms. The bifidobacterium longum GDMCC No: 65850 provided by the invention can effectively relieve rhythm gene expression disorder caused by sleep deprivation, thereby relieving cognitive defects of mice with circadian rhythm disorder. Besides, the intervention of the bifidobacterium longum GDMCC No: 65850 can regulate the intestinal flora health and the change of the intestinal metabolite level, promote the generation of neuroprotective metabolite and reduce the cognitive ability decline caused by circadian rhythm disorder. According to the bifidobacterium longum, the application range of the bifidobacterium longum as probiotics is expanded, and the bifidobacterium longum has a huge application prospect in products for relieving cognitive memory ability decline induced by circadian rhythm disorder.

A method for improving human circadian health and protecting the eyes from high-energy visible blue light while performing activities during daytime and nighttime hours wherein an eyewear device is selected and positioned in front of the eyes of a person such that the lenses of the eyewear device substantially filter the light received by the eyes. In some variations, the lenses of the selected eyewear device for use during daytime hours provide eye protection from high-energy visible blue light and provide a transmittance of circadian blue light that is between 100 percent to 150 percent relative to the luminous transmittance of the lenses. In some variations, the lenses of the selected eyewear device for use during nighttime hours provide a transmittance of circadian blue light that is less than 40 percent, or less than 25 percent, or less than 15 percent relative to the luminous transmittance of the lenses.

The invention discloses a ctEVs separation and analysis method with time resolution capability and application thereof. The ctEVs separation and analysis method comprises the following steps: S1, culturing cells by adopting glycometabolism markers; or injecting the animal by adopting a glycometabolism marker; step S2, manufacturing a fishbone-shaped micro-fluidic chip modified by streptavidin; s3, separating and analyzing the new tumor source extracellular vesicles by the micro-fluidic chip, and co-incubating the extracellular vesicles and the aptamer probe co-modified by Biotin and DBCO to realize biotinylation of the new tumor source extracellular vesicles; the aptamer probe is a heterologous multivalent aptamer probe; step S4, capturing biotin-labeled target extracellular vesicles by adopting a chip; and S5, acquiring a chip image by using a fluorescence microscope, and analyzing the concentration of the target extracellular vesicles in the sample according to a fluorescence signal. The method can be used for screening tumor circadian rhythm markers and the like.

The invention relates to the technical field of medical typing decision, in particular to a myocardial infarction metabolic rhythm intelligent typing and administration decision method and system.The myocardial infarction metabolic rhythm intelligent typing and administration decision method comprises the steps that biological clock genes BMAL1 mRNA, a USP2-BCAT2 compound and branched chain amino acid BCAs are synchronously detected through a multi-index joint detection kit; a BCAs circadian rhythm curve is collected through a wearable monitoring patch integrating a sweat BCAs sensor and an electrocardiogram monitoring module; the invention relates to a random forest model myocardial infarction metabolic rhythm typing intelligent model. A multi-dimensional dynamic typing system is established by integrating BMAL1 methylation, a USP2-BCAT2 compound and BCAs rhythm fluctuation, and high-risk subtypes needing metabolic intervention are accurately distinguished; the concentration fluctuation of the BCAs is monitored in real time through the intelligent patch, and the abnormal metabolism state is pre-warned; and the administration opportunity is automatically optimized based on the individualized biological clock phase, and clinical pain points such as insufficient typing precision, abnormal early warning lag and administration time sequence mismatch are solved.

A circadian phase adjustment method, system and device, and a storage medium, the method comprising: acquiring circadian phase information of a user, including target sleep time and target wake time of a target day; obtaining a target value of rhythm phase shift of the target day based on the target falling-asleep time and the target awakening time; a target cumulant of the light dose cumulant is obtained based on the target value of the rhythm phase migration by using a phase prediction model, and the phase prediction model is a relation model of the rhythm phase migration and the light dose cumulant; acquiring an actual cumulant of the light dose cumulant based on the light environment information; and judging whether the actual cumulant of the user at the current detection moment meets the requirement or not based on the target cumulant, and executing the light intervention operation if the actual cumulant does not meet the requirement. According to the method, the target value of the light dose cumulant required by the user on the target day is quantified, intervention is performed based on the actual light dose cumulant, and the accuracy of circadian rhythm phase adjustment is improved.

This invention belongs to the technical field of sleep quality analysis, specifically relating to a sleep quality analysis system and method based on sensors in a medical bed, to address the technical problem of existing methods relying too heavily on duration statistics while neglecting the continuity and circadian rhythm of sleep. The analysis method includes: S1, acquiring vital sign signal data collected by sensors in the medical bed within a sleep cycle and dividing it into multiple continuous time segments; S2, extracting physiological indicators such as respiratory rate, heart rate, and body movement amplitude within each time segment, and calculating the variability depth of the corresponding time segment; S3, generating a variability depth baseline; calculating non-steady-state disturbance factors based on the frequency and duration of micro-awakening disturbance segments; and S4, generating a comprehensive sleep quality score. The analysis method of this invention improves the comprehensiveness and objectivity of the assessment results, more realistically reflecting sleep health status.

The invention discloses an application of a 5, 7-dihydroxy flavonoid compound in preparation of a circadian rhythm regulation product. It is found for the first time that 5, 7-dihydroxy flavonoid compounds can enable cell phases to move backwards, regulate expression of core biological clock protein, inhibit cell HDAC3 activity, reduce REV-ERB alpha protein expression stability and restore mouse pressure to aggravate biological clock protein expression disorder after colitis, and therefore the effect of preventing and treating colitis is achieved. Therefore, the 5, 7-dihydroxy flavonoid compound can be used as an anti-colitis drug targeting a biological clock system, and has important significance in treating related diseases caused by biological clock disorder.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The technology relates in part to methods for measuring circadian rhythm factors. In some aspects, the technology relates to measuring circadian rhythm factor metabolites. In some aspects, the technology relates to measuring melatonin metabolites. In some aspects, the technology relates to measuring melatonin metabolites and estimating circadian rhythm phase markers according to a distribution function.

The present application relates to a kind of circadian rhythm-based circulating water aquaculture fish pond dissolved oxygen mechanism modeling method, including the influence of fish respiration consumption, water surface atmospheric reoxygenation, circulating water flow, mechanical aeration factor on dissolved oxygen dynamic change;According to oxygen transfer equation, considering the influence of the above four factors on fish pond dissolved oxygen, the dissolved oxygen mechanism model of circulating water aquaculture fish pond is established;Combined with oxygen transfer equation and the characteristics of fish respiratory activity changes between day and night, the influence of fish respiratory circadian rhythm on the model is analyzed, and the model is verified.The present application can more accurately reflect the high and low peak value in different time periods and also capture the dynamic changes presented in the whole cycle, and effectively avoid the loss and risk caused by the inaccurate model description to the aquaculture industry in extreme breeding environment or abnormal environment.

The invention relates to application of migratory locust rhythm gene Clock in regulation and control of eclosion rhythm. According to the method, dsRNA of the migratory locust rhythm gene Clock is injected into a migratory locust body cavity, the expression quantity of the migratory locust rhythm gene Clock is remarkably reduced, the circadian rhythm and daily rhythm of migratory locust are both changed by regulating synthesis of 20E, living work and rest formed by long-term coevolution of migratory locust and the external environment are disrupted, serious harm is caused to survival and reproduction of migratory locust, and the migratory locust is prevented from being damaged. And a new way is provided for pest control.

A method for estimating adaptation of a circadian rhythm of a user, the method comprising: measuring a circadian phase of the user by using at least one of a skin temperature sensor, a cardiac activity sensor, and a motion sensor; measuring a sleep-wake rhythm of the user by using at least one of the cardiac activity sensor and the motion sensor, and detecting a change in the sleep-wake rhythm of the user based on the measurement; determining a setpoint phase of a circadian phase based on the altered sleep-wake rhythm; determining a target day and night phase based on the position of the user; determining a diurnal adaptation rate based on a first adaptation rate if the setpoint phase and the target phase are in the same direction with respect to the current diurnal phase, and determining a diurnal adaptation rate based on a second adaptation rate if the setpoint phase and the target phase are in opposite directions from the current diurnal phase, wherein the second adaptation rate is smaller than the first adaptation rate; and outputting, via an interface, a derived parameter of the determined circadian adaptation or the calculated circadian adaptation to be presented to a user.

A method of managing a disorder associated with a circadian rhythm disorder in a subject by administering to the subject an effective amount of a beta glucan oligosaccharide and / or an arabinose oligosaccharide. More specifically, the management includes treating a symptom associated with a circadian rhythm disorder, primary preventing a symptom associated with a circadian rhythm disorder, secondary preventing a symptom associated with a circadian rhythm disorder, and / or delaying progression of a symptom associated with a circadian rhythm disorder. The symptoms to be managed include symptoms related to sleep, symptoms related to emotion, symptoms related to cognitive function decline and neurocognitive decline, and the like. In particular methods herein, the risk of developing a symptom associated with a circadian rhythm disorder in the subject is assessed prior to administration of the beta glucan oligosaccharide and / or arabinose oligosaccharide. Also provided are medicaments, nutritional formulations, nutritional supplements and pharmaceutical compositions comprising an effective amount of beta glucan oligosaccharides and / or arabinose oligosaccharides for use in such treatment, prevention and delay.

The invention relates to the field of economic animal feeding, and particularly discloses a technical method for promoting efficient and healthy breeding of bumblebees based on circadian rhythm, which comprises the following steps: breaking the diapause state of queen bees by using high-concentration COs, recovering the activity of the queen bees, transferring the recovered queen bees into an early-stage queen bee nesting feeding box, and providing normal pollen and liquid food; putting the queen bee breeding box into an incubator, simulating a natural photoperiod environment at the temperature of 28-29 DEG C and the humidity of 50-60%, and helping the queen bee to adapt to the circadian rhythm; at the beginning, the feeding amount of the queen bees every day is equal to the size of soybeans, and after the first batch of worker bees are hatched, the queen bees, the worker bees and honeycombs are transferred into a larger feeding box; according to the method, the biological clock of the queen bee is adjusted by controlling time service factors such as illumination, temperature, humidity and food, the survival rate of the queen bee is remarkably increased, the growth and development of the queen bee and the health state of a swarm are improved, and the technical method for promoting efficient and healthy breeding of the bumblebees based on the circadian rhythm is established.

Targeting mitochondrial function is a strategy for preventing metabolic disorders, but restoring mitochondria diurnal regulation remains to be explored. Using targeted metabolomics, we identified 24-hour mitochondrial rhythms promoted by nocturnal time-restricted feeding (TRF) in mice fed a high-fat diet (HFD). Preceding its metabolic benefits, TRF promoted mitochondrial daily rhythms by converging on the enzyme dihydroorotate dehydrogenase (DHODH), which coordinates pyrimidine biosynthesis and mitochondrial oxidative metabolism. The inhibition of DHODH activity by the short half-life inhibitor BAY-2402234 modulated mitochondrial oxidative metabolism, thereby preventing diet-induced obesity, but only when injected at the transition between night and day. This timed inhibition of DHODH promoted oscillations in mitochondrial metabolic pathways and oscillations in the CoQ / CoQH2 ratio, improving metabolic adaptation to the HFD challenge. Our results highlight the role of mitochondrial daily rhythms in the pathophysiology of obesity and open avenues for chronopharmacological treatments targeting these rhythms. Thus, the present invention pertains to a method for treating or preventing obesity in a subject in need thereof. This method includes administering to the subject, at a specific time of the circadian rhythm, a therapeutically effective amount of a dihydroorotate dehydrogenase inhibitor that exhibits an inhibitory duration of less than 24 hours, and more specifically, a short half-life of less than 24 hours.

In the present invention, a rhythm estimation unit (105), using a prediction formula created based on the phase response curve of a circannual rhythm, estimates the circadian rhythm of a subject from: changes in biological information throughout a day of the subject, measured by a body temperature sensor (101); a light stimulation time, which is the time at which a light stimulation state is determined by a first determination unit (103); and an awakening time, which is the time at which an awakening state is determined by a second determination unit (104), where the estimation is made for the day after the changes in biological information of the subject is measured by a body temperature sensor (101). The rhythm estimation unit (105) outputs the estimated circadian rhythm. The outputted circadian rhythm is displayed on a display unit (107), for example.

The invention belongs to the field of plant genes, and relates to application and a method of a GmTOC1a gene or protein in regulation and control of soybean flowering. The application of the soybean biological clock gene GmTOC1a in flowering control is found, two homologous copies GmTOC1a1 (Glyma. 05G025000) and GmTOC1a2 (Glyma. 17G102200) of the GmTOC1a gene are directionally knocked out through a CRISPR / Cas9 gene editing technology, a soybean mutant with the GmTOC1a gene mutated is obtained, research finds that the mutant shortens the growth period of soybeans and advances the flowering time, and it is indicated that the GmTOC1a inhibits soybean flowering. Therefore, the GmTOC1a gene can be applied to change or expand the cultivation regionalism of soybeans, so that the soybeans can be sown at different latitudes, the planting region of the soybeans is expanded, and a theoretical basis and genetic resources are provided for breeding good varieties of the soybeans.

The invention discloses a melatonin secretion moment detection method, device and equipment, a medium and a program product, and relates to the technical field of physiological rhythm monitoring, and the melatonin secretion moment detection method comprises the steps of obtaining original heart rate data of a user at a first moment; performing first filtering processing based on a circadian rhythm period on the original heart rate data to obtain first heart rate data; determining second heart rate data according to the original heart rate data and the first heart rate data; performing second filtering processing on the second heart rate data based on an over-daily rhythm period to obtain third heart rate data; fusing the first heart rate data and the third heart rate data to obtain target heart rate data; according to the target heart rate data at the first moment and the target heart rate data at the at least one second moment, the melatonin secretion moment of the user is determined, and the detection accuracy of the melatonin secretion moment is improved.

A method of determining and presenting a protocol for adjusting a circadian rhythm of a user including receiving first and second indications of first and second intended circadian shifts comprising shift magnitudes, receiving first and second indications of first and second user circadian phases, defining first and second user circadian shift protocols responsive to the shift magnitude and the indication of the user circadian phase, the user circadian shift protocol comprising one or more activities scheduled to be performed at a certain date and time, the activities comprising at least one of a light exposure or light avoidance activity, a chronobiotic activity, a nutritional consumption activity, a physical activity, and a rest activity. The method may further provide indications to perform each activity on first and second user devices.

The invention provides an illumination system arranged to illuminate a space for rearing a flock of birds, wherein the illumination system comprises: a visible light source configured to emit visible light; an ultraviolet light source configured to emit ultraviolet light; a controller configured to: (i) entrain a circadian rhythm of the flock of birds by controlling the visible light source to emit the visible light for a predetermined period of light, and not to emit the visible light for a predetermined period of dark; (ii) control the ultraviolet light source to emit the ultraviolet light at an ultraviolet light intensity for at least one subperiod within the predetermined period of dark, wherein the ultraviolet light comprises a peak wavelength within the UV-A wavelength range.

The invention belongs to the technical field of biology, and relates to regulation and control of a recent rhythm cycle of soybeans, in particular to application and a method of a GmCRY2a gene in regulation and control of the recent rhythm cycle of the soybeans. According to the research of the invention, two GmCRY2a genes in soybean are knocked out, and a delayed phenotype appears in a recent rhythm period. According to the CRISPR / Cas9 knockout technology constructed by the invention, pure and gmcry2a1a2 mutant soybean plants can be obtained, compared with control soybeans, the recent rhythm of the soybeans is obviously delayed, and the CRISPR / Cas9 knockout technology can be applied to screening of the soybeans suitable for multi-latitude region growth and has a huge application prospect.