105 results about "Circadian process" patented technology

The invention discloses a humanoid robot walking and running unified control method and system based on a biological rhythm, and belongs to the technical field of humanoid robots. Capturing human walking and running action data, and extracting rhythm features from frequency and phase time domains; constructing a rhythm generator based on the rhythm features extracted in the step 1; according to a strategy gradient method based on a constraint reinforcement learning algorithm, a walking and running unified control strategy is constructed, rhythm information generated based on a rhythm generator is adopted in the walking and running unified control strategy, then action-critic is used for training, a bionic motion control system Walk2Run under speed driving is jointly constructed, natural gait transition and frequency adjustment are achieved, and the walking and running unified control strategy is obtained. And meanwhile, the physical capacity limitation of the robot is met, and motion fluency and energy efficiency are improved. The problems that an existing humanoid robot does not achieve energy optimization of human walking during walking, and mobility of an existing data set has high requirements for the motion ability of the robot and is poor in generalization ability are solved.

The invention relates to the technical field of air traffic management, and discloses an in-post controller fatigue prediction method based on a work type and a circadian rhythm, and the method comprises the steps: obtaining a face video frame in a controller post, and carrying out the calculation to obtain a PERCLOS time sequence representing an eyelid closing proportion; obtaining an exogenous factor related to the control task; the PERCLOS time sequence and the ectogenic factors are coded and input to a trained time sequence neural network model, and the time sequence neural network model is configured to apply different weights to the work types, the circadian rhythms and the work requirements so as to carry out differential modeling; and generating a fatigue level curve covering a preset prediction time window based on the output of the time sequence neural network model. The invention aims to solve the technical problems that a fatigue monitoring method in the prior art is lagged in response and insufficient in adaptability to dynamic working scenes, and provides a method capable of actively and accurately predicting the future fatigue development trend of the controller.

The invention relates to the technical field of medical typing decision, in particular to a myocardial infarction metabolic rhythm intelligent typing and administration decision method and system.The myocardial infarction metabolic rhythm intelligent typing and administration decision method comprises the steps that biological clock genes BMAL1 mRNA, a USP2-BCAT2 compound and branched chain amino acid BCAs are synchronously detected through a multi-index joint detection kit; a BCAs circadian rhythm curve is collected through a wearable monitoring patch integrating a sweat BCAs sensor and an electrocardiogram monitoring module; the invention relates to a random forest model myocardial infarction metabolic rhythm typing intelligent model. A multi-dimensional dynamic typing system is established by integrating BMAL1 methylation, a USP2-BCAT2 compound and BCAs rhythm fluctuation, and high-risk subtypes needing metabolic intervention are accurately distinguished; the concentration fluctuation of the BCAs is monitored in real time through the intelligent patch, and the abnormal metabolism state is pre-warned; and the administration opportunity is automatically optimized based on the individualized biological clock phase, and clinical pain points such as insufficient typing precision, abnormal early warning lag and administration time sequence mismatch are solved.

This invention belongs to the technical field of sleep quality analysis, specifically relating to a sleep quality analysis system and method based on sensors in a medical bed, to address the technical problem of existing methods relying too heavily on duration statistics while neglecting the continuity and circadian rhythm of sleep. The analysis method includes: S1, acquiring vital sign signal data collected by sensors in the medical bed within a sleep cycle and dividing it into multiple continuous time segments; S2, extracting physiological indicators such as respiratory rate, heart rate, and body movement amplitude within each time segment, and calculating the variability depth of the corresponding time segment; S3, generating a variability depth baseline; calculating non-steady-state disturbance factors based on the frequency and duration of micro-awakening disturbance segments; and S4, generating a comprehensive sleep quality score. The analysis method of this invention improves the comprehensiveness and objectivity of the assessment results, more realistically reflecting sleep health status.

The invention discloses an application of a 5, 7-dihydroxy flavonoid compound in preparation of a circadian rhythm regulation product. It is found for the first time that 5, 7-dihydroxy flavonoid compounds can enable cell phases to move backwards, regulate expression of core biological clock protein, inhibit cell HDAC3 activity, reduce REV-ERB alpha protein expression stability and restore mouse pressure to aggravate biological clock protein expression disorder after colitis, and therefore the effect of preventing and treating colitis is achieved. Therefore, the 5, 7-dihydroxy flavonoid compound can be used as an anti-colitis drug targeting a biological clock system, and has important significance in treating related diseases caused by biological clock disorder.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The technology relates in part to methods for measuring circadian rhythm factors. In some aspects, the technology relates to measuring circadian rhythm factor metabolites. In some aspects, the technology relates to measuring melatonin metabolites. In some aspects, the technology relates to measuring melatonin metabolites and estimating circadian rhythm phase markers according to a distribution function.

The present application relates to a kind of circadian rhythm-based circulating water aquaculture fish pond dissolved oxygen mechanism modeling method, including the influence of fish respiration consumption, water surface atmospheric reoxygenation, circulating water flow, mechanical aeration factor on dissolved oxygen dynamic change;According to oxygen transfer equation, considering the influence of the above four factors on fish pond dissolved oxygen, the dissolved oxygen mechanism model of circulating water aquaculture fish pond is established;Combined with oxygen transfer equation and the characteristics of fish respiratory activity changes between day and night, the influence of fish respiratory circadian rhythm on the model is analyzed, and the model is verified.The present application can more accurately reflect the high and low peak value in different time periods and also capture the dynamic changes presented in the whole cycle, and effectively avoid the loss and risk caused by the inaccurate model description to the aquaculture industry in extreme breeding environment or abnormal environment.

The invention relates to application of migratory locust rhythm gene Clock in regulation and control of eclosion rhythm. According to the method, dsRNA of the migratory locust rhythm gene Clock is injected into a migratory locust body cavity, the expression quantity of the migratory locust rhythm gene Clock is remarkably reduced, the circadian rhythm and daily rhythm of migratory locust are both changed by regulating synthesis of 20E, living work and rest formed by long-term coevolution of migratory locust and the external environment are disrupted, serious harm is caused to survival and reproduction of migratory locust, and the migratory locust is prevented from being damaged. And a new way is provided for pest control.

A method of managing a disorder associated with a circadian rhythm disorder in a subject by administering to the subject an effective amount of a beta glucan oligosaccharide and / or an arabinose oligosaccharide. More specifically, the management includes treating a symptom associated with a circadian rhythm disorder, primary preventing a symptom associated with a circadian rhythm disorder, secondary preventing a symptom associated with a circadian rhythm disorder, and / or delaying progression of a symptom associated with a circadian rhythm disorder. The symptoms to be managed include symptoms related to sleep, symptoms related to emotion, symptoms related to cognitive function decline and neurocognitive decline, and the like. In particular methods herein, the risk of developing a symptom associated with a circadian rhythm disorder in the subject is assessed prior to administration of the beta glucan oligosaccharide and / or arabinose oligosaccharide. Also provided are medicaments, nutritional formulations, nutritional supplements and pharmaceutical compositions comprising an effective amount of beta glucan oligosaccharides and / or arabinose oligosaccharides for use in such treatment, prevention and delay.

The invention relates to the field of economic animal feeding, and particularly discloses a technical method for promoting efficient and healthy breeding of bumblebees based on circadian rhythm, which comprises the following steps: breaking the diapause state of queen bees by using high-concentration COs, recovering the activity of the queen bees, transferring the recovered queen bees into an early-stage queen bee nesting feeding box, and providing normal pollen and liquid food; putting the queen bee breeding box into an incubator, simulating a natural photoperiod environment at the temperature of 28-29 DEG C and the humidity of 50-60%, and helping the queen bee to adapt to the circadian rhythm; at the beginning, the feeding amount of the queen bees every day is equal to the size of soybeans, and after the first batch of worker bees are hatched, the queen bees, the worker bees and honeycombs are transferred into a larger feeding box; according to the method, the biological clock of the queen bee is adjusted by controlling time service factors such as illumination, temperature, humidity and food, the survival rate of the queen bee is remarkably increased, the growth and development of the queen bee and the health state of a swarm are improved, and the technical method for promoting efficient and healthy breeding of the bumblebees based on the circadian rhythm is established.

The invention belongs to the field of plant genes, and relates to application and a method of a GmTOC1a gene or protein in regulation and control of soybean flowering. The application of the soybean biological clock gene GmTOC1a in flowering control is found, two homologous copies GmTOC1a1 (Glyma. 05G025000) and GmTOC1a2 (Glyma. 17G102200) of the GmTOC1a gene are directionally knocked out through a CRISPR / Cas9 gene editing technology, a soybean mutant with the GmTOC1a gene mutated is obtained, research finds that the mutant shortens the growth period of soybeans and advances the flowering time, and it is indicated that the GmTOC1a inhibits soybean flowering. Therefore, the GmTOC1a gene can be applied to change or expand the cultivation regionalism of soybeans, so that the soybeans can be sown at different latitudes, the planting region of the soybeans is expanded, and a theoretical basis and genetic resources are provided for breeding good varieties of the soybeans.

The invention discloses a melatonin secretion moment detection method, device and equipment, a medium and a program product, and relates to the technical field of physiological rhythm monitoring, and the melatonin secretion moment detection method comprises the steps of obtaining original heart rate data of a user at a first moment; performing first filtering processing based on a circadian rhythm period on the original heart rate data to obtain first heart rate data; determining second heart rate data according to the original heart rate data and the first heart rate data; performing second filtering processing on the second heart rate data based on an over-daily rhythm period to obtain third heart rate data; fusing the first heart rate data and the third heart rate data to obtain target heart rate data; according to the target heart rate data at the first moment and the target heart rate data at the at least one second moment, the melatonin secretion moment of the user is determined, and the detection accuracy of the melatonin secretion moment is improved.

The invention provides an illumination system arranged to illuminate a space for rearing a flock of birds, wherein the illumination system comprises: a visible light source configured to emit visible light; an ultraviolet light source configured to emit ultraviolet light; a controller configured to: (i) entrain a circadian rhythm of the flock of birds by controlling the visible light source to emit the visible light for a predetermined period of light, and not to emit the visible light for a predetermined period of dark; (ii) control the ultraviolet light source to emit the ultraviolet light at an ultraviolet light intensity for at least one subperiod within the predetermined period of dark, wherein the ultraviolet light comprises a peak wavelength within the UV-A wavelength range.

The invention belongs to the technical field of biology, and relates to regulation and control of a recent rhythm cycle of soybeans, in particular to application and a method of a GmCRY2a gene in regulation and control of the recent rhythm cycle of the soybeans. According to the research of the invention, two GmCRY2a genes in soybean are knocked out, and a delayed phenotype appears in a recent rhythm period. According to the CRISPR / Cas9 knockout technology constructed by the invention, pure and gmcry2a1a2 mutant soybean plants can be obtained, compared with control soybeans, the recent rhythm of the soybeans is obviously delayed, and the CRISPR / Cas9 knockout technology can be applied to screening of the soybeans suitable for multi-latitude region growth and has a huge application prospect.

Disclosed are a myopia prevention lighting apparatus and a control method thereof, capable of enhancing the circadian rhythm by adjusting the illuminance of a lighting unit. A myopia prevention lighting apparatus according to an aspect of the present disclosure may comprise an LED lighting unit including a white LED that emits white light, a blue LED that emits blue light, and a red LED that emits red light having a wavelength range longer than that of the blue LED; a power supply unit configured to supply power to the LED lighting unit; a timer configured to measure time in order to determine day and night cycles; a light quantity adjustment unit configured to adjust the amounts of the white light, the blue light, and the red light by regulating power supplied from the power supply unit; and a control unit configured to control the light quantity adjustment unit according to a programmed setting such that the mixing ratios of the white light, the blue light, and the red light are adjusted over time to be equal to or greater than 5,000 lux for a certain period during the daytime and equal to or less than 500 lux for a certain period during the nighttime.

The application discloses a method for identifying Klebsiella pneumoniae gene circadian rhythm expression by using a bioluminescence reporting system. The application constructs a recombinant bioluminescence Klebsiella pneumoniae driven by a metabolic gene malate:quinone oxidoreductase mqo promoter (Pmqo), and directly observes the change rule of bacterial gene expression under entrainment and free-running conditions of temperature cycle by monitoring the luminescence characteristics. The luxCDABE gene operon comprises genes for coding luciferase and substrate synthesis enzyme, wherein luxA and luxB code for heterodimer luciferase, luxC, luxD and luxE synthesize aldehyde as a substrate for the luciferase luminescence reaction. The luciferase catalyzes the oxidation of aldehyde to generate visible blue-green light with a wavelength of 450-490 nm. The Lux bioluminescence reporting system has the advantages of not needing to add an exogenous substrate and not affecting the normal physiological functions of the host, and can be applied to the identification of Klebsiella pneumoniae gene circadian rhythm expression.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl)oxy)acetamidolbenzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMALl interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The application discloses a method and system for monitoring light and sleep and improving sleep and circadian rhythm, and aims at the problems of single application scene and function, lagging theory and lack of deep analysis in existing sleep intervention methods, adopts sleep monitoring and light improvement services based on the non-visual effect theory of light, forms the cyclic regulation and feedback of sleep and light monitoring, analysis and evaluation and sleep intervention guidance, guides users to select appropriate lighting lamps, light exposure time and total amount, utilizes light which is strong synchronization and non-contact to improve the circadian rhythm and sleep of personnel, and thus the system can be suitable for the sleep habits of each user and keep a stable circadian rhythm.

Provided herein are methods and devices for determining a personalized circadian rhythm identification and prediction from wearable data comprising: obtaining or having obtained data from one or more wearable devices during one or more daytime and nighttime cycles; using a processor and a machine learning algorithm comprising: determining a daytime threshold and a nighttime threshold from the data obtained during the one or more daytime and nighttime cycles by: temporally segmenting the data; identifying one or more daytime and nighttime boundary by: selecting from at least one of physical activity, heart rate, or sleep status data; temporally segmenting the physical activity, heart rate, or sleep status data to establish a circadian rhythm; using at least one of a 2-mean, 5-mean, or K-nearest neighbor algorithm to determine the one or more daytime and sleeptime boundaries; and identifying and predicting the personalized circadian rhythm.

The present invention relates to a bracelet and system for regulating the circadian rhythm, the bracelet comprising an electronic control module integrated into an enclosing body, said module being connected to a core in direct contact with the user's skin. The control module comprises a communication module connected to a microcontroller including a digital timer, the communication module and the microcontroller being connected to an electrical power source. The core comprises an activation mechanism including an actuator, connected to the microcontroller of the control module that acts on a melatonin microsphere reservoir, which is in contact with distribution microchannels that are connected to biodegradable microneedles in contact with the user's skin and which apply the melatonin transdermally. Said bracelet is integrated into a system.

The present application relates to the technical field of LED lighting, and discloses a light spectrum packaging structure for adjusting day rhythm, which comprises an outer box body, the outer box body comprises a box body and an end cover matched with the box body, characterized in that: a light source box is further arranged in the outer box body, the light source box is a light emitting source, an adjusting mechanism is further arranged in the outer box body, and the adjusting mechanism is used for heat conduction; the adjusting mechanism comprises a protrusion arranged in the box body, a refracting mirror matched with the protrusion is arranged on the light source box, and the refracting mirror is used for refracting light rays. The light spectrum packaging structure for adjusting day rhythm can balance the temperature difference in the outer box body between morning and evening, so that the light source box is not damaged due to overheating or overcooling caused by time period change, the adjusting mechanism is arranged in the outer box body, the adjusting mechanism can collect the temperature in the outer box body in the daytime and release the temperature at night, and the day and night temperatures in the outer box body are balanced.

The present invention provides a kind of nucleoside analogue compounds, and a composition comprising the compound and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via the compound or the composition.

The application provides a culture method and a verification method for evaluating a model of circadian rhythm, and belongs to the field of disorder model establishment and active substance function evaluation. By culturing nematodes with normal circadian rhythm and nematodes with circadian rhythm disorder, a model for evaluating circadian rhythm is established. The method is simple and easy to control, can more accurately simulate the influence of environmental factors on circadian rhythm, and lays a foundation for establishing a stable and repeatable evaluation model of circadian rhythm disorder. Whether the circadian rhythm of the nematodes is normal or not is effectively verified by the following method: a test plate is prepared, the nematodes with normal circadian rhythm or the nematodes with circadian rhythm disorder are placed in a test area; a fixed volume of an inducer is added at a fixed position, and the test plate is covered; nematode numbers in different areas of multiple test plates are counted at intervals of a fixed time; a chemotaxis index is calculated to verify the circadian rhythm.

To provide a novel circadian rhythm regulator. [Solution] A circadian rhythm regulator comprising a phthalide compound having at least one substituent R on a benzene ring as an active ingredient, wherein the at least one substituent R is independently selected from the group consisting of hydroxy, methoxy, ethoxy, propoxy, hydroxymethyl, and acetoxy.

The invention discloses a photo-activated promoter 4 * pLRE-cPAOX1 in pichia pastoris. The photo-activated promoter 4 * pLRE-cPAOX1 is prepared by inserting four photo-response elements pLRE of a neurospora crassa circadian rhythm system into the 5'end of a core promoter of pichia pastoris AOX1 in series; and meanwhile, a PGAP-WC1-Mit1AD expression cassette and a P0472-WC2 expression cassette are simultaneously inserted into the carrier pGAPZ alpha, so that a high-expression chassis strain is constructed. The light-activated promoter can work only in the chassis strain. Wherein the sequence of the WC1-Mit1AD is as shown in SEQ ID NO: 31 and SEQ ID NO: 30, the sequence of the WC2 is as shown in SEQ ID NO: 32, and the sequence of the 4 * pLRE-cPAOX1 is as shown in SEQ ID NO: 29. By adopting the light regulation and control element disclosed by the invention, the target gene expression level of pichia pastoris can be regulated and controlled by controlling the existence and intensity of illumination.

The invention provides a light control method and system for a smart home, and the method comprises the steps: obtaining the current time and the longitude and latitude information of the smart home; dividing a circadian rhythm period according to the latitude and longitude information, and determining a target circadian rhythm period including the current time; determining a first preset light parameter corresponding to the target circadian rhythm period according to the first corresponding relation; wherein the first corresponding relation is used for representing the corresponding relation between the circadian rhythm time period and the preset light parameters; and adjusting the light of the smart home according to the first preset light parameter. Dynamic adaptation of light parameters of the smart home is achieved, light adjustment and the actual environment of the smart home are completely synchronized, circadian rhythm dislocation during cross-time-zone use is avoided, manual intervention of a user is not needed, the operation burden is reduced, and use convenience is improved; accurate circadian rhythm matching can better accord with the physiological law of the human body, and the use experience of the user is improved.

The invention relates to an anti-depression compound 4-methyl-6-methoxy coumarin, and belongs to the technical field of biological medicines. Depression is the most common mental disorder in the world and is also a main reason for disability. The development of a novel anti-depression drug which is based on a nerve plasticity mechanism, takes effect quickly, has a lasting curative effect and is high in safety, and particularly has important clinical requirements and technical necessity for an effective treatment means for refractory depression. Traditional Chinese medicine monomers and a per2- / -zebra fish depression model are adopted for anti-depression drug screening, and finally it is found that 10 mM of 4-methyl-6-methoxycoumarin has the anti-depression characteristic and has the positive treatment effect on the exploration behavior, social interaction and sleep-awakening period of per2- / -zebra fish. The method can effectively rescue and reverse depression-like phenotypes observed in a per2- / -zebra fish circadian rhythmic depression model, and can restore the balance of important gene expression.

The invention relates to the technical field of nutritional foods, and particularly discloses a nutritional composition for regulating sleep as well as a preparation method and application of the nutritional composition. The nutritional composition is prepared from cow milk exosome, 1, 3-dioleic acid 2-palmitic acid triglyceride and 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride. The nutritional composition provided by the invention can promote the expression level of gamma-aminobutyric acid receptors and melatonin so as to achieve the purposes of improving sleep, assisting in regulating circadian rhythm and increasing deep sleep proportion, and a new idea is provided for preparing nutritional foods for regulating sleep.

The invention discloses a preparation method and device of a circadian rhythm adaptive anti-fatigue kidney power concentrated essence beverage. The method comprises the following steps: S1, boiling raw materials; S2, crushing the raw materials; S3, brewing; the device comprises preparation equipment, a screen plate located above a hollow crushing cone is fixed in a fixed cylinder, a fixed crushing cone matched with the hollow crushing cone and used for crushing raw materials is fixed at the bottom of the screen plate, and a filter screen is installed at the upper end of the fixed cylinder. The beverage is remarkable in effect, various natural raw materials synergistically resist fatigue, enhance kidney power and adapt to circadian rhythm, the beverage is boiled firstly and then circularly crushed, effective components are fully extracted, brewing and special filtration are performed to improve the quality of the beverage, the raw materials are efficiently conveyed and crushed, the anti-blocking and cleaning functions are powerful, the cooling efficiency is high, the preparation time can be shortened, and the stability can be improved; boiling, crushing, filtering and cooling are integrated, so that the investment of equipment is reduced.