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Sleep improving composition and preparation method thereof

A technology for improving sleep and composition, which is applied in the field of sleep improving composition and its preparation, can solve the problems of lack of energy, increase the burden on the liver and kidney, and the effect is not confirmed, so as to improve sleep, increase the incidence of falling asleep, Toxic effects

Active Publication Date: 2015-08-12
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, not only the effects of these drugs are mostly unaffirmed, but most sleeping pills are metabolized by the liver and kidneys in the body. Long-term use will increase the burden on the liver and kidneys, and some will cause liver enlargement, pain in the liver area, jaundice, and edema , proteinuria, hematuria and nausea, abdominal distension, loss of appetite, constipation and other liver and kidney damage and gastrointestinal reactions
Some sleeping pills can also cause accumulated poisoning symptoms such as lack of energy, mental decline, and blood pressure drop, and even cause respiratory and circulatory dysfunction.

Method used

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  • Sleep improving composition and preparation method thereof
  • Sleep improving composition and preparation method thereof
  • Sleep improving composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] The preparation of embodiment 1 apple stem cell freeze-dried powder

[0092] 1. The formula of the culture medium:

[0093] 1.1 Induction medium: MS solid medium + NAA0.5mg / L + BA 2mg / L + CH 1mg / L, pH value is 6.0;

[0094] 1.2 Proliferation medium: MS liquid medium+2,4-D 2.0mg / L+BA 1.0mg / L+CH1.0mg / L+AC 1.0mg / L, pH value is 6.0;

[0095] 2. Sterilization of apple branches

[0096] Choose green-planted apple trees free of chemical fertilizer and pesticide pollution, and select 10 10cm-long new shoots according to certain criteria; wash the surface attachments on the new shoots with 2L of sterile water; soak the new shoots in 120mg / L L-ascorbic acid 1 minute; sterilize new shoots in 75% ethanol solution for 1 minute, rinse with 2L sterile water; put them in 30% hydrogen peroxide solution for sterilization for 20 minutes, and rinse with sterile water for 10 minutes.

[0097] 3. Induction of cambium tissue

[0098] Use an inoculation knife to peel off the cambium, phloe...

Embodiment 2

[0107] Embodiment 2 improves the preparation of sleep composition

[0108] First, 100g of apple stem cell freeze-dried powder, 0.5g of melatonin, and 2.5g of vitamin B6 are pulverized respectively (among them, the apple stem cell freeze-dried powder is ground with liquid nitrogen, and the melatonin and vitamin B6 are generally ground), and passed through 100 mesh sieve, and then mix the pulverized and sieved materials evenly in a mixer.

Embodiment 3

[0109] Embodiment 3 improves the preparation of sleep composition

[0110] First, 100g of apple stem cell freeze-dried powder, 2.5g of melatonin, and 65g of vitamin B are pulverized respectively (wherein, the apple stem cell freeze-dried powder is ground with liquid nitrogen, and the melatonin and vitamin B6 are generally ground), passed through a 100-mesh sieve, Then mix the pulverized and sieved materials evenly in a mixer.

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Abstract

The present invention relates to the technical field of health products, particularly to a sleep improving composition and a preparation method thereof. According to the present invention, apple stem cell freeze-drying powder, melatonin and vitamin B6 are compounded so as to provide characteristics of significant sleep improvement function and no toxic-side effect; experiment results show that the sleep improving effect of the composition of the present invention is significantly superior to the sleep improving effect of the single use of each component, and mouse acute toxicity test results show that the mouse does not present abnormality and no poisoning or death occur; and the falling-asleep occurrence rate of the mice with the sub-threshold dose of sodium pentobarbital can be effectively improved under the composition dose of 0.5 g / kg.

Description

technical field [0001] The invention relates to the technical field of health care products, in particular to a composition for improving sleep and a preparation method thereof. Background technique [0002] The modern fast-paced life and gradually fierce competitions make people more and more mentally stressed. Long-term mental tension and a series of irregular life rhythms cause insomnia that has always troubled most people. According to statistics, my country's insomniacs account for 20% to 30% of the total population, and middle-aged and elderly people account for about 70%. Long-term insomnia can easily cause restlessness, fatigue, and even headache, dreaminess, sweating, and memory loss. It can also cause a series of clinical symptoms and induce some psychosomatic diseases. The reduction of work efficiency due to physical ailments increases the psychological pressure of insomniacs. Such a vicious circle leads to neurasthenia, endocrine disorders, etc., and even develo...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K9/20A23L1/29A61P25/20A61K31/4045A61K31/4415A23L33/00
Inventor 陈海佳王一飞葛啸虎黎娟妹戴国胜程建强
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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