Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of pepper extractives in preparation of sedative hypnotic medicines or health foods

A pepper extract, sedative and hypnotic technology, applied in application, food preparation, drug combination and other directions

Inactive Publication Date: 2013-02-13
SHENYANG PHARMA UNIVERSITY
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention has not seen the report about the sedative-hypnotic effect of pepper extract before

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of pepper extractives in preparation of sedative hypnotic medicines or health foods
  • Application of pepper extractives in preparation of sedative hypnotic medicines or health foods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Black pepper extract was prepared by carbon dioxide supercritical fluid extraction.

[0018] Take 100g of black pepper, crush it appropriately, pass through a 60-mesh sieve, put it into an extraction kettle, and under appropriate extraction conditions (extraction pressure 30MPa, temperature 60°C, entrainer is 95% ethanol, entrainer dosage 1:0.5 w / v ) was continuously extracted for 2 hours, and the effluent in the separation tank was dried under reduced pressure to obtain black pepper extract. The yield calculated by weighing is 7.7%. Through HPLC assay, the content of piperine in this black pepper extract is 68.9%, see attached figure 1 . (For HPLC content determination conditions, see the 2010 edition of "Chinese Pharmacopoeia", P227)

Embodiment 2

[0020] White pepper extract was prepared by ethanol reflux extraction.

[0021] Take 100g of white pepper, crush it properly, pass through a 60-mesh sieve, put it into a 2000ml round bottom flask, add 1000ml of 75% ethanol to it, and extract 3 times, each time for 1 hour. The extracts were combined, concentrated under reduced pressure, and dried to obtain the white pepper extract. The calculated yield by weighing is 18.3%. Through HPLC assay, the content of piperine in this white pepper extract is 22.9%, see attached figure 1 . (For HPLC content determination conditions, see the 2010 edition of "Chinese Pharmacopoeia", P227)

Embodiment 3

[0023] Effect of black pepper extract on sleep duration induced by sodium pentobarbital in mice.

[0024] Experimental materials: Kunming mice, ♂, weighing 21±3 grams (provided by the Experimental Animal Center of Shenyang Pharmaceutical University).

[0025] Drugs: Polysorbate-80 (Shanghai Dazhong Pharmaceutical Factory); Pentobarbital Sodium (Beijing Second Pharmaceutical Factory). Black pepper extract (33.2% piperine content as determined by HPLC) was prepared as a suspension using 2% polysorbate-80.

[0026] Test method: Mice were divided into 4 groups, 10 in each group, and 2% polysorbate-80, black pepper extract 1.0, 2.0 and 4.0 mg·kg were administered orally, respectively. -1 1.0 hours later, intraperitoneal injection of pentobarbital sodium 45mg·kg -1 , observed the disappearance and recovery time of righting reflex in mice, and calculated the duration of sleep. The results showed that black pepper extract could significantly prolong the sleep time of mice induced by...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines and discloses novel application of pepper extractives in sedative-hypnotic. The pepper extractives use fruits or seeds of pepper plants as raw materials, and by means of a method of carbon dioxide supercritical fluid extraction or water extraction or ethanol extraction, the pepper extractives are obtained. By means of analysis and experimental verification of righting reflex experiments of mice and sleep time phase of rabbits, the pepper extractives have a good function of sedative-hypnotic, can be used in the development of sedative hypnotic Chinese medicines and natural medicines, and can also be used in the development of the health foods with effects of promoting sleep.

Description

technical field [0001] The invention relates to the application of pepper extract in the preparation of sedative and hypnotic drugs and health food with the effect of promoting sleep, and belongs to the field of traditional Chinese medicine and health food. Background technique [0002] Pepper is a plant belonging to the family Piperaceae, Pepper ( Piper nigrum L.) fruit. The fruits and seeds of pepper can be processed in different ways to obtain black pepper, white pepper, green pepper and red pepper. When the fruit at the base of the ear starts to turn red, cut off the ear, and after drying or drying, it becomes dark brown, and the fruit is removed, commonly known as black pepper. If all the fruits have turned red, they are harvested, soaked in water for several days, wiped off the exocarp, and dried in the sun, the surface will be grayish white, commonly known as white pepper. 80%~85% of the total pepper consumption in the world is black pepper, 15%~20% is white peppe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A23L1/29A61P25/20A23L33/00
Inventor 孙博航朱一冰黄鹏飞王亚楠葛晓磊
Owner SHENYANG PHARMA UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com