39 results about "Hypnotic drugs" patented technology

The invention relates to a sleep-improving health food composition which comprises the following raw materials by weight: 8 to 40 parts of gamma-aminobutyric acid powder, 0.8 to 8 parts of a Chinese magnoliavine extract, 5 to 20 parts of a calcium-containing compound, 5 to 20 parts of a magnesium-containing compound and 0.01 to 1 part of vitamin B6. The invention further provides a sleep-improving preparation and a preparation method thereof. The sleep-improving health food composition and the sleep-improving preparation use gamma-aminobutyric acid powder, the Chinese magnoliavine extract, the calcium-containing compound, the magnesium-containing compound and the vitamin B6 as main components, do not contain the component of hypnotics, can effectively soothe emotion of a stressed population and people with bad sleep and improve sleep quality.

The present invention consists of an apparatus for the on-line identification of drug effect using drug interactions and physiologic signals, in particular the interaction between anaesthetics and analgesics combined with the electroencephalogram for precise assessment of the level of consciousness in awake, sedated and anaesthetised patients. In a preferred embodiment the apparatus comprises: two infusion devices, for example syring pumps, which are connected to the patient (1) adapted to deliver hypnotics (2) and analgesics (3). The infusion data from the pumps are fed into an interaction model (5); an interaction model characterized by a Neural Network which is adapted to estimate the parameters of the model online and in real-time for drug interaction between anaesthetics and an analgesics, an EEG instrumentation amplifier; a processing unit adapted to calculate an EEG index of the level of consciousness (ELC); a fuzzy logic reasoner adapted to merge extracted EEG parameters into an index.

The certified doctor in United States, use pentobabital sodium as the hypnotic to refrain central nervous system. Pentobabital sodium can be patience to the body after two weeks, and the effect decrease half, and have lingering effects and remain effects. The making method and pharmacological activity about the six kinds of plants and sodium pentobarbital's synergistic action wares are gaven patent. Under the cautious and strict conditions, extract the plant ingredients, absorb them by WLD resin, separate and purify them, and use the finger mark atlas quantity to make sure that the end product poise and stabilize. Six plant compound wares have sedate, hypnotize and synergy pentobabital sodium, anti-penfourzopol. The clinical use proved the reliability. It is safe and compensatory to the pentobabital sodium. It solves the hypnotic's tolerance and addiction. It solves the problem, which is expected to conquer for a long time.

The invention relates to a methylphenidatefrozen dry powder preparation for injection and a preparation process thereof; the preparation takes the salt of the methylphenidatefrozen as drug constituents and forms the drug composite by mixing acceptable accessories pharmaceutically; the preparation method is that: the salt of the methylphenidatefrozen is taken as raw material, the accessories with specific kinds and proportion are added, and the dry powder preparation for intravenous injection is prepared and developed by adopting the illustrative technological measures. The dry powder preparation is used for treating attention deficiency hyperkinetic disorder (hyperkinetic syndrome of children and mild brain functional maladjustment), and eliminating somnolence, lassitude and respiratory depression caused by soporifics.

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

An orally disintegrating tablet of sedative-hypnotic medicine and a preparation method for the same are disclosed. The invention relates to an orally disintegrating tablet of sedative-hypnotic medicine as well as a prescription and a process for preparing the orally disintegrating tablet of sedative-hypnotic medicine by a freeze-drying method. The orally disintegrating tablet of sedative-hypnotic medicine disclosed by the invention is prepared from main medicines and pharmaceutical excipients, without the need of water while being taken, capable of being rapidly disintegrated in mouth, and suitable for the medication of the patients with difficulty in swallowing, such as the old and children; simultaneously, the orally disintegrating tablet of sedative-hypnotic medicine is suitable for the medication in a condition that water source is not easy to obtain during travelling; moreover, the orally disintegrating tablet of sedative-hypnotic medicine can avoid the influence on sleep due to micturition desire because of no need of water while being taken, thus exerting curative effect better; and the orally disintegrating tablet of sedative-hypnotic medicine disclosed by the invention has better compliance and therapeutic effect in the case that the patients with neurological disease are passive or incoordinate and for the old patients with insomnia compared with other forms, and can obviously reduce the side effects of the sedative-hypnotic medicine. Additionally, the invention further relates to a preparation method for an orally disintegrating tablet of sedative-hypnotic medicine.

The invention discloses a pharmaceutical composition with sedative and hypnotic effects. The pharmaceutical composition is a preparation prepared from the following raw material drugs in parts by weight: 4 to 6 parts of aquilariae lignum resinatum leaf, 2 to 3 parts of lucid ganoderma and 2 to 3 parts of fiveleaf gynostemma herb. A pharmacological experiment shows that the pharmaceutical composition has good sedative and hypnotic effects and is capable of obviously shortening the fall-asleep time, prolonging the sleep time and reducing automatic action, and a new selection is provided for clinically using sedative and hypnotic drugs.

The invention is directed to pharmaceutical compositions comprising colored solutions, colored emulsions, or colored powders of injectable pharmaceuticals wherein said pharmaceuticals are selected from the group consisting of muscle relaxants, hypnotics, induction agents, and anticholinergics. The formulations of the present invention may all be colored using fluorescein. Different colors may be achieved by either varying the concentration of fluorescein, or by combining fluorescein with another dye. The invention is also directed to methods involving the use of said pharmaceutical compositions.

The invention discloses a hypnotic comprising, by mass, 1-5 parts of clove, 1-4 parts of papaya, 4-8 parts of dragon teeth, 3-9 parts of greenish lily bulb, 2-5 parts of creeping liriope, 1-3 parts of villous amonmum fruit, 1-2 parts of east Asian tree fern, 1-3 parts of tsao-ko amomum fruit, 2-4 parts of medicinal fatheadtree stem and bark, 1-5 parts of giant gecko, 1-2 parts of sandalwood, 2-3 parts of Chinese knotweed herb, 2-5 parts of cluster mallow fruit, 2-4 parts of buerger pipewort head, 1-6 parts of dried bitter gourd, and 3-8 parts of dogbane leaf. The hypnotic provided by the invention has the functions of convulsion relieving, tranquilizing, heat clearing, restlessness relieving, yin nourishing, body fluid generating, lung moistening, heat-fever clearing, dampness eliminating, coldness relieving, phlegm expelling, malaria stopping, and digestion promoting.

An herbal pharmaceutical compositions of California poppy and methods for the treatment of sleep disorders and dream-related disorders is disclosed. The formulation may be in the form of capsules, tablets, caplets or other oral dosage forms and comprises preferably 600 to 2400 mg of a ratio of 4-10 parts (wt) dried plant material to 1 part (wt) aqueous alcohol (50-90 vol % ethanol) extract that is equivalent to 3-12 grams of the dried herb top of California poppy and contain at least 0.8 wt % isoquinoline alkaloids. The composition may further comprise isoquinoline alkaloids whose composition contains Californidine, Escholtzine and Protopine. California poppy can also be used as a therapy for managing people that have sleep and dream disorders such as Post Traumatic Stress syndrome and similar conditions that induce nightmares as well as people using tranquilizer, antidepressant, antipsychotic, sedative, hypnotic and analgesic drugs.

The invention provides a preparation method of a traditional Chinese medicine for treating blood stasis type insomnia and belongs to the technical field of preparation method of traditional Chinese medicines. At present, a sedative-hypnotic drug, an antianxiety agent or an antidepressant is commonly adopted to treat the blood stasis type insomnia, and has the defect that the toxic and side effect is serious. The technical scheme provided by the invention is as follows: the traditional Chinese medicine for treating the blood stasis type insomnia is prepared by soaking rosa chinensis, pseudo-ginseng, setose thistle, camellia japonica, field thistle, osbeckia chinensis, folium artemisiae argyi, cactus, hairyvein agrimony, rhizoma bletillae, furnace soil, crinis carbonisatus, rumex japonicas, marmor serpentinatum, radix boehmeriae, madder, common sage herb, hollyhock flower, eclipta, ossa draconis, albizia julibrissin, polygala tenuifolia, tuber fleeceflower stem, coral, semen boitae, poria with hostwood, gagea lutea, salvia miltiorrhiza and liquorice into water, then decocting for 3h by slow fire, and filtering to remove slag to obtain liquid medicine which is the traditional Chinese medicine for treating blood stasis type insomnia. The traditional Chinese medicine prepared by the method has the advantages that the toxic and side effect is low, the course of treatment is short and the curative ratio is high, and can be used for avoiding the adverse drug reaction caused by western medicines.

The invention, which relates to the field of health care product detection, provides a simultaneous detection method for illegally added medicines in a tranquilizing and allaying excitement health-care product. Specifically, the method for simultaneous determination of illegally added drugs such as benzodiazepines, barbital and atypical benzodiazepines hypnotics in tranquilizing and allaying excitement health-care products by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS-MS) comprises the steps of extraction, purification, membrane filtration, tandem triple quadrupolemass spectrometry detection and establishment of a standard curve. The method is simple in steps, high in accuracy and good in reproducibility, can be used for qualitatively and quantitatively analyzing various illegally added medicines in the health care product at the same time, and has the advantage of rapid and high-throughput detection.

The present invention provides a novel use of a Maydis stigma extract in prophylaxis, alleviation, or therapy of sleep disorder. A Maydis stigma extract has the effect of reducing sleep onset latency and increasing sleep duration, as high as or higher than the effect of ketamine or pentobarbital, which are conventionally used as soporifics. As a natural substance, the Maydis stigma extract does not cause side effects, such as cytotoxicity, resistance, or dependency, even when used for a long term.

The invention provides a hypnotic clock. The clock comprises a clock housing body, a clock device and a hypnotic device. The clock housing body is of a thin shell-type structure. Other devices are installed in the clock housing body. The clock device comprises a clock panel, a machine core, a clock switch and a cell and is used for achieving normal clock functions. The hypnotic device comprises ahypnotic switch, a control circuit, an audio selection button, a volume adjusting button, a display screen and a loudspeaker. After the hypnotic switch is pressed down, a user is capable of choosing favorite natural sound through the audio selection button. A display result is displayed on the display screen. By use of the volume adjusting button, the volume of the sound produced by the loudspeaker can be adjusted. The beneficial effects are that the clock is simple in structure, convenient to operate and highly reliable; and the clock is capable of waking up a person and helping the person tosleep by playing the natural sound, so the clock has two functions.

There is provided a formulation suitable for transmucosal administration comprising a short acting hypnotic drug, which formulation provides a measurable plasma concentration of drug within 10 minutes of administration. The formulation is capable of providing sleep on demand, and preferably comprises particles of drug, for example zolpidem or a pharmaceutically-acceptable salt thereof and a mucoadhesion promoting agent, such as sodium carboxymethylcellulose, which particles of drug and mucoadhesive are presented upon the surface of larger carrier particles.

The invention discloses a eucommia active monomer compound, the structural formula of which is shown in the specification. The invention also discloses a preparation method of the compound, a pharmaceutical composition containing the compound and pharmaceutical application of the compound. The active monomer compound is extracted from eucommia and can be extracted from eucommia bark, eucommia leaves, eucommia male flowers, eucommia seeds or whole eucommia plants. The extracted active monomer compound is 4-hydroxy-3-(2-hydroethyl)-1-cyclopentene-1,2-dimethanol, and experiments prove that the compound has obvious sedation, hypnogenesis, anti-convulsion and other effects as well as no side effect and dependence, and can be taken for a long time. The active monomer compound extracted from eucommia and the effects of the compound in the aspects of sedation, hypnogenesis, anti-convulsion and the like are provided in the invention, thereby providing a novel natural active substance for researching and developing novel health-care food and novel sedative-hypnotic drugs.