Simultaneous detection method for illegally added medicines in tranquilizing and allaying excitement health-care product

A detection method, calming and calming technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of weak detection resolution, single item, poor sensitivity of gas chromatography mass spectrometry, etc., and achieve the effect of high sensitivity

Pending Publication Date: 2020-06-19
厦门市三叶同创环保科技有限责任公司 +2
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  • Abstract
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  • Claims
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Problems solved by technology

Among them, the detection resolution of thin-layer chromatography and high-performance liquid chromatography is weak, and false positives often occur due to the many impurities in health food; the sensitivity of gas chromatography-mass spectrometry is poor; because liquid chromatography-tandem mass spectrometry has high sensitivity, The advantage of strong anti-interference ability is the most effective method to identify illegally added chemical drugs in health products
[0004...

Method used

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  • Simultaneous detection method for illegally added medicines in tranquilizing and allaying excitement health-care product
  • Simultaneous detection method for illegally added medicines in tranquilizing and allaying excitement health-care product
  • Simultaneous detection method for illegally added medicines in tranquilizing and allaying excitement health-care product

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Experimental program
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Embodiment

[0040] Prepare standard products: Accurately weigh 10 mg standard products (the standard products are respectively barbiturate, amobarbital, secobarbital, phenobarbital, diazepam, triazolam, lorazepam, clonazepam, nitrazepam, oxazepam, chlordiazepoxide, estazolam, alprazolam, chlorpromazine, and zaleplon) were placed in a 10mL volumetric flask, diluted with methanol to volume , to obtain each standard solution; then accurately pipette the above-mentioned each standard solution, add it to a 10mL volumetric flask, and dilute with methanol to form a mixed standard solution whose concentration of each standard is 100ng / mL;

[0041] Standard working curve configuration: Accurately draw 5 μL, 10 μL, 25 μL, 50 μL, and 100 μL of the above-mentioned mixed standard solutions into 50 mL centrifuge tubes, add methanol and vortex to mix the volume to 5 mL, ultrasonically extract for 20 minutes, centrifuge at 4000 r / min for 5 minutes, and take the supernatant Liquid 1mL, concentrated to nea...

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Abstract

The invention, which relates to the field of health care product detection, provides a simultaneous detection method for illegally added medicines in a tranquilizing and allaying excitement health-care product. Specifically, the method for simultaneous determination of illegally added drugs such as benzodiazepines, barbital and atypical benzodiazepines hypnotics in tranquilizing and allaying excitement health-care products by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS-MS) comprises the steps of extraction, purification, membrane filtration, tandem triple quadrupolemass spectrometry detection and establishment of a standard curve. The method is simple in steps, high in accuracy and good in reproducibility, can be used for qualitatively and quantitatively analyzing various illegally added medicines in the health care product at the same time, and has the advantage of rapid and high-throughput detection.

Description

technical field [0001] The invention belongs to the field of detection of health care products and provides a simultaneous detection method for illegally added drugs in health care products for tranquilizing and calming the nerves. Background technique [0002] Sleep is an important and necessary physiological need of the human body. Yet along with the quickening of social life rhythm, irregular, the increasing of pressure day by day, insomnia phenomenon becomes more and more serious. Modern medicine has carried out in-depth research on insomnia, and has gradually found a series of drugs for the treatment of insomnia, mainly containing barbiturates (first class), benzodiazepines (second class) and atypical benzodiazepines. These drugs have strong sedative and hypnotic effects, but long-term use can produce dependence and even toxic side effects. Therefore, some health care products with traditional Chinese medicines and proprietary Chinese medicines as the main ingredients...

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/047
Inventor 陈月龙付加亮洪家俊
Owner 厦门市三叶同创环保科技有限责任公司
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