An integrated medication reminder apparatus for providing audible reminder messages at predetermined times includes a
clock means for generating real time signals, a voice recorder / playback means for recording and playing voice reminder messages, a sleep-mode means for generating a communications
signal for communication with a secondary communications device, and an
acknowledgement means for generating
acknowledgement signals. A controller receives the real time signals and communications
signal, establishes communications with the secondary communications device, instructs the voice recorder / playback means to send and play the reminder messages at the secondary communications device at predetermined times, and initiates a phone call to a designated care-giver via a locally connected telephone, in the absence of an
acknowledgement signal after a voice reminder message has been played, and optionally, if removable a
pill box of a
pill dispenser coupled to the reminder apparatus is not removed and reinserted in a timely manner.