Murraya paniculata leaf and application of mono compound in preparation of sedative and hypnotic drugs

A technology of the leaves and extracts of Gurgifolium japonica, which is applied in the field of application of the extracts and monomeric compounds of Gulis japonica in the preparation of sedative and hypnotic drugs. Slow and other issues

Inactive Publication Date: 2012-10-03
长春瑞德医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although western medicine has the advantages of quick onset and strong effect, its toxic and side effects are generally relatively large, and it is easy to produce tolerance and dependence.
Although traditional Chinese medicine has the advantages of less toxic and side effects, and less tolerance and dependence, its disadvantages are slow onset and less effective than western medicine.

Method used

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  • Murraya paniculata leaf and application of mono compound in preparation of sedative and hypnotic drugs
  • Murraya paniculata leaf and application of mono compound in preparation of sedative and hypnotic drugs
  • Murraya paniculata leaf and application of mono compound in preparation of sedative and hypnotic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Extraction and separation of 5,7,3',4',5'-pentamethoxyflavone and 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone from the leaves of Gurifera , 5,7,3',4'-Tetramethoxyflavone

[0052] (1) Grind 1Kg of dried Gilija leaves, add water to decoct and extract 3 times, the amount of water added is 15 liters, 12 liters and 10 liters respectively, the decoction time is 2 hours, 1.5 hours and 1 hour respectively, and the three extracts are combined . The extract was adsorbed by an AB-8 macroporous adsorption resin column, washed with water, desorbed with 85% ethanol, and the ethanol was recovered to obtain 112 grams of jiulixiang leaf extract.

[0053] (2) Preliminary separation of flavonoids

[0054] Al 2 o 3 Column (2kg), eluting with ethyl acetate. The eluate was collected separately, detected by TLC, and the same components were combined to obtain J 1 、J 2 , and J 3 three parts.

[0055] (3) Separation and purification of monomeric compounds

[0056] Part J1 was ...

Embodiment 2

[0066] Example 2 Extraction and separation of 6, 7, 8, 3', 4'-pentamethoxy dihydroflavone, 2'-hydroxy-3,4,5,4',6'-pentamethoxyl Chichalcone

[0067] (1) Extraction

[0068] Take 5kg of dried coriander leaves and pulverize, and extract three times with 85% ethanol solution under reflux. The ethanol used for each time is 30L, 30L and 30L respectively, and the extraction time is 3h, 2h and 1h respectively. The three extracts were combined, concentrated to a certain extent, diluted with water to pass the AB-8 macroporous adsorption resin, eluted with 95% ethanol solution, and the solvent was recovered to obtain 500 g of extract.

[0069] (2) Separation and purification

[0070] The obtained 500g extract was subjected to silica gel column chromatography with petroleum ether:ethyl acetate-2:1 as the eluent, and six fractions A-F were obtained. Yellow crystals were precipitated in part B, filtered and recrystallized with ethyl acetate to obtain 2'-hydroxy-3,4,5,4',6'-pentamethoxyc...

Embodiment 3 9

[0076] Example 3 Preparation of Gulina officinalis extract A

[0077] Take 10 kilograms of dried coriander leaves, add water and reflux for extraction 5 times, the amount of water added is 14, 12, 10, 8, and 6 times, respectively, and the reflux time is 120, 90, 60, 60, and 45 minutes, respectively, filter, and combine the extracts , the solvent was recovered under reduced pressure, and dried to obtain the extract A of Fructus Fructus. Detected by HPLC, it contains 5,7,3',4',5'-pentamethoxyflavone, 6,7,8,3',4'-pentamethoxydihydroflavone, 5-hydroxy-6 , 7,8,3',4'-pentamethoxyflavone, 2'-hydroxy-3,4,5,4',6'-pentamethoxychalcone and 5,7,3',4 '-Tetramethoxyflavone.

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Abstract

The invention relates to the field of medicine and discloses a Murraya paniculata leaf, a Murraya paniculata leaf extractive and new biological activity of part of a flavonoid mono compound extracted from Murraya paniculata leaves, namely discloses a Murraya paniculata leaf, a Murraya paniculata leaf extractive and the use of part of a flavonoid mono compound extracted from Murraya paniculata leaves in preparation of sedative and hypnotic drugs, anxiolytic drugs, anticonvulsive drugs or antimanic drugs, in particular to the use in preparation of sedative and hypnotic drugs.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the novel biological activity of flavonoid monomer compounds in Fructus Fructus Use in the preparation of sedative-hypnotic drugs, anti-anxiety drugs, anti-epileptic drugs, anticonvulsants or anti-manic drugs, especially in the preparation of sedative-hypnotic drugs. Background technique [0002] Murrayapaniculata (L.) Jack mainly contains flavonoids, coumarins and alkaloids. The flavonoids reported in the literature so far are 3,5,6,7,8,3',4',5'-octamethoxyflavonoids, 3,5,6,7,3 ',4',5'-heptamethoxyflavone (Jiangsu New Medical College, Dictionary of Traditional Chinese Medicine, Volume 1, Shanghai People's Publishing House, 1977, 44-45); 5, 7, 8, 3', 4', 5' - Hexamethoxyflavone, 3,5,7,8,3',4',5'-heptamethoxyflavone (Acta Botany 1984, 26(2), 184-186); 5,7,3', 4',5'-pentamethoxyflavonoid (Acta Chem. 1984, 42:1308-1311); 5-hydroxy-6,7,8,3',4',5'-hexamethoxyflavonoid, 5,3 '-Dihydr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/12A61K36/75A61P25/20A61P25/22A61P25/08A61P25/18
Inventor 金永日睢大筼李绪文于晓风桂明玉
Owner 长春瑞德医药科技有限公司
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