Application of genistein and derivatives thereof in preparing hypnotic drugs

Abstract

The invention belongs to the field of compound drugs, relating to a new medicinal application of a compound genistein and derivatives thereof, in particular to the application of the genistein and the derivatives thereof in preparing hypnotic drugs and health products. The results of animal experiments for the genistein and the derivatives thereof show that the genistein and the derivatives thereof can cure insomnia by increasing non-rapid eyes movement sleeping time with an increase of about 80% in NREM sleep time within 6 hours after the animals being dosed. Especially, the NREM sleep time within 6 hours after the animals being dosed can be dosage-dependently increased. The genistein and the derivatives thereof have hypnotic activity and sleep quality improving effect, and can be used for preparing hypnotic drugs promoting sleep and drugs or health products improving sleep quality, especially suitable for treatment of sleep disorder in perimenopausal women.

Description

technical field [0001] The invention belongs to the field of compound drugs, and relates to the new medicinal application of compound genistein and its derivatives, in particular to the application of genistein and its derivatives in the preparation of hypnotic drugs. Background technique [0002] Studies have reported that one-third of life is spent in sleep, and sleep is as important as water, air, and food. With the acceleration of industrialization, the intensification of work pressure and social competition, night life and bad living habits, population aging and other reasons, one-third of the world's people have sleep problems, and 5% of them completely rely on drugs to maintain sleep . According to the 2006 survey data in my country, 57% of the people in Beijing, Shanghai and other six major cities have been troubled by insomnia in the past year. Sleep disorders are the cause of many diseases, and a considerable part of the population is in a "sub-healthy" state. A...

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Problems solved by technology

[0006] Pharmacological studies of genistein have shown that it is less addictive and dependent, and has preventive effects on breast cancer, prostate cancer, menopausal syndrome, cardiovascular disease and osteoporosis. and its derivatives are reported to promote sleep

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