8 results about "Pharmaceutical solvent" patented technology

The invention discloses a drug inspection reagent mixing device, and relates to the technical field of reagent mixing, the drug inspection reagent mixing device comprises a bottom plate and a U-shaped support plate arranged on the bottom plate, the U-shaped support plate is provided with at least two groups of transparent test tubes, the outer sides of the transparent test tubes are provided with output holes, and the U-shaped support plate is provided with a moving plate and a threaded adjusting rod; a blocking column and a blocking plate are fixedly connected to the upper portion of the moving plate, the blocking plate can be driven to move by pressing the moving plate or rotating the threaded adjusting rod so as to adjust the output quantity of the output hole, and a mixing container is arranged below the U-shaped supporting plate; the rotating rod is connected with the mixing container through the first pulling rope, the rotating rod is driven to control the rotating angle and speed, the shaking amplitude of the mixing container can be adjusted and controlled through the first pulling rope, the mixing container can adapt to the characteristics of the drug inspection reagent of an emulsion type solvent and a suspension type drug solvent, emulsion droplets are evenly dispersed on the premise that the membrane structure is not damaged, and the stability of the mixing container is improved. The emulsion stability is maintained.

The application discloses an albumin-nanoprotease drug delivery system, a preparation method thereof and application of the albumin-nanoprotease drug delivery system in preparation of a medicine for treating atherosclerotic plaques. The albumin-nanoprotease drug delivery system comprises drug-loaded nanoproteases and albumin coated on surfaces of the drug-loaded nanoproteases. The preparation method comprises the following steps: adding precursors, drugs, solvents and organic ligands into a reaction kettle, reacting at 80-200 DEG C, taking out solid products, drying the solid products to obtain drug-loaded nanoproteases, wherein the precursors contain two elements selected from Fe, Cu, Co, Ni, V, Mg, Mn, Zn, Ce and Se; and coating albumin on surfaces of the drug-loaded nanoproteases to obtain the albumin-nanoprotease drug delivery system. The albumin is coated on the drug-loaded nanoproteases for the first time, targets atherosclerotic plaques, relies on a targeted accumulation effect of the albumin on the atherosclerotic plaques, and synergistically improves a drug bioavailability by virtue of antioxidant and anti-inflammatory effects of the nanoproteases, so that the drug efficacy is increased and side effects are reduced.

The application discloses a kind of fat-soluble drug oral lyophilized composition and preparation method thereof, the fat-soluble drug oral lyophilized composition includes fat-soluble drug, solvent, suspending agent, binder and matrix agent, and the mass ratio of solvent and suspending agent is 3-10:1.Under the premise of not adding surfactant, the fat-soluble drug is uniformly dispersed in preparation system by adjusting the ratio of oil phase solvent and suspending agent, which reduces the adverse effects of low solubility, poor dispersibility and poor stability of fat-soluble drug (such as vitamin K1 and K2) on pharmaceutical, and eliminates the influence of surfactant.In addition, the tablet of the application has uniform color, smooth and flat surface, neat edge, no melting and collapse, which improves the quality of tablet.

The invention belongs to the technical field of drug solvent residue detection, and particularly relates to a method for detecting a residual solvent 3, 5-dimethylpiperidine in a tilmicosin bulk drug. The method comprises the following steps: preparing a reference solution and a test solution, determining the content of the residual solvent 3, 5-dimethylpiperidine in the tilmicosin bulk drug by adopting gas chromatography-headspace sampling, and calculating the residual quantity according to an external standard method. The detection method is simple, accurate, good in repeatability and high in sensitivity; the method is suitable for daily detection of 3, 5-dimethylpiperidine serving as a tilmicosin raw material medicine, and the medication safety of tilmicosin is ensured by controlling the residual solvent amount in veterinary medicine tilmicosin, so that infectious diseases of animals such as pigs and chickens can be effectively and safely prevented and treated. According to the method, the blank of the method for detecting the residual solvent 3, 5-dimethylpiperidine in the tilmicosin is filled, the quality of the raw material medicine is effectively improved, and the clinical medication risk is reduced.

The invention relates to a composition for preventing and treating sanitary pests, in particular to a meperfluthrin-containing composition for preventing and treating sanitary pests and application. The composition is prepared from the following components in percentage by weight: 0.1 to 50 percent of meperfluthrin A, 20 to 99.8 percent of C8-C19 lower alkane solvent B and 0.1 to 79.9 percent of solvent C, according to the meperfluthrin composition disclosed by the invention, a non-raw-drug solvent with permeability and natural plant essential oil and the like are added into a meperfluthrin parent drug, so that the drug effect of the meperfluthrin parent drug in actual use is increased, the activity of meperfluthrin is improved, and the quality of the meperfluthrin parent drug is improved.

The utility model relates to the technical field of medicine solvent automatic labeling, and particularly discloses a feeding device of a solvent marking and labeling machine, which comprises a rack, a first conveying line, a visual identification module, a guide module and a control module, the visual identification module is arranged at the upstream end of the first conveying line and is used for identifying a first label on a solvent, and the guide module is arranged corresponding to the first conveying line and is configured to position the solvent and guide the solvent to move along the first conveying line; according to the scheme, after a worker places the solvent on the first conveying line, the visual identification module at the upstream end of the first conveying line can identify the first label on the solvent, and the first label can be an original factory identification label, can comprise basic information such as names, specifications, batch numbers and validity periods of medicines in the solvent, and is original data which cannot be tampered; and after the comparison with the database information is passed, the control module can control the first conveying line to act and convey the solvent to a subsequent labeling station.

The invention relates to the technical field of pharmaceutical preparations for treating ischemic myocardial injury, in particular to a tanshinone IIA oral carrier-free nano preparation and a preparation method thereof.An anti-solvent method is adopted, firstly, a compound solvent is prepared from acetic acid, acetic anhydride and ethyl alcohol, tanshinone IIA is dissolved to obtain a pharmaceutical solvent phase, a stabilizer is dissolved in deionized water to obtain an anti-solvent phase, and then the anti-solvent phase is added into the anti-solvent phase to prepare the tanshinone IIA oral carrier-free nano preparation. And mixing the two components at a proper temperature, precipitating, adding a freeze-drying protective additive, and freeze-drying to obtain the preparation. SEM (scanning electron microscope), DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and FT-IR (Fourier transform infrared spectroscopy) characterization are combined with in-vitro dissolution and H9c2 myocardial cell experiment verification; the tanshinone IIA oral carrier-free nano preparation has the advantages that the particle size is obviously reduced, the distribution is uniform, the crystallinity is reduced, the molecular structure is not changed, the dissolution rate is obviously improved, the activity of myocardial cells damaged by H2O2 can be obviously improved, the nano preparation is superior to a raw material medicine, the nano preparation has the advantages of high drug loading capacity and no toxicity, and the nano preparation can efficiently resist ischemic myocardial injury.

The invention discloses a medicinal solvent capable of inhibiting irritation of an external medicament, which is an external medicament solvent, and adopts an alcohol solvent which is easy to dissolve in water, not easy to volatilize and non-toxic to inhibit the irritation of the external medicament to the skin and inhibit the volatilization of volatile effective components in the external medicament, so that the irritation of the external medicament to the skin is inhibited. Therefore, absorption of skin to the medicament is promoted, no irritation is caused, and administration time is prolonged; the alcohol solvent can be ethylene triol, glycerol, ethylene glycol, propylene glycol, butanediol or diethylene glycol; different effective component extraction modes are implemented according to different temperature resistance of the effective components of the external medicament, including soaking extraction at the temperature of 0-70 DEG C, high-temperature extraction at the temperature of 100-170 DEG C and extraction of the external medicament insoluble in an alcohol solvent by means of a third solvent, so that the external medicament can carry sufficient effective components.