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Contraceptive and preparation method thereof

A contraceptive drug and drug technology, which is applied in the field of drugs, can solve the problems of high failure rate, achieve the effects of improving reliability, ensuring contraceptive effect, and reducing toxic and side effects

Inactive Publication Date: 2016-07-27
郭曙平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with other contraceptive methods, its advantage is that some spermicidal drugs can also prevent the transmission of sexually transmitted diseases while contraceptive; the disadvantage is that the failure rate of external contraceptives is the highest among all contraceptive methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take 1.5g of levonorgestrel, dissolve it in 90g of glycerol; take another 50g of nonoxynol, dissolve it in about 860g of purified water, mix the two liquids, add 0.5g of carbomer, and shear and mix evenly. Or take 1.5g of levonorgestrel, dissolve it in 50g of liquid paraffin; take another 50g of nonoxynol, 0.5g of carbomer, and 605g of span, dissolve it in about 900g of purified water, mix the two liquids, and shear emulsify uniform. Or take 1.5g of levonorgestrel, dissolve it in polyethylene glycol 400-800g; take another 50g of nonoxynol, dissolve it in melted polyethylene glycol 4000-1200g, mix the two liquids, and inject them into suppository molds. From this it is possible to obtain levonorgestrel nonoxynol gel, emulsion or suppository.

Embodiment 2

[0039]Take 1.5g of levonorgestrel, dissolve it in 90g of glycerol; take another 10g of benzalkonium chloride, dissolve it in about 900g of purified water, mix the two liquids, add 0.5g of carbomer, and shear and mix evenly. Or take 1.5g of levonorgestrel, dissolve it in 50g of liquid paraffin; take another 10g of benzalkonium chloride, 0.5g of carbomer, and 605g of span, dissolve it in about 935g of purified water, mix the two liquids, and shear and emulsify evenly . Or take 1.5g of levonorgestrel and dissolve it in polyethylene glycol 400-800g; take another 10g of benzalkonium chloride and dissolve it in melted polyethylene glycol 4000-1200g, mix the two liquids, and inject them into suppository molds. From this it is possible to obtain levonorgestrel-benzalkonium chloride gel, cream or suppository.

Embodiment 3

[0041] Take 1.5g of levonorgestrel, dissolve it in 90g of glycerol; take another 5g of chlorhexidine, dissolve it in about 905g of purified water, mix the two liquids, add 0.5g of carbomer, and shear and mix evenly. Or take 1.5g of levonorgestrel, dissolve it in 50g of liquid paraffin; take another 5g of chlorhexidine, 0.5g of carbomer, and 605g of span, dissolve it in about 940g of purified water, mix the two liquids, and shear and emulsify evenly . Alternatively, take 1.5 g of levonorgestrel and dissolve it in 400-800 g of polyethylene glycol; take another 5 g of chlorhexidine, dissolve it in molten polyethylene glycol 4000-1200 g, mix the two liquids, and inject them into a suppository mold. From this it is possible to obtain levonorgestrel-chlorhexidine gel, cream or suppository.

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PUM

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Abstract

The invention relates to a contraceptive and a preparation method thereof. The present invention provides a hormonal contraceptive, and a chemical contraception prescription. An oral contraceptive hormone is dissolved or dispersed in an organic pharmaceutical solvent to prepared a stock solution; an external contraceptive is dissolved in purified water or a pharmaceutically acceptable solid carrier to dissolve the drug into a preparation; and the stock solution containing the oral contraceptive and prepared mixture containing external contraceptive are mixed. The present invention overcomes the respective defects of oral contraceptive and external contraceptive. The contraceptive takes the respective advantages of the oral and external contraceptives, and uses good drug absorption of the female vagina, especially sensitivity and dependence on hormone drugs to combine the characteristics of oral contraceptive and external contraceptive. The contraceptive creatively combines the two to avoid drug stimulation on the gastrointestinal tract, avoid the drug inactivation caused by liver first-pass metabolism, also reduce the dose, and form a novel pharmaceutical prescription.

Description

technical field [0001] The invention relates to a medicine, in particular to a contraceptive medicine and a preparation method thereof. Background technique [0002] Contraception, as the name suggests, is to make women achieve the goal of not getting pregnant through unnatural means. [0003] Three conditions are usually necessary for a woman to conceive: [0004] 1. The male can produce a sufficient number of sound and motile sperm, and can enter the female vagina. [0005] 2. After the sperm enters the vagina, it must be able to maintain its mobility and pass through the cervix and uterine cavity to reach the fallopian tube and combine with the egg to form a fertilized egg. [0006] 3. The fertilized egg must develop into an embryo in time and reach the uterine cavity, and the environment of the uterine cavity is suitable for the growth of the embryo. [0007] The existing contraceptive methods include tubal ligation, intrauterine devices, condoms, and birth control pi...

Claims

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Application Information

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IPC IPC(8): A61K31/567A61K31/57A61K9/02A61K9/06A61P15/18A61P31/02A61K31/085A61K31/155A61K31/14
Inventor 陈妍施翼麟郭曙平
Owner 郭曙平
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