Qingkailing prepn for great transfusion and its prepn process

A technology for large infusions and preparations, applied in anti-inflammatory agents, pharmaceutical formulations, drug delivery and other directions, can solve problems such as the problem of clarity of small injections of traditional Chinese medicine, easy deterioration of Qingkailing injection, and increased workload of medical staff, etc. To achieve the effect of eliminating cross-contamination, good clarity, and improving the quality of medication

Inactive Publication Date: 2007-08-22
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Qingkailing injection also has the following deficiencies in clinical application: 1. The pharmaceutical composition of Qingkailing injection contains chlorogenic acid, which is unstable under visible light, and the photosensitive surface of the small injection is highly dispersed due to the high degree of dispersion of the medicine in the small injection. increase, thus making Qingkailing injection perishable and poor in stability
2. The clarity of small injections of traditional Chinese medicine is prone to problems, and the product quality is difficult to control
3. Since Qingkailing preparations often need to be used in large doses in clinical practice, taking Qingkailing small injections to extract glucose or sodium chloride to obtain Qingkailing large infusions, the intermediate links are likely to cause cross-infection, and the safety of medication is difficult protection, but also increase the workload of medical staff

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1: Preparation of Qingkailing Glucose Infusion Preparation

[0011] (1) Add 23g of honeysuckle, 9g of gardenia, and 75g of Radix Isatidis, and decoct them twice with water. ~ 90 minutes, gardenia decoction 20 ~ 90 minutes each time. Then extract the decoction of honeysuckle, gardenia, and Radix Isatidis respectively, and each extraction time is 1 hour, respectively combine two extracts of each medicinal material, filter, and concentrate the filtrate. The volume of the concentrated filtrate is the same as that of each medicinal material same size. Then add ethanol to 60% alcohol content, refrigerate for 24 hours, filter again, recover ethanol, and obtain honeysuckle extract, gardenia extract and Radix isatidis extract respectively.

[0012] (2) Hydrolyze 9 g of buffalo horn and 18 g of mother-of-pearl with barium hydroxide solution and concentrated sulfuric acid solution for 8 hours, then filter, combine the filtrates, adjust the pH value of the filtrate to 3.5...

Embodiment 2

[0016] Example 2: Preparation of Qingkailing Glucose Infusion Preparation

[0017] The weight ratio of the raw material Chinese medicinal materials or their extracts used in this example is as follows: 38g of honeysuckle, 16g of Gardenia, 125g of Radix Radix, 16g of buffalo horn, 32g of mother of pearl, 3.2g of baicalin, 2.0g of cholic acid, hyodeoxycholic acid 2.4g.

[0018] Steps (1) to (4) of the preparation method of this embodiment are the same as in Example 1, and step (5) is as follows:

[0019] Mix the mixed solution prepared in the above step (4) with the silvery yellow solution, add glucose solution for injection with a concentration of 5-10% to 1L, then heat and stir with 0.1-0.2% activated carbon for 30 minutes, refrigerate and filter, and filter with pore size Filter again with a nanofiltration membrane of 0.22 μm, fill the obtained light yellow clear liquid into a 100mL or 250mL or 500mL infusion bottle, sterilize it in steam at 100°C for 30 minutes, and obtain ...

Embodiment 3

[0020] Example 3: Preparation of Qingkailing Sodium Chloride Infusion Preparation

[0021] The weight ratio of the raw material Chinese medicinal materials or their extracts used in this example is as follows: 30g of honeysuckle, 13g of gardenia, 105g of Radix Isatidis, 13g of buffalo horn, 25g of mother of pearl, 2.5g of baicalin, 1.6g of cholic acid, hyodeoxycholic acid 1.9g.

[0022] Steps (1) to (4) of the preparation method of this embodiment are the same as in Example 1, and step (5) is as follows:

[0023] Mix the mixed solution prepared in the above step (4) with the silvery yellow liquid, add 0.9% sodium chloride solution for injection to 10L, heat and stir with 0.1-0.2% activated carbon for 30 minutes, refrigerate and filter, and filter with pore size Filter again with a nanofiltration membrane of 0.22 μm, fill the obtained light yellow clear liquid into a 100mL or 250mL or 500mL infusion bottle, sterilize it in steam at 100°C for 30 minutes, and obtain Qingkailing ...

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PUM

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Abstract

The Qingkailing preparation for great transfusion is prepared with cholic acid 1.2-2.0 weight portions, hyodeoxycholic acid 1.4-2.4 weight portions, buffalo horn 9-16 weight portions, baicalin 1.8-3.2 weight portions, nacre 18-32 weight portions, cape jasmine 9-16 weight portions, isatis root 75-125 weight portions, and honeysuckle 23-38 weight portions. It is prepared through extraction, hydrolysis, mixing, filtering, active carbon treatment, sterilizing and other steps. The Qingkailing preparation for great transfusion has high clarity, high stability, high safety and other advantages, and is suitable for medical care personnel to use.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a Qingkailingda transfusion preparation and a preparation method thereof. Background technique [0002] The series of Qingkailing preparations developed from the ancient prescription Angong Niuhuang Pills by dismantling the formula and reducing the flavor, currently have Qingkailing injection, Qingkailing powder injection, Qingkailing oral liquid, Qingkailing granules, etc. Dosage forms, Qingkailing injection in small injections is the most commonly used clinically. Qingkailing Injection has the effects of clearing away heat and detoxification, calming the nerves, and treating acute and chronic hepatitis, severe cold, high fever and other diseases. In 1995, it was listed as an essential drug by the Ministry of Health of the People's Republic of China, and was designated as one of the twenty first-aid clinical drugs at the same time. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/08A61P29/00A61P1/16A61K35/32A61K35/56A61K31/7048A61K31/575A61K35/618
Inventor 罗国安王义明刘清飞梁琼麟汪红英
Owner TSINGHUA UNIV
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